5e046ab2d1d8ec59a16ab5846470bc68 309298.pdf deabd7b70139943754612d5150dcc190cf8c8d75 309298.pdf 4ea1c9f29da6f061f9bf462ade0d480e5e6bf0002690d9470a7a3b2b9cb586d3 309298.pdf Title: Burden of Mitral Regurgitation in Spain from 2016–2021: An Analysis by Aetiology and Sex Subject: Objectives: Mitral regurgitation (MR) is the second most common valve disease in Europe, and differences between men and women have been described in relation to aetiology or management, which might impact the decision for intervention and patients’ clinical and economic outcomes. Thus, the objective was to analyse the burden of MR in Spain by aetiology and sex, and the management of all patients suffering from MR being admitted to hospital between 2016–2021. Methods: An analysis was carried out with the Ministry of Health’s database, including all patients in public and subsidised hospitals and defining two groups, general MR and those patients undergoing Transcatheter Edge-to-Edge repair (TEER), using a descriptive analysis of patients’ characteristics, use of resources, and outcomes; standardised rates were calculated and observed outcomes were described. Results: Hospital admissions increased from 2016 (n = 32,806) to 2021 (total n = 61,036). In general, the women were older and presented more complications. The majority of patients suffered from degenerative MR (DMR) (n = 183,005, 59.55%), and 61.56% were women, contrary to functional MR (FMR) (n = 124,278), which consisted of 62.15% males. In total, 1,689 TEERs were performed, 23.33% of them in urgent admissions, and mostly in men (65.66%). All groups showed higher rates of intervention for males. Regarding costs, women presented lower mean costs in the general MR groups but those undergoing TEER presented, in all cases, costs higher than men. Conclusions: MR entails a significant burden for patients and the Spanish healthcare system, increasing over the period of study. Differences in aetiologies by sex have been found in patients’ characteristics as well as outcomes. Further studies are needed to optimise patients’ management and their outcomes in relation to sex and aetiology. Keywords: mitral regurgitation; burden of illness; TEER; sex Author: José Luis Zamorano, Mercedes Álvarez-Bartolomé, Dabit Arzamendi, Manuel Carnero-Alcázar, Ignacio Cruz-González, Chi-Hion Pedro Li, Ana Pardo-Sanz, Óscar Martínez-Pérez, Mónica Cerezales, Jesús Cuervo, Matteo Vernia, Paloma González and Belén Martí-Sánchez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Oct 24 11:29:41 2024 CEST ModDate: Thu Oct 24 11:46:53 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1968849 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QMCQLP+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 IHOBIR+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 DPIMVO+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 WPLPHH+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 KZFVFW+VnURWPalladioL Type 1 Custom yes yes yes 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 CCGMBL+CMSY10 Type 1 Builtin yes yes yes 71 0 MXLXCG+wasy5 Type 1 Builtin yes yes yes 97 0 ACLJIB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 105 0 ACLJJD+PalatinoLinotype TrueType WinAnsi yes yes no 108 0 ACLJJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 111 0 ACLJIB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 122 0 ACLJJD+PalatinoLinotype TrueType WinAnsi yes yes no 125 0 ACLJJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 128 0 ACLJIB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 136 0 ACLJJD+PalatinoLinotype TrueType WinAnsi yes yes no 139 0 ACLJJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 142 0 ACLJIB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 154 0 ACLJJD+PalatinoLinotype TrueType WinAnsi yes yes no 157 0 ACLJJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 160 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-25 02:41:42 CET RepresentationInformation: 309298.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-24 12:53:31 CET Size: 1968849 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 328 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Data Source Destination: subsection.2.1 Item: Title: Statistical Approach Destination: subsection.2.2 Item: Title: Results Destination: section.3 Children: Item: Title: Patients’ Hospitalisations with an MR Diagnosis Destination: subsection.3.1 Children: Item: Title: DMR Destination: subsubsection.3.1.1 Item: Title: FMR Destination: subsubsection.3.1.2 Item: Title: TEER Procedures Destination: subsection.3.2 Item: Title: Rates of MR and TEER Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Burden of Mitral Regurgitation in Spain from 2016 2021: An Analysis by Aetiology and Sex Author: José Luis Zamorano, Mercedes Álvarez-Bartolomé, Dabit Arzamendi, Manuel Carnero-Alcázar, Ignacio Cruz-González, Chi-Hion Pedro Li, Ana Pardo-Sanz, Óscar Martínez-Pérez, Mónica Cerezales, Jesús Cuervo, Matteo Vernia, Paloma González and Belén Martí-Sánchez Subject: Objectives: Mitral regurgitation (MR) is the second most common valve disease in Europe, and differences between men and women have been described in relation to aetiology or management, which might impact the decision for intervention and patients’ clinical and economic outcomes. Thus, the objective was to analyse the burden of MR in Spain by aetiology and sex, and the management of all patients suffering from MR being admitted to hospital between 2016 2021. Methods: An analysis was carried out with the Ministry of Health’s database, including all patients in public and subsidised hospitals and defining two groups, general MR and those patients undergoing Transcatheter Edge-to-Edge repair (TEER), using a descriptive analysis of patients’ characteristics, use of resources, and outcomes; standardised rates were calculated and observed outcomes were described. Results: Hospital admissions increased from 2016 (n = 32,806) to 2021 (total n = 61,036). In general, the women were older and presented more complications. The majority of patients suffered from degenerative MR (DMR) (n = 183,005, 59.55%), and 61.56% were women, contrary to functional MR (FMR) (n = 124,278), which consisted of 62.15% males. In total, 1,689 TEERs were performed, 23.33% of them in urgent admissions, and mostly in men (65.66%). All groups showed higher rates of intervention for males. Regarding costs, women presented lower mean costs in the general MR groups but those undergoing TEER presented, in all cases, costs higher than men. Conclusions: MR entails a significant burden for patients and the Spanish healthcare system, increasing over the period of study. Differences in aetiologies by sex have been found in patients’ characteristics as well as outcomes. Further studies are needed to optimise patients’ management and their outcomes in relation to sex and aetiology. 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