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Keywords: acute myeloid leukemia; eculizumab; hemolytic uremic syndrome Author: Jonas El Bachouti, Anna Domínguez-Guasch, Yolanda Arce, Guadalupe Oñate, Helena Marco, Montserrat Diaz, Lluís Guirado, Roser Torra and Xoana Barros Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Oct 30 08:39:41 2024 CET ModDate: Wed Oct 30 08:48:48 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1079013 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 KSVXGV+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 HJEFWE+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 HLBYPC+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 BAMNYG+VnURWPalladioL Type 1 Custom yes yes yes 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 IXLVLQ+CMSY10 Type 1 Builtin yes yes yes 68 0 OEAFAG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 83 0 OEAFAI+PalatinoLinotype TrueType WinAnsi yes yes no 86 0 OEAFAK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 89 0 OEAFHI+PalatinoLinotype TrueType MacRoman yes yes no 92 0 OEAGEE+Arial CID TrueType Identity-H yes yes yes 95 0 OEAFAG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 OEAFAI+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 OEAFAK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 OEAFHI+PalatinoLinotype TrueType MacRoman yes yes no 129 0 OEAHMM+Calibri CID TrueType Identity-H yes yes yes 132 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes yes 149 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-25 02:41:40 CET RepresentationInformation: 309299.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-24 12:53:40 CET Size: 1079013 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 223 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Clinical Case Destination: section.2 Item: Title: Discussion Destination: section.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Acute Myeloid Leukemia as a Trigger for Hemolytic Uremic Syndrome Author: Jonas El Bachouti, Anna Domínguez-Guasch, Yolanda Arce, Guadalupe Oñate, Helena Marco, Montserrat Diaz, Lluís Guirado, Roser Torra and Xoana Barros Subject: Acute myeloid leukemia (AML) has not been identified as a cause of secondary hemolytic uremic syndrome (HUS). This case report describes a woman who developed severe HUS at the time of AML diagnosis and responded favorably to initial treatment with eculizumab, which stabilized her condition and allowed for treatment of the AML. After one year, with stable renal function and genetic studies reported as normal, eculizumab was successfully discontinued. The prompt use of eculizumab was critical to the patient’s survival and improvement in renal function, highlighting the efficacy of early eculizumab treatment in secondary HUS. 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