f7e9a3057cfb9e45735ea4efef8df169  309316.pdf
23580c843052a0f7c3b53d2ac74adecb8ff19dcd  309316.pdf
d34f6d75aa6aac66e9c502b3c573d80a1ebe3b068b6b5b2700317c76447cd059  309316.pdf

Title:           Eftilagimod Alpha (a Soluble LAG-3 Protein) Combined With Pembrolizumab in Second-Line Metastatic NSCLC Refractory to Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1-Based Therapy: Final Results from a Phase 2 Study
Subject:         JTO Clinical and Research Reports, 5 (2024) 100725. doi:10.1016/j.jtocrr.2024.100725
Author:          Matthew G. Krebs MD
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Sat Oct 26 00:07:14 2024 CEST
ModDate:         Sat Oct 26 16:11:54 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       584.957 x 782.986 pts
Page rot:        0
File size:       762442 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IBALBD+AdvTTda6f6cb8.B+fb            Type 1C           Custom           yes yes yes    782  0
IBALBE+AdvTT43930a72.BI              Type 1C           WinAnsi          yes yes no     777  0
IBALBF+AdvPSSym                      Type 1C           Custom           yes yes yes    781  0
IBAKNJ+AdvTTc9c3bd71                 Type 1C           WinAnsi          yes yes no     744  0
IBAKPJ+AdvTTc9c3bd71+20              Type 1C           WinAnsi          yes yes no     749  0
IBAKPK+AdvTT7f5838b0.I               Type 1C           WinAnsi          yes yes no     766  0
IBALAL+AdvTT0eeac7f7.B               Type 1C           WinAnsi          yes yes no     769  0
IBALAM+AdvTT08640291                 Type 1C           WinAnsi          yes yes no     752  0
IBALAN+AdvP4C4E74                    Type 1C           Custom           yes yes yes    758  0
IBALAO+AdvTT08640291+20              Type 1C           WinAnsi          yes yes no     762  0
IBALAP+AdvTT08640291+fb              Type 1C           Custom           yes yes yes    759  0
IBALBA+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     761  0
IBALBB+AdvTTda6f6cb8.B               Type 1C           WinAnsi          yes yes no     783  0
IBALBC+AdvTTda6f6cb8.B+20            Type 1C           WinAnsi          yes yes no     785  0
IBALDF+AdvTT9cc80a3e.I               Type 1C           WinAnsi          yes yes no     450  0
IBALEG+AdvOTb0c9bf5d                 Type 1C           WinAnsi          yes yes no     444  0
IBALFG+AdvTT7f5838b0.I+fb            Type 1C           Custom           yes yes yes    456  0
IBALGH+AdvTTc9c3bd71+fb              Type 1C           Custom           yes yes yes    459  0
IBAOJF+AdvP4C4E59                    Type 1C           Custom           yes yes no     471  0
IBAOKF+AdvMathPi6                    Type 1C           WinAnsi          yes yes no     474  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-04-04 02:43:26 CEST
 RepresentationInformation: 309316.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-04-03 12:43:21 CEST
  Size: 762442
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'cor1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-122
   Offset: 731561
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found
   ID: PDF-HUL-122
   Offset: 731561
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 859
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Eftilagimod Alpha (a Soluble LAG-3 Protein) Combined With Pembrolizumab in Second-Line Metastatic NSCLC Refractory to Anti– ...
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Materials and Methods
        Destination: flink2
        Children: 
         Item: 
          Title: Patients
          Destination: slink1
         Item: 
          Title: Treatment
          Destination: slink2
         Item: 
          Title: Measures
          Destination: slink3
         Item: 
          Title: Outcomes
          Destination: slink4
         Item: 
          Title: Statistical Analysis
          Destination: slink5
         Item: 
          Title: Patient and Public Involvement
          Destination: slink6
       Item: 
        Title: Results
        Destination: flink3
        Children: 
         Item: 
          Title: Patients
          Destination: slink7
         Item: 
          Title: Efficacy
          Destination: slink8
          Children: 
           Item: 
            Title: Exposure
            Destination: thirlink1
           Item: 
            Title: Primary and Secondary Analyses
            Destination: thirlink2
           Item: 
            Title: Exploratory Analyses
            Destination: thirlink3
         Item: 
          Title: Safety
          Destination: slink9
       Item: 
        Title: Discussion
        Destination: flink4
       Item: 
        Title: Conclusion
        Destination: flink5
       Item: 
        Title: CRediT Authorship Contribution Statement
        Destination: flink6
       Item: 
        Title: Ethics Approval and Consent to Participate
        Destination: flink7
       Item: 
        Title: Ethics Approval and Consent to Participate
        Destination: flink8
       Item: 
        Title: Availability of Data and Material
        Destination: flink9
       Item: 
        Title: Supplementary Data
        Destination: flink11
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Eftilagimod Alpha (a Soluble LAG-3 Protein) Combined With Pembrolizumab in Second-Line Metastatic NSCLC Refractory to Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1-Based Therapy: Final Results from a Phase 2 Study
    Author: Matthew G. Krebs MD
    Subject: JTO Clinical and Research Reports, 5 (2024) 100725. doi:10.1016/j.jtocrr.2024.100725
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Sat Oct 26 00:37:14 CEST 2024
    ModDate: Sat Oct 26 16:41:54 CEST 2024
   ID: 0x55045536079a874f4ab7b2966f5056c0, 0xb7af9b085b48ee4cba71be75b7a0e0fd
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2049
      ImageHeight: 561
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1659
      ImageHeight: 618
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1352
      ImageHeight: 852
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IBALAL+AdvTT0eeac7f7.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: IBALAL+AdvTT0eeac7f7.B
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -218, 958, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALDF+AdvTT9cc80a3e.I
      FontSubset: true
      FirstChar: 49
      LastChar: 121
      FontDescriptor: 
       FontName: IBALDF+AdvTT9cc80a3e.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBAKNJ+AdvTTc9c3bd71
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: IBAKNJ+AdvTTc9c3bd71
       Flags: Nonsymbolic
       FontBBox: -31, -218, 843, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALFG+AdvTT7f5838b0.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBALFG+AdvTT7f5838b0.I+fb
       Flags: Symbolic
       FontBBox: -41, -197, 1354, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBALBE+AdvTT43930a72.BI
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: IBALBE+AdvTT43930a72.BI
       Flags: Nonsymbolic
       FontBBox: -72, -218, 979, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALGH+AdvTTc9c3bd71+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IBALGH+AdvTTc9c3bd71+fb
       Flags: Symbolic
       FontBBox: 9, -197, 1302, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBALBF+AdvPSSym
      FontSubset: true
      FirstChar: 2
      LastChar: 170
      FontDescriptor: 
       FontName: IBALBF+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBAKPJ+AdvTTc9c3bd71+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IBAKPJ+AdvTTc9c3bd71+20
       Flags: Nonsymbolic
       FontBBox: 0, -239, 1072, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALBD+AdvTTda6f6cb8.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBALBD+AdvTTda6f6cb8.B+fb
       Flags: Symbolic
       FontBBox: 9, -197, 1385, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBALBB+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 40
      LastChar: 233
      FontDescriptor: 
       FontName: IBALBB+AdvTTda6f6cb8.B
       Flags: Nonsymbolic
       FontBBox: -72, -218, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALAM+AdvTT08640291
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: IBALAM+AdvTT08640291
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -208, 916, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALBC+AdvTTda6f6cb8.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IBALBC+AdvTTda6f6cb8.B+20
       Flags: Nonsymbolic
       FontBBox: 0, -239, 1125, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALAN+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 254
      FontDescriptor: 
       FontName: IBALAN+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBALAP+AdvTT08640291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: IBALAP+AdvTT08640291+fb
       Flags: Symbolic
       FontBBox: 30, 0, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBAOJF+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IBAOJF+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: IBALBA+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: IBALBA+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALAO+AdvTT08640291+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: IBALAO+AdvTT08640291+20
       Flags: Nonsymbolic
       FontBBox: -187, -197, 1208, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBAOKF+AdvMathPi6
      FontSubset: true
      FirstChar: 113
      LastChar: 113
      FontDescriptor: 
       FontName: IBAOKF+AdvMathPi6
       Flags: Nonsymbolic
       FontBBox: 0, -177, 989, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBALEG+AdvOTb0c9bf5d
      FontSubset: true
      FirstChar: 177
      LastChar: 177
      FontDescriptor: 
       FontName: IBALEG+AdvOTb0c9bf5d
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IBAKPK+AdvTT7f5838b0.I
      FontSubset: true
      FirstChar: 44
      LastChar: 243
      FontDescriptor: 
       FontName: IBAKPK+AdvTT7f5838b0.I
       Flags: Nonsymbolic
       FontBBox: -62, -218, 927, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jtocrr.2024.100725</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Eftilagimod Alpha (a Soluble LAG-3 Protein) Combined With Pembrolizumab in Second-Line Metastatic NSCLC Refractory to Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1-Based Therapy: Final Results from a Phase 2 Study</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Matthew G. Krebs MD</rdf:li>
               <rdf:li>Martin Forster MD PhD</rdf:li>
               <rdf:li>Margarita Majem MD PhD</rdf:li>
               <rdf:li>Julio Peguero MD</rdf:li>
               <rdf:li>Wade Iams MD</rdf:li>
               <rdf:li>Tim Clay MD</rdf:li>
               <rdf:li>Patricia Roxburgh MD PhD</rdf:li>
               <rdf:li>Bernard Doger MD PhD</rdf:li>
               <rdf:li>Pawan Bajaj MD</rdf:li>
               <rdf:li>Andres Barba MD</rdf:li>
               <rdf:li>Suvini Perera MS</rdf:li>
               <rdf:li>Christian Mueller MS</rdf:li>
               <rdf:li>Frédéric Triebel MD PhD</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Non–small cell lung cancer</rdf:li>
               <rdf:li>Anti-PD-(L)1 Refractory</rdf:li>
               <rdf:li>Eftilagimod alpha</rdf:li>
               <rdf:li>Immune checkpoint inhibitor</rdf:li>
               <rdf:li>Pembrolizumab</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">JTO Clinical and Research Reports, 5 (2024) 100725. doi:10.1016/j.jtocrr.2024.100725</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>JTO Clinical and Research Reports</prism:publicationName>
         <prism:copyright>© 2024 The Authors. Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer.</prism:copyright>
         <prism:issn>2666-3643</prism:issn>
         <prism:volume>5</prism:volume>
         <prism:number>11</prism:number>
         <prism:coverDisplayDate>November 2024</prism:coverDisplayDate>
         <prism:pageRange>100725</prism:pageRange>
         <prism:startingPage>100725</prism:startingPage>
         <prism:doi>10.1016/j.jtocrr.2024.100725</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jtocrr.2024.100725</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jtocrr.2024.100725</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0.1</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jtocrr.2024.100725</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2024-10-26T03:37:14+05:30</xap:CreateDate>
         <xap:ModifyDate>2024-10-26T19:41:54+05:30</xap:ModifyDate>
         <xap:MetadataDate>2024-10-26T19:41:54+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:tdm="http://www.w3.org/ns/tdmrep/">
         <tdm:reservation>1</tdm:reservation>
         <tdm:policy>https://www.elsevier.com/tdm/tdmrep-policy.json</tdm:policy>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:6d302481-0f75-4c43-880d-aeb366542b69</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:02b0799b-48f2-47f0-974a-1b879d044532</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 140, 557, 140, 559
      Annotation: 
       Subtype: Link
       Rect: 168, 561, 173, 572
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 252, 557, 252, 559
      Annotation: 
       Subtype: Link
       Rect: 307, 561, 312, 572
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 406, 557, 406, 559
      Annotation: 
       Subtype: Link
       Rect: 462, 561, 467, 572
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 116, 543, 116, 545
      Annotation: 
       Subtype: Link
       Rect: 144, 547, 149, 559
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 210, 543, 210, 545
      Annotation: 
       Subtype: Link
       Rect: 238, 547, 243, 559
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 294, 543, 294, 545
      Annotation: 
       Subtype: Link
       Rect: 321, 547, 324, 559
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 421, 543, 421, 545
      Annotation: 
       Subtype: Link
       Rect: 478, 547, 482, 559
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 120, 529, 120, 532
      Annotation: 
       Subtype: Link
       Rect: 174, 533, 179, 545
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 247, 529, 247, 532
      Annotation: 
       Subtype: Link
       Rect: 275, 533, 277, 545
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 350, 529, 350, 532
      Annotation: 
       Subtype: Link
       Rect: 378, 533, 383, 545
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 455, 529, 455, 532
      Annotation: 
       Subtype: Link
       Rect: 481, 533, 485, 545
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 135, 515, 135, 518
      Annotation: 
       Subtype: Link
       Rect: 160, 519, 163, 531
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 252, 515, 252, 518
      Annotation: 
       Subtype: Link
       Rect: 304, 519, 309, 531
       Destination: 663
      Annotation: 
       Subtype: Link
       Rect: 312, 519, 312, 531
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 312, 519, 312, 531
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 312, 519, 316, 531
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 328, 165, 429, 172
      Annotation: 
       Subtype: Link
       Rect: 510, 93, 532, 100
      Annotation: 
       Subtype: Link
       Rect: 303, 85, 449, 92
      Annotation: 
       Subtype: Link
       Rect: 303, 61, 452, 68
      Annotation: 
       Subtype: Link
       Rect: 460, 662, 538, 677
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 91, 536, 286, 545
      Annotation: 
       Subtype: Link
       Rect: 45, 524, 62, 533
      Annotation: 
       Subtype: Link
       Rect: 124, 400, 128, 410
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 183, 375, 187, 385
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 95, 276, 100, 286
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 128, 189, 132, 199
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 184, 164, 196, 174
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 219, 101, 223, 111
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 224, 101, 228, 111
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 341, 707, 349, 716
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 508, 694, 516, 704
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 516, 644, 520, 654
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 332, 582, 353, 592
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 492, 433, 512, 442
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 457, 345, 465, 355
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 321, 296, 329, 306
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 355, 246, 364, 256
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 481, 146, 502, 156
       Destination: 194
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 690, 136, 700
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 185, 285, 280, 295
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 372, 246, 380, 256
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 443, 233, 451, 243
       Destination: 194
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 101, 557, 109, 567
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 141, 236, 232, 246
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 173, 211, 204, 221
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 138, 186, 167, 196
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 197, 148, 229, 158
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 195, 99, 228, 109
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 302, 702, 334, 712
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 332, 621, 425, 631
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 425, 444, 458, 454
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 426, 357, 458, 367
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 387, 319, 419, 329
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 442, 319, 465, 329
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 318, 295, 419, 305
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 442, 257, 474, 267
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 496, 257, 520, 267
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 298, 124, 330, 134
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 351, 124, 373, 134
       Destination: 79
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 131, 142, 218, 152
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 64, 117, 153, 127
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 242, 79, 265, 89
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 301, 677, 393, 687
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 465, 477, 498, 487
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 488, 134, 496, 144
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 185, 508, 188, 516
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 279, 508, 282, 516
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 147, 455, 149, 463
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 191, 424, 194, 432
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 157, 403, 160, 411
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 146, 250, 152, 257
       Destination: 194
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 152, 338, 161, 341
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 231, 77, 239, 81
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 252, 77, 259, 80
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 272, 72, 280, 76
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 379, 75, 387, 78
       Destination: 70
     Rotate: 90
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 190, 486, 198, 496
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 124, 436, 132, 446
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 133, 436, 141, 446
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 503, 498, 510, 508
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 512, 498, 520, 508
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 493, 423, 501, 433
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 416, 349, 424, 359
       Destination: 194
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 400, 84, 410
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 492, 437, 500, 447
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 501, 437, 509, 447
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 422, 425, 434, 435
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 190, 308, 193, 316
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 529, 286, 532, 294
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 190, 189, 193, 197
       Destination: 93
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 570, 84, 579
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 74, 271, 82, 281
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 275, 208, 283, 218
       Destination: 194
      Annotation: 
       Subtype: Link
       Rect: 127, 96, 135, 106
       Destination: 194
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 442, 508, 507, 518
      Annotation: 
       Subtype: Link
       Rect: 298, 496, 494, 506
      Annotation: 
       Subtype: Link
       Rect: 367, 427, 539, 436
      Annotation: 
       Subtype: Link
       Rect: 315, 416, 539, 425
      Annotation: 
       Subtype: Link
       Rect: 315, 405, 354, 414
      Annotation: 
       Subtype: Link
       Rect: 361, 384, 539, 392
      Annotation: 
       Subtype: Link
       Rect: 315, 373, 539, 382
      Annotation: 
       Subtype: Link
       Rect: 315, 362, 388, 371
      Annotation: 
       Subtype: Link
       Rect: 315, 351, 540, 360
      Annotation: 
       Subtype: Link
       Rect: 315, 340, 540, 349
      Annotation: 
       Subtype: Link
       Rect: 315, 329, 540, 338
      Annotation: 
       Subtype: Link
       Rect: 315, 318, 430, 327
      Annotation: 
       Subtype: Link
       Rect: 315, 307, 540, 316
      Annotation: 
       Subtype: Link
       Rect: 315, 296, 540, 305
      Annotation: 
       Subtype: Link
       Rect: 315, 285, 540, 294
      Annotation: 
       Subtype: Link
       Rect: 315, 274, 447, 283
      Annotation: 
       Subtype: Link
       Rect: 454, 274, 540, 283
      Annotation: 
       Subtype: Link
       Rect: 315, 263, 390, 272
      Annotation: 
       Subtype: Link
       Rect: 315, 252, 540, 261
      Annotation: 
       Subtype: Link
       Rect: 315, 241, 540, 250
      Annotation: 
       Subtype: Link
       Rect: 315, 230, 485, 239
      Annotation: 
       Subtype: Link
       Rect: 315, 219, 343, 228
      Annotation: 
       Subtype: Link
       Rect: 347, 219, 540, 228
      Annotation: 
       Subtype: Link
       Rect: 315, 208, 540, 217
      Annotation: 
       Subtype: Link
       Rect: 315, 197, 540, 206
      Annotation: 
       Subtype: Link
       Rect: 315, 186, 540, 195
      Annotation: 
       Subtype: Link
       Rect: 315, 175, 540, 184
      Annotation: 
       Subtype: Link
       Rect: 315, 164, 520, 173
      Annotation: 
       Subtype: Link
       Rect: 315, 153, 540, 162
      Annotation: 
       Subtype: Link
       Rect: 315, 142, 540, 151
      Annotation: 
       Subtype: Link
       Rect: 315, 131, 540, 140
      Annotation: 
       Subtype: Link
       Rect: 315, 121, 540, 129
      Annotation: 
       Subtype: Link
       Rect: 315, 110, 478, 118
      Annotation: 
       Subtype: Link
       Rect: 315, 99, 540, 108
      Annotation: 
       Subtype: Link
       Rect: 315, 88, 540, 97
      Annotation: 
       Subtype: Link
       Rect: 315, 77, 540, 86
      Annotation: 
       Subtype: Link
       Rect: 315, 66, 540, 75
      Annotation: 
       Subtype: Link
       Rect: 315, 55, 477, 64
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 715, 285, 724
      Annotation: 
       Subtype: Link
       Rect: 61, 704, 285, 713
      Annotation: 
       Subtype: Link
       Rect: 61, 694, 285, 702
      Annotation: 
       Subtype: Link
       Rect: 61, 683, 285, 692
      Annotation: 
       Subtype: Link
       Rect: 61, 672, 202, 681
      Annotation: 
       Subtype: Link
       Rect: 61, 661, 285, 670
      Annotation: 
       Subtype: Link
       Rect: 61, 650, 285, 659
      Annotation: 
       Subtype: Link
       Rect: 61, 639, 285, 648
      Annotation: 
       Subtype: Link
       Rect: 61, 628, 285, 637
      Annotation: 
       Subtype: Link
       Rect: 61, 617, 94, 626
      Annotation: 
       Subtype: Link
       Rect: 61, 606, 285, 615
      Annotation: 
       Subtype: Link
       Rect: 61, 595, 285, 604
      Annotation: 
       Subtype: Link
       Rect: 61, 584, 285, 593
      Annotation: 
       Subtype: Link
       Rect: 61, 573, 165, 582
      Annotation: 
       Subtype: Link
       Rect: 61, 562, 285, 571
      Annotation: 
       Subtype: Link
       Rect: 61, 551, 285, 560
      Annotation: 
       Subtype: Link
       Rect: 61, 540, 285, 549
      Annotation: 
       Subtype: Link
       Rect: 61, 529, 285, 538
      Annotation: 
       Subtype: Link
       Rect: 61, 518, 127, 527
      Annotation: 
       Subtype: Link
       Rect: 61, 507, 285, 516
      Annotation: 
       Subtype: Link
       Rect: 61, 496, 285, 505
      Annotation: 
       Subtype: Link
       Rect: 61, 485, 222, 494
      Annotation: 
       Subtype: Link
       Rect: 61, 474, 285, 483
      Annotation: 
       Subtype: Link
       Rect: 61, 463, 285, 472
      Annotation: 
       Subtype: Link
       Rect: 61, 452, 231, 461
      Annotation: 
       Subtype: Link
       Rect: 61, 441, 285, 450
      Annotation: 
       Subtype: Link
       Rect: 61, 430, 285, 439
      Annotation: 
       Subtype: Link
       Rect: 61, 420, 285, 428
      Annotation: 
       Subtype: Link
       Rect: 61, 409, 285, 418
      Annotation: 
       Subtype: Link
       Rect: 61, 398, 136, 407
      Annotation: 
       Subtype: Link
       Rect: 61, 387, 285, 396
      Annotation: 
       Subtype: Link
       Rect: 61, 376, 285, 385
      Annotation: 
       Subtype: Link
       Rect: 61, 365, 285, 374
      Annotation: 
       Subtype: Link
       Rect: 61, 354, 285, 363
      Annotation: 
       Subtype: Link
       Rect: 61, 343, 225, 352
      Annotation: 
       Subtype: Link
       Rect: 61, 332, 285, 341
      Annotation: 
       Subtype: Link
       Rect: 61, 321, 285, 330
      Annotation: 
       Subtype: Link
       Rect: 61, 310, 285, 319
      Annotation: 
       Subtype: Link
       Rect: 61, 299, 253, 308
      Annotation: 
       Subtype: Link
       Rect: 61, 288, 285, 297
      Annotation: 
       Subtype: Link
       Rect: 61, 277, 285, 286
      Annotation: 
       Subtype: Link
       Rect: 61, 266, 285, 275
      Annotation: 
       Subtype: Link
       Rect: 61, 255, 253, 264
      Annotation: 
       Subtype: Link
       Rect: 61, 244, 285, 253
      Annotation: 
       Subtype: Link
       Rect: 61, 233, 285, 242
      Annotation: 
       Subtype: Link
       Rect: 61, 222, 285, 231
      Annotation: 
       Subtype: Link
       Rect: 61, 211, 267, 220
      Annotation: 
       Subtype: Link
       Rect: 61, 200, 285, 209
      Annotation: 
       Subtype: Link
       Rect: 61, 189, 285, 198
      Annotation: 
       Subtype: Link
       Rect: 61, 178, 89, 187
      Annotation: 
       Subtype: Link
       Rect: 96, 178, 285, 187
      Annotation: 
       Subtype: Link
       Rect: 61, 167, 285, 176
      Annotation: 
       Subtype: Link
       Rect: 61, 157, 127, 165
      Annotation: 
       Subtype: Link
       Rect: 61, 146, 285, 155
      Annotation: 
       Subtype: Link
       Rect: 61, 135, 285, 144
      Annotation: 
       Subtype: Link
       Rect: 61, 124, 285, 133
      Annotation: 
       Subtype: Link
       Rect: 61, 113, 285, 122
      Annotation: 
       Subtype: Link
       Rect: 61, 102, 89, 111
      Annotation: 
       Subtype: Link
       Rect: 61, 91, 285, 100
      Annotation: 
       Subtype: Link
       Rect: 61, 80, 285, 89
      Annotation: 
       Subtype: Link
       Rect: 61, 69, 285, 78
      Annotation: 
       Subtype: Link
       Rect: 61, 58, 285, 67
      Annotation: 
       Subtype: Link
       Rect: 314, 715, 538, 724
      Annotation: 
       Subtype: Link
       Rect: 314, 704, 367, 713
      Annotation: 
       Subtype: Link
       Rect: 314, 694, 538, 702
      Annotation: 
       Subtype: Link
       Rect: 314, 683, 538, 692
      Annotation: 
       Subtype: Link
       Rect: 314, 672, 538, 681
      Annotation: 
       Subtype: Link
       Rect: 314, 661, 538, 670
      Annotation: 
       Subtype: Link
       Rect: 314, 650, 491, 659
      Annotation: 
       Subtype: Link
       Rect: 314, 639, 538, 648
      Annotation: 
       Subtype: Link
       Rect: 314, 628, 538, 637
      Annotation: 
       Subtype: Link
       Rect: 314, 617, 538, 626
      Annotation: 
       Subtype: Link
       Rect: 314, 606, 510, 615
      Annotation: 
       Subtype: Link
       Rect: 314, 595, 538, 604
      Annotation: 
       Subtype: Link
       Rect: 314, 584, 538, 593
      Annotation: 
       Subtype: Link
       Rect: 314, 573, 538, 582
      Annotation: 
       Subtype: Link
       Rect: 314, 562, 538, 571
      Annotation: 
       Subtype: Link
       Rect: 314, 551, 445, 560
      Annotation: 
       Subtype: Link
       Rect: 314, 540, 538, 549
      Annotation: 
       Subtype: Link
       Rect: 314, 529, 472, 538
      Annotation: 
       Subtype: Link
       Rect: 314, 518, 538, 527
      Annotation: 
       Subtype: Link
       Rect: 314, 507, 538, 516
      Annotation: 
       Subtype: Link
       Rect: 314, 496, 538, 505
      Annotation: 
       Subtype: Link
       Rect: 314, 485, 415, 494
      Annotation: 
       Subtype: Link
       Rect: 314, 474, 538, 483
      Annotation: 
       Subtype: Link
       Rect: 314, 463, 538, 472
      Annotation: 
       Subtype: Link
       Rect: 314, 452, 538, 461
      Annotation: 
       Subtype: Link
       Rect: 314, 441, 535, 450
      Annotation: 
       Subtype: Link
       Rect: 314, 430, 538, 439
      Annotation: 
       Subtype: Link
       Rect: 314, 420, 538, 428
      Annotation: 
       Subtype: Link
       Rect: 314, 409, 358, 418
      Annotation: 
       Subtype: Link
       Rect: 314, 398, 538, 407
      Annotation: 
       Subtype: Link
       Rect: 314, 387, 538, 396
      Annotation: 
       Subtype: Link
       Rect: 314, 376, 538, 385
      Annotation: 
       Subtype: Link
       Rect: 314, 365, 538, 374
      Annotation: 
       Subtype: Link
       Rect: 314, 354, 488, 363
      Annotation: 
       Subtype: Link
       Rect: 314, 343, 538, 352
      Annotation: 
       Subtype: Link
       Rect: 314, 332, 538, 341
      Annotation: 
       Subtype: Link
       Rect: 314, 321, 538, 330
      Annotation: 
       Subtype: Link
       Rect: 314, 310, 538, 319
      Annotation: 
       Subtype: Link
       Rect: 314, 299, 418, 308
      Annotation: 
       Subtype: Link
       Rect: 314, 288, 538, 297
      Annotation: 
       Subtype: Link
       Rect: 314, 277, 538, 286
      Annotation: 
       Subtype: Link
       Rect: 314, 266, 538, 275
      Annotation: 
       Subtype: Link
       Rect: 314, 255, 444, 264
      Annotation: 
       Subtype: Link
       Rect: 314, 244, 538, 253
      Annotation: 
       Subtype: Link
       Rect: 314, 233, 538, 242
      Annotation: 
       Subtype: Link
       Rect: 314, 222, 538, 231
      Annotation: 
       Subtype: Link
       Rect: 314, 211, 538, 220
      Annotation: 
       Subtype: Link
       Rect: 314, 200, 503, 209
      Annotation: 
       Subtype: Link
       Rect: 314, 189, 538, 198
      Annotation: 
       Subtype: Link
       Rect: 314, 178, 538, 187
      Annotation: 
       Subtype: Link
       Rect: 314, 167, 538, 176
      Annotation: 
       Subtype: Link
       Rect: 314, 157, 381, 165
      Annotation: 
       Subtype: Link
       Rect: 314, 146, 538, 155
      Annotation: 
       Subtype: Link
       Rect: 314, 135, 538, 144
      Annotation: 
       Subtype: Link
       Rect: 314, 124, 538, 133
      Annotation: 
       Subtype: Link
       Rect: 314, 113, 538, 122
      Annotation: 
       Subtype: Link
       Rect: 314, 102, 409, 111
      Annotation: 
       Subtype: Link
       Rect: 314, 91, 538, 100
      Annotation: 
       Subtype: Link
       Rect: 314, 80, 538, 89
      Annotation: 
       Subtype: Link
       Rect: 314, 69, 538, 78
      Annotation: 
       Subtype: Link
       Rect: 314, 58, 333, 67
  Checksum: d8e2c1ac
   Type: CRC32
  Checksum: f7e9a3057cfb9e45735ea4efef8df169
   Type: MD5
  Checksum: 23580c843052a0f7c3b53d2ac74adecb8ff19dcd
   Type: SHA-1
  Checksum: d34f6d75aa6aac66e9c502b3c573d80a1ebe3b068b6b5b2700317c76447cd059
   Type: SHA-256