773a3abf3534285104cdcd795fc0d691 309321.pdf 054f94fc55fbc1addef178afb982a0bdfaba4b23 309321.pdf 7e63a435c0ba64b240367a03a3a4fff0bdafa787276d05b215465ac1c4e1f10c 309321.pdf Title: Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFR Mutation-Positive Advanced NSCLC Progression During Treatment: Data From FLAURA and AURA3 Subject: Journal of Thoracic Oncology, 19 (2024) 1525-1538. doi:10.1016/j.jtho.2024.07.008 Author: Jhanelle E. Gray MD Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 16 18:20:18 2024 CEST ModDate: Wed Oct 16 18:22:05 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 543528 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OKBNDN+AdvPSSym Type 1C Custom yes yes yes 824 0 OKBNAE+AdvTTc9c3bd71 Type 1C WinAnsi yes yes no 794 0 OKBNBE+AdvTT7f5838b0.I Type 1C WinAnsi yes yes no 800 0 OKBNCF+AdvTT7f5838b0.I+fb Type 1C Custom yes yes yes 812 0 OKBNCG+AdvTT7f5838b0.I+20 Type 1C WinAnsi yes yes no 815 0 OKBNCH+AdvTT0eeac7f7.B Type 1C WinAnsi yes yes no 818 0 OKBNCI+AdvTT08640291 Type 1C WinAnsi yes yes no 803 0 OKBNCJ+AdvTT08640291+fb Type 1C Custom yes yes yes 808 0 OKBNCK+AdvTT9cc80a3e.I Type 1C WinAnsi yes yes no 816 0 OKBNCL+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 833 0 OKBNCM+AdvTTda6f6cb8.B+fb Type 1C Custom yes yes yes 828 0 OKBNCN+AdvTT43930a72.BI Type 1C WinAnsi yes yes no 830 0 OKBNGN+AdvP4C4E74 Type 1C Custom yes yes yes 484 0 OKBNGO+AdvTT08640291+20 Type 1C WinAnsi yes yes no 483 0 OKBNHP+AdvP4C4E51 Type 1C WinAnsi yes yes no 486 0 OKBNJA+AdvTT5843c571 Type 1C WinAnsi yes yes no 492 0 OKBNLA+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 498 0 OKBNMA+AdvTTc9c3bd71+fb Type 1C Custom yes yes yes 496 0 OKBOBE+AdvTTc9c3bd71+20 Type 1C WinAnsi yes yes no 512 0 OKBNPA+ArialMT CID TrueType Identity-H yes yes yes 516 0 OKBOBC+Arial-ItalicMT TrueType WinAnsi yes yes no 517 0 OKBOBD+Arial-BoldMT CID TrueType Identity-H yes yes yes 507 0 OKBOLB+AdvPS3FDD77 Type 1C WinAnsi yes yes no 528 0 OKBPBA+AdvPS44A44B Type 1C WinAnsi yes yes no 534 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-03 02:47:46 CEST RepresentationInformation: 309321.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-02 08:26:34 CEST Size: 543528 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-122 Offset: 511484 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 511484 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 891 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFR Mutation-Positive Advanced NSCLC Progression Durin ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Materials and Methods Destination: flink2 Children: Item: Title: Trial Designs Destination: slink1 Item: Title: Objectives Destination: slink2 Item: Title: Participants Destination: slink3 Item: Title: Sampling and Testing Destination: slink4 Item: Title: Assessments Destination: slink5 Item: Title: Statistics Destination: slink6 Item: Title: Results Destination: flink3 Children: Item: Title: Patient Disposition (FLAURA and AURA3) Destination: slink7 Item: Title: Patient Demographics and Disease Characteristics (FLAURA and AURA3) Destination: slink8 Item: Title: ctDNA Disease Progression Analysis Destination: slink9 Children: Item: Title: Lead Time From ctDNA PD to FST (FLAURA Only) Destination: thirlink1 Item: Title: Lead Time From ctDNA PD to RECIST PD (FLAURA and AURA3) Destination: thirlink2 Item: Title: ctDNA Resistance Analysis Destination: slink10 Children: Item: Title: Lead Time From ctDNA Resistance Detection to FST (FLAURA Only) Destination: thirlink3 Item: Title: Lead Time From ctDNA Resistance Detection to RECIST PD (FLAURA and AURA3) Destination: thirlink4 Item: Title: Discussion Destination: flink4 Item: Title: Data Availability Statement Destination: flink5 Item: Title: CRediT Authorship Contribution Statement Destination: flink6 Item: Title: flink7 Destination: flink7 Item: Title: flink8 Destination: flink8 Item: Title: Supplementary Data Destination: flink9 Item: Title: References Destination: blink1 Info: Title: Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFR Mutation-Positive Advanced NSCLC Progression During Treatment: Data From FLAURA and AURA3 Author: Jhanelle E. Gray MD Subject: Journal of Thoracic Oncology, 19 (2024) 1525-1538. doi:10.1016/j.jtho.2024.07.008 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 16 18:50:18 CEST 2024 ModDate: Wed Oct 16 18:52:05 CEST 2024 ID: 0x3cdea7e1dbfab4c5adb52422fb1f3514, 0xeaedb4f1a3b14e46b25595215f4a1233 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: OKBNPA+ArialMT Encoding: Identity-H ToUnicode: true Font: BaseFont: OKBOBD+Arial-BoldMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OKBNBE+AdvTT7f5838b0.I FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: OKBNBE+AdvTT7f5838b0.I Flags: Nonsymbolic FontBBox: -62, -218, 927, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBOBE+AdvTTc9c3bd71+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: OKBOBE+AdvTTc9c3bd71+20 Flags: Nonsymbolic FontBBox: 0, -239, 1072, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCL+AdvTTda6f6cb8.B FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: OKBNCL+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCI+AdvTT08640291 FontSubset: true FirstChar: 37 LastChar: 239 FontDescriptor: FontName: OKBNCI+AdvTT08640291 Flags: Serif, Nonsymbolic FontBBox: 0, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNGO+AdvTT08640291+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OKBNGO+AdvTT08640291+20 Flags: Nonsymbolic FontBBox: -187, -197, 1208, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNGN+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: OKBNGN+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBNHP+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OKBNHP+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCJ+AdvTT08640291+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OKBNCJ+AdvTT08640291+fb Flags: Symbolic FontBBox: 30, 0, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBNCF+AdvTT7f5838b0.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OKBNCF+AdvTT7f5838b0.I+fb Flags: Symbolic FontBBox: -41, -197, 1354, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBNJA+AdvTT5843c571 FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: OKBNJA+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCG+AdvTT7f5838b0.I+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OKBNCG+AdvTT7f5838b0.I+20 Flags: Nonsymbolic FontBBox: -10, -239, 1104, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCK+AdvTT9cc80a3e.I FontSubset: true FirstChar: 58 LastChar: 121 FontDescriptor: FontName: OKBNCK+AdvTT9cc80a3e.I Flags: Nonsymbolic FontBBox: -125, -208, 979, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNMA+AdvTTc9c3bd71+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OKBNMA+AdvTTc9c3bd71+fb Flags: Symbolic FontBBox: 9, -197, 1302, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBOLB+AdvPS3FDD77 FontSubset: true FirstChar: 119 LastChar: 119 FontDescriptor: FontName: OKBOLB+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCH+AdvTT0eeac7f7.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: OKBNCH+AdvTT0eeac7f7.B Flags: Nonsymbolic FontBBox: 0, -218, 958, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNLA+AdvOTb0c9bf5d FontSubset: true FirstChar: 177 LastChar: 177 FontDescriptor: FontName: OKBNLA+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBPBA+AdvPS44A44B FontSubset: true FirstChar: 101 LastChar: 101 FontDescriptor: FontName: OKBPBA+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNDN+AdvPSSym FontSubset: true FirstChar: 2 LastChar: 170 FontDescriptor: FontName: OKBNDN+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBNAE+AdvTTc9c3bd71 FontSubset: true FirstChar: 37 LastChar: 237 FontDescriptor: FontName: OKBNAE+AdvTTc9c3bd71 Flags: Nonsymbolic FontBBox: -31, -218, 843, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKBNCM+AdvTTda6f6cb8.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OKBNCM+AdvTTda6f6cb8.B+fb Flags: Symbolic FontBBox: 9, -197, 1385, 760 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OKBNCN+AdvTT43930a72.BI FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OKBNCN+AdvTT43930a72.BI Flags: Nonsymbolic FontBBox: -72, -218, 979, 937 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: OKBOBC+Arial-ItalicMT FontSubset: true FirstChar: 69 LastChar: 82 FontDescriptor: FontName: OKBOBC+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: OKBNPA+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OKBNPA+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true Font: BaseFont: OKBOBD+Arial-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OKBOBD+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile2: true XMP: application/pdf doi:10.1016/j.jtho.2024.07.008 Longitudinal Analyses of Circulating Tumor DNA for the Detection of EGFR Mutation-Positive Advanced NSCLC Progression During Treatment: Data From FLAURA and AURA3 Jhanelle E. Gray MD Aleksandra Markovets PhD Thanyanan Reungwetwattana MD MSc Margarita Majem MD PhD Naoyuki Nogami MD PhD Nir Peled MD PhD Jong-Seok Lee MD Byoung Chul Cho MD PhD Busayamas Chewaskulyong MD Tom John MD PhD Ji-Youn Han MD PhD Martin Sebastian MD Alexander Todd MSc Yuri Rukazenkov MD PhD Carl Barrett PhD Juliann Chmielecki PhD Siow Ming Lee PhD FRCP Suresh S. Ramalingam MD Ryan Hartmaier PhD Circulating tumor DNA EGFR mutations Non-small cell lung cancer Osimertinib Resistance Journal of Thoracic Oncology, 19 (2024) 1525-1538. doi:10.1016/j.jtho.2024.07.008 International Association for the Study of Lung Cancer journal Journal of Thoracic Oncology © 2024 International Association for the Study of Lung Cancer. Published by Elsevier Inc. 1556-0864 19 11 November 2024 1525-1538 1525 1538 10.1016/j.jtho.2024.07.008 https://doi.org/10.1016/j.jtho.2024.07.008 2010-04-23 true 10.1016/j.jtho.2024.07.008 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.jtho.2024.07.008 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2024-10-16T21:50:18+05:30 2024-10-16T21:52:05+05:30 2024-10-16T21:52:05+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:02a17710-f670-443e-b52e-3f71296e0a2f uuid:5ac6adaa-6f87-4256-a05e-703793082f05 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1525 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 159, 580, 164, 592 Destination: 715 Annotation: Subtype: Link Rect: 316, 580, 321, 592 Destination: 715 Annotation: Subtype: Link Rect: 258, 567, 262, 579 Destination: 715 Annotation: Subtype: Link Rect: 265, 567, 265, 579 Destination: null Annotation: Subtype: Link Rect: 265, 567, 265, 579 Destination: null Annotation: Subtype: Link Rect: 265, 567, 269, 579 Destination: null Annotation: Subtype: Link Rect: 420, 567, 424, 579 Destination: 715 Annotation: Subtype: Link Rect: 186, 553, 191, 565 Destination: 715 Annotation: Subtype: Link Rect: 300, 553, 303, 565 Destination: 715 Annotation: Subtype: Link Rect: 412, 553, 416, 565 Destination: 715 Annotation: Subtype: Link Rect: 190, 539, 195, 551 Destination: 715 Annotation: Subtype: Link Rect: 368, 539, 371, 551 Destination: 715 Annotation: Subtype: Link Rect: 481, 539, 485, 551 Destination: 715 Annotation: Subtype: Link Rect: 163, 525, 168, 537 Destination: 715 Annotation: Subtype: Link Rect: 288, 525, 291, 537 Destination: 715 Annotation: Subtype: Link Rect: 410, 525, 417, 537 Destination: 715 Annotation: Subtype: Link Rect: 186, 511, 190, 523 Destination: 715 Annotation: Subtype: Link Rect: 290, 511, 295, 523 Destination: 715 Annotation: Subtype: Link Rect: 432, 511, 437, 523 Destination: 715 Annotation: Subtype: Link Rect: 185, 497, 190, 509 Destination: 715 Annotation: Subtype: Link Rect: 339, 497, 344, 509 Destination: 715 Annotation: Subtype: Link Rect: 458, 497, 463, 509 Destination: 715 Annotation: Subtype: Link Rect: 328, 157, 426, 164 Annotation: Subtype: Link Rect: 378, 93, 532, 100 Annotation: Subtype: Link Rect: 303, 85, 317, 92 Annotation: Subtype: Link Rect: 303, 61, 446, 68 Annotation: Subtype: Link Rect: 460, 662, 538, 677 Page: Label: 1526 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 172, 386, 286, 396 Annotation: Subtype: Link Rect: 45, 374, 135, 384 Annotation: Subtype: Link Rect: 203, 221, 207, 231 Destination: 155 Annotation: Subtype: Link Rect: 275, 196, 286, 206 Destination: 155 Annotation: Subtype: Link Rect: 79, 146, 84, 156 Destination: 155 Annotation: Subtype: Link Rect: 282, 121, 286, 131 Destination: 155 Annotation: Subtype: Link Rect: 241, 59, 245, 69 Destination: 155 Annotation: Subtype: Link Rect: 480, 694, 484, 704 Destination: 155 Annotation: Subtype: Link Rect: 535, 657, 540, 667 Destination: 155 Annotation: Subtype: Link Rect: 470, 607, 474, 617 Destination: 155 Annotation: Subtype: Link Rect: 487, 557, 491, 567 Destination: 155 Annotation: Subtype: Link Rect: 460, 532, 464, 542 Destination: 155 Annotation: Subtype: Link Rect: 495, 445, 499, 455 Destination: 155 Annotation: Subtype: Link Rect: 500, 445, 508, 455 Destination: 155 Annotation: Subtype: Link Rect: 493, 383, 502, 393 Destination: 155 Annotation: Subtype: Link Rect: 430, 345, 439, 355 Destination: 155 Annotation: Subtype: Link Rect: 456, 308, 464, 318 Destination: 155 Annotation: Subtype: Link Rect: 419, 59, 423, 69 Destination: 155 Annotation: Subtype: Link Rect: 425, 59, 429, 69 Destination: 155 Page: Label: 1527 Sequence: 3 Page: Label: 1528 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 49, 602, 81, 612 Destination: 30 Annotation: Subtype: Link Rect: 132, 590, 237, 600 Destination: null Annotation: Subtype: Link Rect: 456, 665, 479, 675 Destination: 48 Annotation: Subtype: Link Rect: 362, 578, 385, 588 Destination: 48 Annotation: Subtype: Link Rect: 298, 487, 403, 497 Destination: null Annotation: Subtype: Link Rect: 425, 487, 431, 497 Destination: null Annotation: Subtype: Link Rect: 434, 449, 539, 459 Destination: null Annotation: Subtype: Link Rect: 317, 437, 323, 447 Destination: null Annotation: Subtype: Link Rect: 475, 360, 539, 370 Destination: null Annotation: Subtype: Link Rect: 298, 347, 331, 357 Destination: null Annotation: Subtype: Link Rect: 367, 260, 391, 270 Destination: 57 Annotation: Subtype: Link Rect: 341, 248, 377, 258 Destination: 57 Annotation: Subtype: Link Rect: 406, 248, 510, 258 Destination: null Page: Label: 1529 Sequence: 5 Page: Label: 1530 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 302, 79, 326, 89 Destination: 69 Annotation: Subtype: Link Rect: 379, 54, 403, 64 Destination: 69 Annotation: Subtype: Link Rect: 431, 54, 523, 64 Destination: null Page: Label: 1531 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 48, 690, 153, 700 Destination: null Annotation: Subtype: Link Rect: 501, 627, 527, 637 Destination: 69 Page: Label: 1532 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 88, 702, 113, 712 Destination: 69 Annotation: Subtype: Link Rect: 397, 627, 421, 637 Destination: 80 Annotation: Subtype: Link Rect: 340, 602, 375, 612 Destination: 80 Annotation: Subtype: Link Rect: 402, 602, 502, 612 Destination: null Page: Label: 1533 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 176, 553, 198, 563 Destination: 93 Annotation: Subtype: Link Rect: 243, 540, 280, 550 Destination: 93 Annotation: Subtype: Link Rect: 63, 528, 165, 538 Destination: null Annotation: Subtype: Link Rect: 44, 391, 138, 401 Destination: null Annotation: Subtype: Link Rect: 430, 617, 451, 627 Destination: 155 Annotation: Subtype: Link Rect: 324, 455, 333, 465 Destination: 155 Annotation: Subtype: Link Rect: 334, 455, 342, 465 Destination: 155 Page: Label: 1534 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 164, 507, 173, 517 Destination: 155 Annotation: Subtype: Link Rect: 151, 308, 160, 318 Destination: 155 Annotation: Subtype: Link Rect: 161, 308, 169, 318 Destination: 155 Annotation: Subtype: Link Rect: 223, 258, 231, 268 Destination: 155 Annotation: Subtype: Link Rect: 233, 258, 241, 268 Destination: 155 Annotation: Subtype: Link Rect: 216, 159, 225, 169 Destination: 155 Annotation: Subtype: Link Rect: 404, 607, 412, 617 Destination: 155 Annotation: Subtype: Link Rect: 496, 594, 504, 604 Destination: 155 Annotation: Subtype: Link Rect: 506, 594, 514, 604 Destination: 155 Annotation: Subtype: Link Rect: 433, 520, 442, 530 Destination: 381 Annotation: Subtype: Link Rect: 370, 445, 390, 455 Destination: 381 Annotation: Subtype: Link Rect: 439, 146, 448, 156 Destination: 381 Annotation: Subtype: Link Rect: 449, 146, 458, 156 Destination: 381 Annotation: Subtype: Link Rect: 467, 96, 487, 106 Destination: 381 Annotation: Subtype: Link Rect: 325, 59, 333, 69 Destination: 155 Page: Label: 1535 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 160, 682, 168, 692 Destination: 381 Annotation: Subtype: Link Rect: 48, 615, 154, 625 Destination: null Annotation: Subtype: Link Rect: 497, 682, 501, 692 Destination: 155 Annotation: Subtype: Link Rect: 505, 489, 538, 499 Annotation: Subtype: Link Rect: 297, 477, 538, 487 Annotation: Subtype: Link Rect: 297, 464, 342, 474 Annotation: Subtype: Link Rect: 414, 439, 473, 449 Annotation: Subtype: Link Rect: 378, 414, 538, 424 Annotation: Subtype: Link Rect: 297, 402, 496, 412 Annotation: Subtype: Link Rect: 410, 377, 538, 387 Annotation: Subtype: Link Rect: 297, 365, 352, 375 Page: Label: 1536 Sequence: 12 Page: Label: 1537 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 124, 677, 267, 687 Annotation: Subtype: Link Rect: 143, 608, 195, 618 Annotation: Subtype: Link Rect: 236, 608, 285, 618 Annotation: Subtype: Link Rect: 44, 596, 180, 605 Annotation: Subtype: Link Rect: 61, 550, 285, 559 Annotation: Subtype: Link Rect: 61, 539, 285, 548 Annotation: Subtype: Link Rect: 61, 528, 285, 537 Annotation: Subtype: Link Rect: 61, 517, 162, 526 Annotation: Subtype: Link Rect: 61, 506, 285, 515 Annotation: Subtype: Link Rect: 61, 495, 285, 504 Annotation: Subtype: Link Rect: 61, 484, 222, 493 Annotation: Subtype: Link Rect: 61, 474, 285, 482 Annotation: Subtype: Link Rect: 61, 463, 285, 472 Annotation: Subtype: Link Rect: 61, 452, 285, 461 Annotation: Subtype: Link Rect: 61, 441, 285, 450 Annotation: Subtype: Link Rect: 61, 430, 80, 439 Annotation: Subtype: Link Rect: 61, 419, 285, 428 Annotation: Subtype: Link Rect: 61, 408, 285, 417 Annotation: Subtype: Link Rect: 61, 397, 162, 406 Annotation: Subtype: Link Rect: 61, 386, 285, 395 Annotation: Subtype: Link Rect: 61, 375, 285, 384 Annotation: Subtype: Link Rect: 61, 364, 285, 373 Annotation: Subtype: Link Rect: 61, 353, 285, 362 Annotation: Subtype: Link Rect: 61, 342, 285, 351 Annotation: Subtype: Link Rect: 61, 331, 123, 340 Annotation: Subtype: Link Rect: 61, 320, 285, 329 Annotation: Subtype: Link Rect: 61, 309, 285, 318 Annotation: Subtype: Link Rect: 61, 298, 285, 307 Annotation: Subtype: Link Rect: 61, 287, 122, 296 Annotation: Subtype: Link Rect: 61, 276, 285, 285 Annotation: Subtype: Link Rect: 61, 265, 285, 274 Annotation: Subtype: Link Rect: 61, 254, 285, 263 Annotation: Subtype: Link Rect: 61, 243, 285, 252 Annotation: Subtype: Link Rect: 61, 232, 220, 241 Annotation: Subtype: Link Rect: 61, 221, 285, 230 Annotation: Subtype: Link Rect: 61, 210, 285, 219 Annotation: Subtype: Link Rect: 61, 200, 285, 208 Annotation: Subtype: Link Rect: 61, 189, 70, 198 Annotation: Subtype: Link Rect: 61, 178, 285, 187 Annotation: Subtype: Link Rect: 61, 167, 285, 176 Annotation: Subtype: Link Rect: 61, 156, 285, 165 Annotation: Subtype: Link Rect: 61, 145, 190, 154 Annotation: Subtype: Link Rect: 61, 134, 285, 143 Annotation: Subtype: Link Rect: 61, 123, 285, 132 Annotation: Subtype: Link Rect: 61, 112, 177, 121 Annotation: Subtype: Link Rect: 61, 101, 285, 110 Annotation: Subtype: Link Rect: 61, 90, 285, 99 Annotation: Subtype: Link Rect: 61, 79, 285, 88 Annotation: Subtype: Link Rect: 61, 68, 285, 77 Annotation: Subtype: Link Rect: 61, 57, 285, 66 Annotation: Subtype: Link Rect: 314, 715, 538, 724 Annotation: Subtype: Link Rect: 314, 704, 493, 713 Annotation: Subtype: Link Rect: 314, 694, 538, 702 Annotation: Subtype: Link Rect: 314, 683, 538, 692 Annotation: Subtype: Link Rect: 314, 672, 538, 681 Annotation: Subtype: Link Rect: 314, 661, 538, 670 Annotation: Subtype: Link Rect: 314, 650, 329, 659 Annotation: Subtype: Link Rect: 314, 639, 538, 648 Annotation: Subtype: Link Rect: 314, 628, 538, 637 Annotation: Subtype: Link Rect: 314, 617, 538, 626 Annotation: Subtype: Link Rect: 314, 606, 538, 615 Annotation: Subtype: Link Rect: 314, 595, 538, 604 Annotation: Subtype: Link Rect: 314, 584, 333, 593 Annotation: Subtype: Link Rect: 314, 573, 538, 582 Annotation: Subtype: Link Rect: 314, 562, 538, 571 Annotation: Subtype: Link Rect: 314, 551, 501, 560 Annotation: Subtype: Link Rect: 314, 540, 538, 549 Annotation: Subtype: Link Rect: 314, 529, 538, 538 Annotation: Subtype: Link Rect: 314, 518, 328, 527 Annotation: Subtype: Link Rect: 314, 507, 538, 516 Annotation: Subtype: Link Rect: 314, 496, 538, 505 Annotation: Subtype: Link Rect: 314, 485, 538, 494 Annotation: Subtype: Link Rect: 314, 474, 538, 483 Annotation: Subtype: Link Rect: 314, 463, 493, 472 Annotation: Subtype: Link Rect: 314, 452, 538, 461 Annotation: Subtype: Link Rect: 314, 441, 538, 450 Annotation: Subtype: Link Rect: 314, 430, 538, 439 Annotation: Subtype: Link Rect: 314, 420, 538, 428 Annotation: Subtype: Link Rect: 314, 409, 363, 418 Annotation: Subtype: Link Rect: 314, 398, 538, 407 Annotation: Subtype: Link Rect: 314, 387, 538, 396 Annotation: Subtype: Link Rect: 314, 376, 420, 385 Annotation: Subtype: Link Rect: 314, 365, 538, 374 Annotation: Subtype: Link Rect: 314, 354, 538, 363 Annotation: Subtype: Link Rect: 314, 343, 538, 352 Annotation: Subtype: Link Rect: 314, 332, 408, 341 Annotation: Subtype: Link Rect: 314, 321, 538, 330 Annotation: Subtype: Link Rect: 314, 310, 538, 319 Annotation: Subtype: Link Rect: 314, 299, 538, 308 Annotation: Subtype: Link Rect: 314, 288, 409, 297 Annotation: Subtype: Link Rect: 314, 277, 538, 286 Annotation: Subtype: Link Rect: 314, 266, 538, 275 Annotation: Subtype: Link Rect: 314, 255, 538, 264 Annotation: Subtype: Link Rect: 314, 244, 522, 253 Annotation: Subtype: Link Rect: 314, 233, 538, 242 Annotation: Subtype: Link Rect: 314, 222, 538, 231 Annotation: Subtype: Link Rect: 314, 211, 538, 220 Annotation: Subtype: Link Rect: 314, 200, 538, 209 Annotation: Subtype: Link Rect: 314, 189, 538, 198 Annotation: Subtype: Link Rect: 314, 178, 439, 187 Annotation: Subtype: Link Rect: 314, 167, 538, 176 Annotation: Subtype: Link Rect: 314, 157, 538, 165 Annotation: Subtype: Link Rect: 314, 146, 538, 155 Annotation: Subtype: Link Rect: 314, 135, 408, 144 Annotation: Subtype: Link Rect: 314, 124, 538, 133 Annotation: Subtype: Link Rect: 314, 113, 538, 122 Annotation: Subtype: Link Rect: 314, 102, 538, 111 Annotation: Subtype: Link Rect: 314, 91, 494, 100 Annotation: Subtype: Link Rect: 314, 80, 538, 89 Annotation: Subtype: Link Rect: 314, 69, 538, 78 Annotation: Subtype: Link Rect: 314, 58, 509, 67 Page: Label: 1538 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 62, 715, 286, 724 Annotation: Subtype: Link Rect: 62, 704, 286, 713 Annotation: Subtype: Link Rect: 62, 694, 286, 702 Annotation: Subtype: Link Rect: 62, 683, 235, 692 Annotation: Subtype: Link Rect: 62, 672, 286, 681 Annotation: Subtype: Link Rect: 62, 661, 286, 670 Annotation: Subtype: Link Rect: 62, 650, 286, 659 Annotation: Subtype: Link Rect: 62, 639, 286, 648 Annotation: Subtype: Link Rect: 62, 628, 286, 637 Annotation: Subtype: Link Rect: 62, 617, 82, 626 Annotation: Subtype: Link Rect: 62, 606, 286, 615 Annotation: Subtype: Link Rect: 62, 595, 286, 604 Annotation: Subtype: Link Rect: 62, 584, 286, 593 Annotation: Subtype: Link Rect: 62, 573, 203, 582 Annotation: Subtype: Link Rect: 62, 562, 286, 571 Annotation: Subtype: Link Rect: 62, 551, 286, 560 Annotation: Subtype: Link Rect: 62, 540, 286, 549 Annotation: Subtype: Link Rect: 62, 529, 76, 538 Annotation: Subtype: Link Rect: 62, 518, 286, 527 Annotation: Subtype: Link Rect: 62, 507, 286, 516 Annotation: Subtype: Link Rect: 62, 496, 286, 505 Annotation: Subtype: Link Rect: 62, 485, 286, 494 Annotation: Subtype: Link Rect: 62, 474, 133, 483 Annotation: Subtype: Link Rect: 315, 715, 540, 724 Annotation: Subtype: Link Rect: 315, 704, 540, 713 Annotation: Subtype: Link Rect: 315, 694, 540, 702 Annotation: Subtype: Link Rect: 315, 683, 393, 692 Annotation: Subtype: Link Rect: 315, 672, 540, 681 Annotation: Subtype: Link Rect: 315, 661, 540, 670 Annotation: Subtype: Link Rect: 315, 650, 540, 659 Annotation: Subtype: Link Rect: 315, 639, 390, 648 Annotation: Subtype: Link Rect: 315, 628, 511, 637 Annotation: Subtype: Link Rect: 518, 628, 540, 637 Annotation: Subtype: Link Rect: 315, 617, 430, 626 Annotation: Subtype: Link Rect: 315, 606, 540, 615 Annotation: Subtype: Link Rect: 315, 595, 540, 604 Annotation: Subtype: Link Rect: 315, 584, 540, 593 Annotation: Subtype: Link Rect: 315, 573, 540, 582 Annotation: Subtype: Link Rect: 315, 562, 540, 571 Annotation: Subtype: Link Rect: 315, 551, 329, 560 Annotation: Subtype: Link Rect: 315, 540, 540, 549 Annotation: Subtype: Link Rect: 315, 529, 540, 538 Annotation: Subtype: Link Rect: 315, 518, 540, 527 Annotation: Subtype: Link Rect: 315, 507, 390, 516 Annotation: Subtype: Link Rect: 315, 496, 540, 505 Annotation: Subtype: Link Rect: 315, 485, 540, 494 Annotation: Subtype: Link Rect: 315, 474, 460, 483 Checksum: 03e235db Type: CRC32 Checksum: 773a3abf3534285104cdcd795fc0d691 Type: MD5 Checksum: 054f94fc55fbc1addef178afb982a0bdfaba4b23 Type: SHA-1 Checksum: 7e63a435c0ba64b240367a03a3a4fff0bdafa787276d05b215465ac1c4e1f10c Type: SHA-256