7080b8cbff66a728e887f9f68b5369dc 309329.pdf f8a0725a562ec4e8751d20a8580f1180ef7733b9 309329.pdf ec1b2da8569340a8a0c9341c1f07091eaa190824175e81b30e8fa87ff289a9b5 309329.pdf Title: Empagliflozin in acute myocardial infarction in patients with and without type 2 diabetes: A pre‐specified analysis of the EMPACT‐MI trial Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 25.0 (Windows) CreationDate: Wed Mar 26 06:15:00 2025 CET ModDate: Wed Mar 26 06:15:00 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 819811 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GillSansStd Type 1C Custom yes no yes 355 0 GillSansStd-Bold Type 1C Custom yes no yes 356 0 UniversLTStd Type 1C Custom yes no yes 357 0 UniversLTStd-Bold Type 1C Custom yes no yes 358 0 STIXMath-Bold Type 1C Custom yes no yes 359 0 GillSansStd-Italic Type 1C Custom yes no yes 360 0 UniversLTStd-Obl Type 1C Custom yes no yes 361 0 STIXMath-Italic Type 1C Custom yes no yes 362 0 STIXMath-Regular Type 1C Custom yes no yes 363 0 GMDMKE+HelveticaLTStd-Roman Type 1C Custom yes yes yes 163 0 STIXMathCalligraphy-Regular Type 1C Custom yes no yes 164 0 GillSansStd-BoldItalic Type 1C Custom yes no yes 165 0 GMDPME+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 166 0 HelveticaLTStd-BoldObl Type 1C WinAnsi yes no no 167 0 GMEBKL+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 168 0 GMEBKM+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 169 0 HelveticaLTStd-BoldObl Type 1C WinAnsi yes no no 70 0 HelveticaLTStd-Obl Type 1C WinAnsi yes no no 83 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-24 02:40:35 CEST RepresentationInformation: 309329.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-23 14:05:08 CEST Size: 819811 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0004' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0003' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-supitem-0003' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-supitem-0004' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0008' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0009' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0007' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-note-0010' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ejhf3548-supitem-0002' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0004' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0009' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0008' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-supitem-0004' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-supitem-0002' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0007' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-supitem-0003' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0010' cannot be found ID: PDF-HUL-122 Offset: 807675 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3548-note-0003' cannot be found ID: PDF-HUL-122 Offset: 807675 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 400 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Empagliflozin in acute myocardial infarction in patients with and without type 2 diabetes: A pre-specified analysis of the EMPACT-MI trial Destination: section*.1 Item: Title: Introduction Destination: section*.2 Item: Title: Methods Destination: section*.3 Item: Title: Study design and participants Destination: section*.4 Item: Title: Categorization of glycaemic status at baseline Destination: section*.5 Item: Title: Endpoints Destination: section*.6 Item: Title: Statistics Destination: section*.7 Item: Title: Results Destination: section*.8 Item: Title: Glycaemia status at baseline (over pooled empagliflozin and placebo groups) Destination: section*.9 Item: Title: Outcomes in the placebo group according to type 2 diabetes status Destination: section*.10 Item: Title: Effect of empagliflozin according to type 2 diabetes status Destination: section*.11 Item: Title: Safety Destination: section*.12 Item: Title: Discussion Destination: section*.13 Item: Title: Supplementary Information Destination: section*.14 Item: Title: Funding Destination: section*.15 Item: Title: References Destination: ssectioncnt.1 Info: Title: Empagliflozin in acute myocardial infarction in patients with and without type 2 diabetes: A pre‐specified analysis of the EMPACT‐MI trial Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 25.0 (Windows) CreationDate: Wed Mar 26 06:45:00 CET 2025 ModDate: Wed Mar 26 06:45:00 CET 2025 ID: 0xceda9a7da53b7f005df8d4c49aba30a8, 0x77f542eb486753e7acb80f2ba94d0049 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GillSansStd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GillSansStd Flags: Symbolic FontBBox: -162, -250, 1041, 911 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GMDMKE+HelveticaLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 133 FontDescriptor: FontName: GMDMKE+HelveticaLTStd-Roman Flags: Symbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GillSansStd-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GillSansStd-Bold Flags: Symbolic, ForceBold FontBBox: -177, -250, 1167, 929 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: STIXMathCalligraphy-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIXMathCalligraphy-Regular Flags: Symbolic FontBBox: 63, -103, 629, 609 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: UniversLTStd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GillSansStd-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GillSansStd-BoldItalic Flags: Symbolic, Italic, ForceBold FontBBox: -190, -250, 1074, 915 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: UniversLTStd-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UniversLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -167, -250, 995, 938 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GMDPME+HelveticaLTStd-Bold FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GMDPME+HelveticaLTStd-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HelveticaLTStd-BoldObl FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaLTStd-BoldObl Flags: Nonsymbolic, Italic, ForceBold FontBBox: -174, -228, 1114, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: STIXMath-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIXMath-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -998, -341, 1306, 1055 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HelveticaLTStd-BoldObl FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaLTStd-BoldObl Flags: Nonsymbolic, Italic, ForceBold FontBBox: -174, -228, 1114, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GillSansStd-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GillSansStd-Italic Flags: Symbolic, Italic FontBBox: -201, -250, 1009, 909 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GMEBKL+HelveticaLTStd-Roman FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GMEBKL+HelveticaLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: UniversLTStd-Obl FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UniversLTStd-Obl Flags: Symbolic, Italic FontBBox: -174, -272, 1145, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GMEBKM+HelveticaLTStd-Bold FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: GMEBKM+HelveticaLTStd-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: STIXMath-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIXMath-Italic Flags: Symbolic, Italic FontBBox: 69, -11, 181, 100 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: STIXMath-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIXMath-Regular Flags: Serif, Symbolic FontBBox: -970, -341, 1096, 1023 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HelveticaLTStd-Obl FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HelveticaLTStd-Obl Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding XMP: VoR 10.1002/ejhf.3548 10.1002/ejhf.3548 10.1002/(ISSN)1879-0844 3 Empagliflozin in acute myocardial infarction in patients with and without type 2 diabetes: A pre‐specified analysis of the EMPACT‐MI trial Pages: Page: Label: D Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 230, 25, 340, 33 Thumb: true Page: Label: D Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 275, 204, 285, 213 Destination: 105 Annotation: Subtype: Link Rect: 234, 72, 240, 81 Destination: 105 Annotation: Subtype: Link Rect: 526, 238, 531, 247 Destination: 105 Annotation: Subtype: Link Rect: 478, 226, 484, 235 Destination: 105 Annotation: Subtype: Link Rect: 460, 191, 465, 200 Destination: 105 Annotation: Subtype: Link Rect: 332, 108, 338, 117 Destination: 105 Thumb: true Page: Label: D Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 134, 645, 148, 654 Destination: 105 Annotation: Subtype: Link Rect: 539, 502, 548, 512 Destination: 105 Thumb: true Page: Label: D Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 175, 251, 182, 260 Destination: 23 Annotation: Subtype: Link Rect: 273, 228, 280, 236 Destination: 42 Annotation: Subtype: Link Rect: 72, 108, 78, 116 Destination: 49 Annotation: Subtype: Link Rect: 208, 108, 219, 116 Destination: null Annotation: Subtype: Link Rect: 447, 501, 454, 509 Destination: 49 Annotation: Subtype: Link Rect: 328, 489, 339, 497 Destination: null Annotation: Subtype: Link Rect: 513, 388, 520, 396 Destination: 56 Annotation: Subtype: Link Rect: 536, 388, 543, 396 Destination: 67 Annotation: Subtype: Link Rect: 385, 244, 396, 252 Destination: null Annotation: Subtype: Link Rect: 536, 232, 543, 240 Destination: 77 Annotation: Subtype: Link Rect: 329, 172, 340, 181 Destination: null Annotation: Subtype: Link Rect: 358, 97, 365, 105 Destination: 90 Thumb: true Page: Label: D Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 79, 396, 84, 403 Destination: null Annotation: Subtype: Link Rect: 120, 385, 126, 394 Destination: null Annotation: Subtype: Link Rect: 516, 132, 535, 141 Destination: 105 Annotation: Subtype: Link Rect: 376, 72, 395, 81 Destination: 105 Thumb: true Page: Label: D Sequence: 6 Thumb: true Page: Label: D Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 107, 192, 116, 201 Destination: 105 Annotation: Subtype: Link Rect: 196, 132, 205, 141 Destination: 105 Annotation: Subtype: Link Rect: 540, 204, 550, 213 Destination: 105 Annotation: Subtype: Link Rect: 329, 96, 335, 105 Destination: 105 Thumb: true Page: Label: D Sequence: 8 Thumb: true Page: Label: D Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 127, 215, 148, 224 Destination: 105 Annotation: Subtype: Link Rect: 545, 156, 550, 165 Destination: 105 Annotation: Subtype: Link Rect: 531, 108, 539, 117 Destination: 105 Thumb: true Page: Label: D Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 341, 710, 347, 718 Destination: null Annotation: Subtype: Link Rect: 112, 555, 117, 563 Destination: null Annotation: Subtype: Link Rect: 152, 527, 156, 533 Destination: null Annotation: Subtype: Link Rect: 64, 517, 69, 525 Destination: null Annotation: Subtype: Link Rect: 138, 489, 143, 496 Destination: null Annotation: Subtype: Link Rect: 158, 326, 166, 335 Destination: 105 Annotation: Subtype: Link Rect: 97, 145, 106, 154 Destination: 105 Annotation: Subtype: Link Rect: 375, 219, 386, 227 Destination: null Thumb: true Page: Label: D Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 309, 508, 340, 517 Thumb: true Page: Label: D Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 124, 537, 146, 546 Annotation: Subtype: Link Rect: 144, 537, 255, 546 Annotation: Subtype: Link Rect: 58, 502, 79, 510 Annotation: Subtype: Link Rect: 77, 502, 165, 510 Annotation: Subtype: Link Rect: 234, 466, 256, 474 Annotation: Subtype: Link Rect: 254, 466, 285, 474 Annotation: Subtype: Link Rect: 58, 457, 148, 465 Annotation: Subtype: Link Rect: 218, 430, 240, 438 Annotation: Subtype: Link Rect: 238, 430, 285, 438 Annotation: Subtype: Link Rect: 58, 421, 109, 429 Annotation: Subtype: Link Rect: 234, 385, 256, 394 Annotation: Subtype: Link Rect: 254, 385, 285, 394 Annotation: Subtype: Link Rect: 58, 376, 129, 385 Annotation: Subtype: Link Rect: 123, 349, 145, 358 Annotation: Subtype: Link Rect: 143, 349, 240, 358 Annotation: Subtype: Link Rect: 128, 322, 150, 331 Annotation: Subtype: Link Rect: 148, 322, 243, 331 Annotation: Subtype: Link Rect: 189, 295, 211, 304 Annotation: Subtype: Link Rect: 209, 295, 285, 304 Annotation: Subtype: Link Rect: 58, 288, 81, 295 Annotation: Subtype: Link Rect: 120, 260, 141, 268 Annotation: Subtype: Link Rect: 139, 260, 215, 268 Annotation: Subtype: Link Rect: 517, 699, 539, 708 Annotation: Subtype: Link Rect: 537, 701, 548, 707 Annotation: Subtype: Link Rect: 320, 690, 456, 699 Annotation: Subtype: Link Rect: 481, 663, 502, 672 Annotation: Subtype: Link Rect: 500, 663, 548, 672 Annotation: Subtype: Link Rect: 320, 654, 372, 663 Annotation: Subtype: Link Rect: 481, 618, 502, 627 Annotation: Subtype: Link Rect: 500, 618, 548, 627 Annotation: Subtype: Link Rect: 320, 609, 368, 618 Annotation: Subtype: Link Rect: 320, 565, 342, 573 Annotation: Subtype: Link Rect: 340, 565, 433, 573 Annotation: Subtype: Link Rect: 320, 529, 342, 537 Annotation: Subtype: Link Rect: 340, 529, 437, 537 Annotation: Subtype: Link Rect: 458, 493, 479, 501 Annotation: Subtype: Link Rect: 478, 493, 548, 501 Annotation: Subtype: Link Rect: 320, 484, 363, 492 Annotation: Subtype: Link Rect: 381, 457, 403, 465 Annotation: Subtype: Link Rect: 401, 457, 503, 465 Annotation: Subtype: Link Rect: 506, 421, 528, 430 Annotation: Subtype: Link Rect: 526, 421, 548, 429 Annotation: Subtype: Link Rect: 320, 414, 407, 421 Annotation: Subtype: Link Rect: 481, 385, 502, 394 Annotation: Subtype: Link Rect: 500, 385, 548, 394 Annotation: Subtype: Link Rect: 320, 376, 373, 385 Annotation: Subtype: Link Rect: 382, 349, 403, 358 Annotation: Subtype: Link Rect: 401, 349, 502, 358 Annotation: Subtype: Link Rect: 461, 305, 482, 313 Annotation: Subtype: Link Rect: 480, 305, 548, 313 Annotation: Subtype: Link Rect: 320, 295, 374, 304 Annotation: Subtype: Link Rect: 481, 269, 502, 277 Annotation: Subtype: Link Rect: 500, 269, 548, 277 Annotation: Subtype: Link Rect: 320, 260, 376, 268 Thumb: true Checksum: b059fdd8 Type: CRC32 Checksum: 7080b8cbff66a728e887f9f68b5369dc Type: MD5 Checksum: f8a0725a562ec4e8751d20a8580f1180ef7733b9 Type: SHA-1 Checksum: ec1b2da8569340a8a0c9341c1f07091eaa190824175e81b30e8fa87ff289a9b5 Type: SHA-256