183a39fa9eafbface0daedd96d5d2858  41467_2024_Article_48339.pdf
bc3329d1428e9048a108dc738a07bc80262096da  41467_2024_Article_48339.pdf
cba79799923dd4217b1961d664eaaea856d23385f9b1e7137be472e958cd02ed  41467_2024_Article_48339.pdf

Title:           Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes
Subject:         Nature Communications, doi:10.1038/s41467-024-48339-5
Keywords:        
Author:          Junqing Xie
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Mon May 13 14:38:18 2024 CEST
ModDate:         Mon May 13 16:30:27 2024 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2244903 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EPKPHH+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no      81  0
EPKPHI+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes    219  0
EPKPLI+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      34  0
EPKNBA+AdvOT13119950                 Type 1C           WinAnsi          yes yes no      42  0
EPKNBB+AdvOT89719618                 Type 1C           WinAnsi          yes yes no      43  0
EPKNCC+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no     522  0
EPKPDG+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no      44  0
EPKPDH+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes     45  0
EPKPEI+AdvOTdd63dae3+20              Type 1C           WinAnsi          yes yes no      46  0
EPKPNI+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no      32  0
EPKPNJ+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no      33  0
EPLANK+AdvOT3d287b35.B+fb            Type 1C           Custom           yes yes yes     35  0
CourierNewPSMT                       Type 1C           WinAnsi          yes no  no      36  0
EPLAMK+Helvetica                     Type 1C           WinAnsi          yes yes no      37  0
EPKPNM+AdvOTdd63dae3+22              Type 1C           Custom           yes yes yes     38  0
EPLAHJ+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      39  0
EPKPNK+AdvOT70e1938e+fb              Type 1C           Custom           yes yes yes     40  0
EPKPNL+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      41  0
EPLBAM+AdvOT0c200bf0+20              Type 1C           Custom           yes yes yes     80  0
EPLBAN+AdvOT0c200bf0+22              Type 1C           Custom           yes yes yes     82  0
EPLBAL+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no      83  0
EPLAPK+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes     84  0
EPLMBK+AdvOT8608a8d1+22              Type 1C           Custom           yes yes yes    220  0
EPLMEK+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     240  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-03-19 02:41:53 CET
 RepresentationInformation: 41467_2024_Article_48339.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-03-18 19:04:00 CET
  Size: 2244903
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 647
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Verification and extension of previous key findings
          Destination: B1
         Item: 
          Title: Discovery and validation of novel HLA allele associations with antibody response
          Destination: B2
         Item: 
          Title: Extrapolation of HLA effects on COVID-19 breakthrough outcomes
          Destination: B3
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Study design and participants
          Destination: B4
         Item: 
          Title: UK Biobank’study
          Destination: B5
         Item: 
          Title: Self-test SARS-CoV-2 coronavirus antibody’study
          Destination: B6
         Item: 
          Title: SARS-CoV-2 coronavirus infection’study
          Destination: B7
         Item: 
          Title: Secondary data linkage
          Destination: B8
         Item: 
          Title: Analytic cohorts
          Destination: B9
         Item: 
          Title: Genotyping and HLA imputation
          Destination: B10
         Item: 
          Title: Ascertainment of antibody-positive and COVID-19 outcomes
          Destination: B11
         Item: 
          Title: Statistical analyses
          Destination: B12
         Item: 
          Title: Characterisation of vaccinated cohorts
          Destination: B13
         Item: 
          Title: Genome-wide association analysis
          Destination: B14
         Item: 
          Title: HLA gene-based association analysis
          Destination: B15
         Item: 
          Title: Genetic’score
          Destination: B16
         Item: 
          Title: Drug/vaccine-target Mendelian randomisation analysis
          Destination: B17
         Item: 
          Title: Reporting summary
          Destination: B18
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: Code availability
        Destination: M2
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes
    Author: Junqing Xie
    Subject: Nature Communications, doi:10.1038/s41467-024-48339-5
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Mon May 13 15:08:18 CEST 2024
    ModDate: Mon May 13 16:30:27 CEST 2024
   ID: 0xf1a36631d6a2722339c5a302d5ce5579, 0xec653cde07ab7123f4b64de52d5d7aab
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1404
      ImageHeight: 521
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1356
      ImageHeight: 1848
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1789
      ImageHeight: 586
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EPKPNI+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 42
      LastChar: 124
      FontDescriptor: 
       FontName: EPKPNI+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPNJ+AdvOT70e1938e
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: EPKPNJ+AdvOT70e1938e
       Flags: Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPLI+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: EPKPLI+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPLANK+AdvOT3d287b35.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EPLANK+AdvOT3d287b35.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 875, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CourierNewPSMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CourierNewPSMT
       Flags: Nonsymbolic
       FontBBox: -122, -680, 623, 1021
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPLAMK+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: EPLAMK+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPNM+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: EPKPNM+AdvOTdd63dae3+22
       Flags: Symbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPLAHJ+Helvetica-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: EPLAHJ+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPNK+AdvOT70e1938e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EPKPNK+AdvOT70e1938e+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPKPNL+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 80
      LastChar: 121
      FontDescriptor: 
       FontName: EPKPNL+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKNBA+AdvOT13119950
      FontSubset: true
      FirstChar: 37
      LastChar: 246
      FontDescriptor: 
       FontName: EPKNBA+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKNCC+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: EPKNCC+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKNBB+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: EPKNBB+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPDG+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 37
      LastChar: 239
      FontDescriptor: 
       FontName: EPKPDG+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPDH+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EPKPDH+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPKPEI+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: EPKPEI+AdvOTdd63dae3+20
       Flags: Nonsymbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPLBAM+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 2
      LastChar: 150
      FontDescriptor: 
       FontName: EPLBAM+AdvOT0c200bf0+20
       Flags: Symbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPLMEK+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EPLMEK+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPKPHH+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 37
      LastChar: 233
      FontDescriptor: 
       FontName: EPKPHH+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPLBAN+AdvOT0c200bf0+22
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: EPLBAN+AdvOT0c200bf0+22
       Flags: Symbolic
       FontBBox: -10, -250, 645, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPLBAL+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EPLBAL+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EPLAPK+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EPLAPK+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPKPHI+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EPKPHI+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPLMBK+AdvOT8608a8d1+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EPLMBK+AdvOT8608a8d1+22
       Flags: Symbolic
       FontBBox: 0, -322, 1218, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-024-48339-5</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Junqing Xie</rdf:li>
               <rdf:li>Beatriz Mothe</rdf:li>
               <rdf:li>Marta Alcalde Herraiz</rdf:li>
               <rdf:li>Chunxiao Li</rdf:li>
               <rdf:li>Yu Xu</rdf:li>
               <rdf:li>Annika M. Jödicke</rdf:li>
               <rdf:li>Yaqing Gao</rdf:li>
               <rdf:li>Yunhe Wang</rdf:li>
               <rdf:li>Shuo Feng</rdf:li>
               <rdf:li>Jia Wei</rdf:li>
               <rdf:li>Zhuoyao Chen</rdf:li>
               <rdf:li>Shenda Hong</rdf:li>
               <rdf:li>Yeda Wu</rdf:li>
               <rdf:li>Binbin Su</rdf:li>
               <rdf:li>Xiaoying Zheng</rdf:li>
               <rdf:li>Catherine Cohet</rdf:li>
               <rdf:li>Raghib Ali</rdf:li>
               <rdf:li>Nick Wareham</rdf:li>
               <rdf:li>Daniel Prieto Alhambra</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-024-48339-5</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-05-13T16:30:27+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2024-05-13T18:08:18+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-05-13T16:30:27+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:e37e3e6c-c61f-4aef-b5c3-85e444e78f0e</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:65e41b4b-d29c-4b25-b835-29b59c04caef</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:de7cfe55-b26b-4db2-ac33-c004cf6dccf9</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-05-13T18:09:26+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 267, 520, 268, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 520, 268, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 276, 519, 277, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 519, 276, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 276, 519, 277, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 520, 346, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 520, 346, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 519, 354, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 519, 353, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 519, 354, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 242, 507, 244, 517
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 242, 507, 244, 517
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 506, 252, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 242, 506, 251, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 506, 253, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 507, 527, 517
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 507, 527, 517
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 506, 536, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 506, 535, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 506, 536, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 495, 248, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 495, 248, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 256, 493, 257, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 493, 256, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 256, 493, 257, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 495, 330, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 495, 330, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 338, 493, 338, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 329, 493, 338, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 338, 493, 339, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 495, 411, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 495, 411, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 418, 493, 419, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 410, 493, 418, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 418, 493, 420, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 477, 495, 478, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 477, 495, 478, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 493, 487, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 477, 493, 486, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 493, 487, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 375, 482, 376, 491
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 375, 482, 376, 491
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 384, 480, 385, 490
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 375, 480, 384, 490
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 384, 480, 385, 490
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 469, 281, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 469, 281, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 468, 289, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 280, 468, 288, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 468, 290, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 469, 415, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 469, 415, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 422, 468, 423, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 468, 422, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 422, 468, 423, 477
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 238, 95, 240, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 135, 84, 138, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 139, 84, 142, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 419, 127, 422, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 425, 127, 428, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: -2, 447, 50, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 455, 50, 486
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 458, 40, 468
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 458, 40, 468
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 48, 402, 55
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 245, 726, 248, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 251, 726, 254, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 195, 705, 200, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 137, 694, 141, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 80, 598, 85, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 87, 598, 91, 603
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 103, 512, 108, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 331, 722, 334, 730
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 451, 636, 454, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 60
      Annotation: 
       Subtype: Link
       Rect: 368, 401, 372, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 294, 85, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 187, 165, 191, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 146, 133, 151, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 84, 69, 88, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 471, 272, 475, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 418, 165, 423, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 551, 165, 555, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 347, 90, 351, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 79, 128, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 325, 90, 329, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 169, 101, 174, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 321, 272, 326, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 404, 187, 409, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 443, 101, 447, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 115
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 339, 105, 343, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 344, 105, 348, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 430, 62, 435, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 694, 260, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 86, 684, 91, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 201, 684, 206, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 286, 609, 292, 613
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 288, 394, 292, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 243, 362, 247, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 250, 341, 255, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 67, 212, 71, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 261, 191, 266, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 268, 191, 273, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 219, 116, 224, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 226, 116, 231, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 399, 694, 404, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 508, 512, 513, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 737, 113, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 163, 701, 267, 709
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 283, 294, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 272, 223, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 444, 716, 450, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 427, 684, 432, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 433, 684, 438, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 484, 191, 489, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 404, 116, 409, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 452, 101, 561, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 90, 453, 98
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 705, 144, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 106, 212, 111, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 448, 684, 454, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 205
      Annotation: 
       Subtype: Link
       Rect: 474, 133, 561, 141
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 122, 359, 131
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 58, 561, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 47, 377, 56
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 711, 267, 719
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 701, 101, 709
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 138, 508, 257, 516
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 497, 89, 505
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 112, 173, 120
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 476, 200, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 677, 421, 685
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 505, 561, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 495, 365, 502
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 408, 280, 545, 287
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: ada108c5
   Type: CRC32
  Checksum: 183a39fa9eafbface0daedd96d5d2858
   Type: MD5
  Checksum: bc3329d1428e9048a108dc738a07bc80262096da
   Type: SHA-1
  Checksum: cba79799923dd4217b1961d664eaaea856d23385f9b1e7137be472e958cd02ed
   Type: SHA-256