b230e3068b37617aaf7f7f92c3aa4313 309333.pdf aef1e0521f82a5705072f975d0490fe8adeab106 309333.pdf f7a114967b6eac4ca0e8a204cc6f9421a37374bb36aa6464b341422f7cae1629 309333.pdf Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Oct 23 08:04:26 2024 CEST ModDate: Tue Oct 29 01:28:14 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2356704 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Light Type 1C Custom yes no yes 38 0 MyriadPro-Regular Type 1C Custom yes no yes 35 0 MyriadPro-Semibold Type 1C WinAnsi yes no yes 39 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 37 0 MyriadPro-It Type 1C WinAnsi yes no yes 1911 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 90 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 1965 0 WarnockPro-Regular Type 1C Custom yes no yes 36 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 42 0 MyriadPro-It Type 1C WinAnsi yes no yes 45 0 SymbolStd Type 1C WinAnsi yes no yes 66 0 WarnockPro-It Type 1C WinAnsi yes no yes 67 0 MyriadPro-SemiboldIt Type 1C Custom yes no yes 68 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 204 0 MyriadPro-It Type 1C WinAnsi yes no yes 193 0 ZYBIGA+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 79 0 WarnockPro-Bold Type 1C WinAnsi yes no yes 80 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-24 02:40:32 CEST RepresentationInformation: 309333.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-23 14:00:52 CEST Size: 2356704 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2009 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Development and validation of the post-CAR prognostic index for large B-cell lymphoma patients after CAR-T progression in third or later line treatment Children: Item: Title: Abstract Item: Title: Key points Item: Title: Introduction Item: Title: Methods Children: Item: Title: Patients Item: Title: Endpoints and study plan Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Training cohort Children: Item: Title: Patient characteristics Item: Title: Outcomes after disease progression to CAR T-cells Item: Title: Development of the Post-CAR Prognostic Index Children: Item: Title: Variable selection and defined prognostic subgroups Item: Title: Performance of the Post-CAR Prognostic Index Children: Item: Title: Validation cohort Children: Item: Title: Patient characteristics of the validation cohort Item: Title: Post-CAR Prognostic Index in the validation cohort Item: Title: Comparison of the Post-CAR Prognostic Index with the IPI and R-IPI scores Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Oct 23 08:04:26 CEST 2024 ModDate: Tue Oct 29 01:28:14 CET 2024 ID: 0x3a0c11bca21b98c69e0581d87dde6067, 0xd0e49dd1c9b45044ebe13e69aa62e59c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1677 ImageHeight: 1182 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 1561 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 1393 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric ImageMask: true Decode: 0, 1 Name: X Fonts: Type1: Font: BaseFont: WarnockPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Bold Flags: Serif, Nonsymbolic FontBBox: -183, -599, 1614, 1030 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SymbolStd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SymbolStd Flags: Nonsymbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -222, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -175, -250, 1007, 933 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: ZYBIGA+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: ZYBIGA+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: uuid:a411d6aa-9084-4147-bb2f-cd26bfe5675d adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31 xmp.id:05788e8e-f0fb-6d4c-8280-c34a33081a8b proof:pdf 1 xmp.iid:d6fda58b-bf9d-f14c-9acd-372f96cad439 xmp.did:d93769b6-457f-8247-aece-3843474f5b3a default converted from application/x-indesign to application/pdf Adobe InDesign 18.0 (Windows) 2024-10-23T08:04:26+02:00 converted uuid:97e9aeb5-e2fe-4153-ad05-225b6584bf99 converted to PDF/A-2b pdfToolbox 2024-10-27T11:25:11+01:00 2024-10-23T08:04:26+02:00 2024-10-29T01:28:14+01:00 2024-10-29T01:28:14+01:00 Adobe InDesign 18.0 (Windows) journal 10.1186/s13045-024-01608-8 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1186/s13045-024-01608-8 springer.com springerlink.com VoR application/pdf Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef internal An unordered array of references to resources that were incorporated, by inclusion or reference, into this document. Ingredients Bag ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 522, 73, 538, 65 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 65, 293, 57 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 682, 540, 649 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 127, 527, 132, 514 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 138, 527, 148, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 259, 491, 269, 478 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 275, 491, 285, 478 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 205, 455, 214, 442 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 220, 455, 230, 442 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 167, 395, 176, 382 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 173, 371, 183, 358 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 122, 335, 132, 322 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 139, 299, 149, 286 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 155, 299, 165, 286 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 211, 287, 221, 274 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 227, 287, 237, 274 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 458, 443, 468, 430 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 472, 443, 482, 430 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 487, 443, 497, 430 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 340, 419, 345, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 351, 419, 356, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 363, 419, 373, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 380, 419, 390, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 397, 419, 406, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 413, 419, 423, 406 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 353, 143, 363, 130 Flags: Print AppearanceDictionary: true Destination: 142 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 59, 683, 69, 670 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 259, 527, 269, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 277, 527, 287, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 132, 263, 142, 250 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 147, 263, 157, 250 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 165, 251, 175, 238 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 119, 215, 129, 202 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 275, 155, 285, 142 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 199, 131, 209, 118 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 414, 599, 419, 586 Flags: Print AppearanceDictionary: true Destination: 70 Annotation: Subtype: Link Rect: 443, 515, 448, 502 Flags: Print AppearanceDictionary: true Destination: 85 Annotation: Subtype: Link Rect: 335, 191, 340, 178 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 360, 83, 365, 70 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 79, 311, 84, 298 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 115, 287, 120, 274 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 478, 263, 483, 250 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 495, 227, 499, 214 Flags: Print AppearanceDictionary: true Destination: 91 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 325, 647, 330, 634 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 499, 611, 504, 598 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 325, 563, 330, 550 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 391, 491, 395, 478 Flags: Print AppearanceDictionary: true Destination: 101 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 398, 299, 408, 286 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 414, 299, 424, 286 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 523, 119, 533, 106 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 347, 71, 357, 58 Flags: Print AppearanceDictionary: true Destination: 142 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 132, 635, 142, 622 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 146, 635, 156, 622 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 161, 635, 171, 622 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 176, 635, 185, 622 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 159, 563, 168, 550 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 174, 563, 184, 550 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 184, 527, 194, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 199, 527, 209, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 214, 527, 224, 514 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 59, 503, 69, 490 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 278, 479, 288, 466 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 56, 467, 66, 454 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 71, 467, 81, 454 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 87, 467, 96, 454 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 102, 467, 112, 454 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 328, 287, 338, 274 Flags: Print AppearanceDictionary: true Destination: 142 Annotation: Subtype: Link Rect: 343, 287, 353, 274 Flags: Print AppearanceDictionary: true Destination: 142 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 248, 695, 281, 686 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 686, 156, 677 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 340, 684, 537, 675 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 675, 364, 666 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 468, 497, 459 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 432, 498, 423 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 9582ea84 Type: CRC32 Checksum: b230e3068b37617aaf7f7f92c3aa4313 Type: MD5 Checksum: aef1e0521f82a5705072f975d0490fe8adeab106 Type: SHA-1 Checksum: f7a114967b6eac4ca0e8a204cc6f9421a37374bb36aa6464b341422f7cae1629 Type: SHA-256