693ded5ff0eb3021935545c58537443e  309343.pdf
e8556ab698ca774a5c21a202796e4078b3d18a2d  309343.pdf
5ef82ac273496c23656130d3b1a814d5101ffb31ced745683907890edf8b2f45  309343.pdf

Title:           Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts
Subject:         Nature Communications, doi:10.1038/s41467-024-53163-y
Keywords:        
Author:          Umberto Perron
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Oct 17 00:44:11 2024 CEST
ModDate:         Wed Oct 23 15:39:34 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           20
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2549195 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
JAHOGL+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     874  0
JAHOHM+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes    875  0
JAHOOK+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      99  0
JAHKBP+AdvOT13119950                 Type 1C           WinAnsi          yes yes no     100  0
JAHKCA+AdvOT89719618                 Type 1C           WinAnsi          yes yes no     101  0
JAHKDB+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no    1341  0
JAHNPL+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no     102  0
JAHNPM+AdvOTdd63dae3+20              Type 1C           WinAnsi          yes yes no     104  0
JAHNPN+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes    106  0
JAHPBK+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      97  0
JAHPBL+AdvOTdd63dae3+22              Type 1C           Custom           yes yes yes     98  0
JAHPCL+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no     103  0
JAHPDM+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no     105  0
HelveticaNeue-Bold                   Type 1C           WinAnsi          yes no  no     114  0
ArialMT                              Type 1C           WinAnsi          yes no  no     115  0
JAIIDI+AdvOT70e1938e+fb              Type 1C           Custom           yes yes yes    159  0
JAIJHB+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes    315  0
JAJIHG+AdvOT3d287b35.B+fb            Type 1C           Custom           yes yes yes    384  0
JAJMFA+AdvOTcc1f6510.I+20            Type 1C           WinAnsi          yes yes no     636  0
JAJMIA+AdvP4C4E59                    Type 1C           WinAnsi          yes yes no     663  0
JAJMIB+AdvP4C4E46                    Type 1C           WinAnsi          yes yes no     664  0
JAJMHP+AdvMacMthSyN                  Type 1C           Custom           yes yes yes    665  0
JAJMIC+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     666  0
JAJNEA+AdvOT0c200bf0+20              Type 1C           WinAnsi          yes yes no     876  0
JAJNCP+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no     877  0
JAJNIA+AdvOT0c200bf0+03              Type 1C           Custom           yes yes yes    886  0
JAJNHA+AdvOT23e3f5cb.I+20            Type 1C           WinAnsi          yes yes no     887  0
JAJNPO+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     931  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-04-24 02:40:23 CEST
 RepresentationInformation: 309343.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-04-23 14:00:30 CEST
  Size: 2549195
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1494
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Multi-omic characterisation of the IRCC-PDX collection
          Destination: B1
         Item: 
          Title: Exploratory single-omic analysis of the IRCC-PDX collection
          Destination: B2
         Item: 
          Title: Confirmation of established biomarkers of cetuximab sensitivity
          Destination: B3
         Item: 
          Title: A stacked classifier modelling cetuximab sensitivity
          Destination: B4
         Item: 
          Title: Candidate biomarkers of cetuximab sensitivity
          Destination: B5
         Item: 
          Title: Validation of the CeSta classifier
          Destination: B6
         Item: 
          Title: Explanation of the CeSta classifier
          Destination: B7
         Item: 
          Title: Comparison of cetuximab response in cell lines and PDX models
          Destination: B8
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Ethics statement
          Destination: B9
         Item: 
          Title: Genomic data collection
          Destination: B10
         Item: 
          Title: TCGA COAD/READ copy number calling
          Destination: B11
         Item: 
          Title: Comparing driver gene SNPs in TCGA COAD/READ and PDXs
          Destination: B12
         Item: 
          Title: Comparing copy number variation events in TCGA COAD/READ and PDXs
          Destination: B13
         Item: 
          Title: Assessing PDX copy number stability within lineages
          Destination: B14
         Item: 
          Title: Assessing PDX mutational stability within lineages
          Destination: B15
         Item: 
          Title: Gene expression data collection and differential expression analysis
          Destination: B16
         Item: 
          Title: Methylation data collection
          Destination: B17
         Item: 
          Title: Clinical data collection
          Destination: B18
         Item: 
          Title: Measuring cetuximab response in PDX models
          Destination: B19
         Item: 
          Title: Genomic feature engineering
          Destination: B20
         Item: 
          Title: Transcriptomic feature engineering
          Destination: B21
         Item: 
          Title: Clinical feature engineering
          Destination: B22
         Item: 
          Title: Single-omic exploration of IRCC-PDX data
          Destination: B23
         Item: 
          Title: Model architecture
          Destination: B24
         Item: 
          Title: Model training, tuning, and validation
          Destination: B25
         Item: 
          Title: Performance baselines
          Destination: B26
         Item: 
          Title: Cell line multiomic data source
          Destination: B27
         Item: 
          Title: External validation: Charles River dataset
          Destination: B28
         Item: 
          Title: Post-hoc model explanation
          Destination: B29
         Item: 
          Title: Reporting summary
          Destination: B30
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: Code availability
        Destination: M2
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts
    Author: Umberto Perron
    Subject: Nature Communications, doi:10.1038/s41467-024-53163-y
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Oct 17 01:14:11 CEST 2024
    ModDate: Wed Oct 23 15:39:34 CEST 2024
   ID: 0xb032b30ee094280d39819cc78f0afa9c, 0xe941aabcadcc33317af040bf857b435d
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1754
      ImageHeight: 1267
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1121
      ImageHeight: 23
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1750
      ImageHeight: 1892
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 20
      ImageHeight: 849
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: JAJIHG+AdvOT3d287b35.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JAJIHG+AdvOT3d287b35.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 875, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAJMIA+AdvP4C4E59
      FontSubset: true
      FirstChar: 58
      LastChar: 58
      FontDescriptor: 
       FontName: JAJMIA+AdvP4C4E59
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAJMIB+AdvP4C4E46
      FontSubset: true
      FirstChar: 83
      LastChar: 83
      FontDescriptor: 
       FontName: JAJMIB+AdvP4C4E46
       Flags: Nonsymbolic
       FontBBox: 55, -1000, 776, 0
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAJMHP+AdvMacMthSyN
      FontSubset: true
      FirstChar: 1
      LastChar: 110
      FontDescriptor: 
       FontName: JAJMHP+AdvMacMthSyN
       Flags: Symbolic
       FontBBox: 0, -947, 1239, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAJMIC+AdvP4C4E51
      FontSubset: true
      FirstChar: 58
      LastChar: 58
      FontDescriptor: 
       FontName: JAJMIC+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAIIDI+AdvOT70e1938e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JAIIDI+AdvOT70e1938e+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAHPBK+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 38
      LastChar: 121
      FontDescriptor: 
       FontName: JAHPBK+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHPBL+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: JAHPBL+AdvOTdd63dae3+22
       Flags: Symbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAHOOK+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: JAHOOK+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAJNPO+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: JAJNPO+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHKBP+AdvOT13119950
      FontSubset: true
      FirstChar: 38
      LastChar: 122
      FontDescriptor: 
       FontName: JAHKBP+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHKCA+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: JAHKCA+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHNPL+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 35
      LastChar: 224
      FontDescriptor: 
       FontName: JAHNPL+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHPCL+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 45
      LastChar: 124
      FontDescriptor: 
       FontName: JAHPCL+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHNPM+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: JAHNPM+AdvOTdd63dae3+20
       Flags: Nonsymbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHPDM+AdvOT70e1938e
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: JAHPDM+AdvOT70e1938e
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHNPN+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JAHNPN+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAHOGL+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: JAHOGL+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHOHM+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: JAHOHM+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAJNEA+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: JAJNEA+AdvOT0c200bf0+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAJNCP+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 38
      LastChar: 121
      FontDescriptor: 
       FontName: JAJNCP+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HelveticaNeue-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeue-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAJNIA+AdvOT0c200bf0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JAJNIA+AdvOT0c200bf0+03
       Flags: Symbolic
       FontBBox: -156, -177, 802, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAJNHA+AdvOT23e3f5cb.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: JAJNHA+AdvOT23e3f5cb.I+20
       Flags: Nonsymbolic
       FontBBox: -260, -104, 1062, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAIJHB+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: JAIJHB+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JAJMFA+AdvOTcc1f6510.I+20
      FontSubset: true
      FirstChar: 145
      LastChar: 146
      FontDescriptor: 
       FontName: JAJMFA+AdvOTcc1f6510.I+20
       Flags: Nonsymbolic
       FontBBox: -250, -125, 1291, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: JAHKDB+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: JAHKDB+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-024-53163-y</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer patient-derived xenografts</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Umberto Perron</rdf:li>
               <rdf:li>Elena Grassi</rdf:li>
               <rdf:li>Aikaterini Chatzipli</rdf:li>
               <rdf:li>Marco Viviani</rdf:li>
               <rdf:li>Emre Karakoc</rdf:li>
               <rdf:li>Lucia Trastulla</rdf:li>
               <rdf:li>Lorenzo M. Brochier</rdf:li>
               <rdf:li>Claudio Isella</rdf:li>
               <rdf:li>Eugenia R. Zanella</rdf:li>
               <rdf:li>Hagen Klett</rdf:li>
               <rdf:li>Ivan Molineris</rdf:li>
               <rdf:li>Julia Schueler</rdf:li>
               <rdf:li>Manel Esteller</rdf:li>
               <rdf:li>Enzo Medico</rdf:li>
               <rdf:li>Nathalie Conte</rdf:li>
               <rdf:li>Ultan McDermott</rdf:li>
               <rdf:li>Livio Trusolino</rdf:li>
               <rdf:li>Andrea Bertotti</rdf:li>
               <rdf:li>Francesco Iorio</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-024-53163-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41467-024-53163-y</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41467-024-53163-y</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:copyright>© 2024, The Author(s)</prism:copyright>
         <prism:issn>2041-1723</prism:issn>
         <pdfx:doi>10.1038/s41467-024-53163-y</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41467-024-53163-y</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-10-23T15:39:34+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2024-10-17T04:14:11+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2024-10-23T15:39:34+02:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords></pdf:Keywords>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:d95d865d-b0a2-4bd1-9225-d4a3be491344</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:363d35c6-c653-4a0b-9906-a616b6f036c1</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:1494afec-3fb0-48aa-9abd-14c16791ba14</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-10-17T04:15:11+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Elena Grassi</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1066-927X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Marco Viviani</author:name>
                  <author:orcid>http://orcid.org/0000-0003-4698-8870</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Lorenzo M. Brochier</author:name>
                  <author:orcid>http://orcid.org/0009-0002-5306-094X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Claudio Isella</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0679-4756</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ivan Molineris</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2102-0804</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Julia Schueler</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1984-7343</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Manel Esteller</author:name>
                  <author:orcid>http://orcid.org/0000-0003-4490-6093</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Enzo Medico</author:name>
                  <author:orcid>http://orcid.org/0000-0002-3917-2438</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ultan McDermott</author:name>
                  <author:orcid>http://orcid.org/0000-0001-9032-4700</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Livio Trusolino</author:name>
                  <author:orcid>http://orcid.org/0000-0002-6379-3365</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Andrea Bertotti</author:name>
                  <author:orcid>http://orcid.org/0000-0001-8196-7608</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Francesco Iorio</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7063-8913</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 363, 552, 364, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 363, 552, 364, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 372, 550, 373, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 363, 550, 372, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 372, 550, 373, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 539, 276, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 539, 276, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 284, 538, 285, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 538, 284, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 284, 538, 285, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 539, 532, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 539, 532, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 538, 541, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 538, 540, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 538, 541, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 527, 277, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 527, 277, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 284, 525, 285, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 275, 525, 284, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 284, 525, 285, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 527, 510, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 527, 510, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 517, 525, 518, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 525, 517, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 517, 525, 519, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 277, 514, 278, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 277, 514, 278, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 512, 287, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 277, 512, 286, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 512, 287, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 514, 359, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 514, 359, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 512, 367, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 358, 512, 366, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 512, 368, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 514, 460, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 514, 460, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 512, 469, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 512, 468, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 512, 469, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 291, 501, 292, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 291, 501, 292, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 500, 301, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 291, 500, 300, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 500, 301, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 501, 383, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 501, 383, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 500, 391, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 500, 390, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 500, 392, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 491, 501, 493, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 491, 501, 493, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 500, 501, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 492, 500, 500, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 500, 502, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 283, 488, 284, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 283, 488, 284, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 487, 293, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 283, 487, 292, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 487, 293, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 234, 159, 236, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 227, 137, 230, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 232, 137, 235, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 202, 127, 205, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 207, 127, 210, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 212, 95, 215, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 437, 148, 439, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 538, 127, 541, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: -2, 479, 50, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 486, 50, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 48, 336, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 48, 416, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 420, 48, 499, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 716, 278, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 280, 716, 285, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 288, 716, 292, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 89, 684, 92, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 93, 684, 98, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 100, 684, 104, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 78, 651, 83, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 84, 651, 89, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 196, 619, 201, 624
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 202, 619, 207, 624
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 115, 534, 117, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 119, 534, 121, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 122, 534, 128, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 131, 534, 136, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 259, 501, 265, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 266, 501, 272, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 271, 491, 277, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 88, 448, 94, 453
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 268, 352, 273, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 143, 298, 148, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 325, 679, 328, 687
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 494, 572, 498, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 405, 512, 407, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 360, 486, 364, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 324, 476, 327, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 342, 459, 347, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 542, 448, 547, 453
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 386, 437, 392, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 343, 416, 348, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 337, 330, 339, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 341, 330, 343, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 345, 330, 350, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 352, 330, 356, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 357, 330, 363, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 364, 330, 369, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 506, 294, 509, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 437, 262, 542, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 356, 255, 362, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 368, 251, 499, 259
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 450, 180, 455, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 403, 105, 408, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 410, 105, 415, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 523, 139, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 265, 501, 271, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 272, 501, 278, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 57, 491, 59, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 57, 465, 61, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 115, 437, 120, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 277, 373, 282, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 224, 298, 230, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 289, 212, 294, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 80, 191, 85, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 372, 105, 374, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 337, 62, 342, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 467, 594, 561, 601
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 584, 400, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 352, 208, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 210, 352, 215, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 254, 352, 257, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 148, 341, 153, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 154, 341, 160, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 206, 283, 210, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 137, 187, 142, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 417, 298, 423, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 535, 223, 541, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 480, 137, 486, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 209, 406, 213, 413
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 694, 139, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 69, 662, 73, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 236, 658, 239, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 281, 587, 286, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 287, 587, 292, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 117, 555, 122, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 210, 508, 214, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 202, 465, 205, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 90, 422, 93, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 176, 401, 179, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 209, 330, 214, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 177, 283, 180, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 86, 212, 92, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 149, 208, 152, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 145, 197, 149, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 283, 144, 287, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 409, 459, 415, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 416, 459, 421, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 445, 422, 449, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 420, 352, 425, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 555, 341, 561, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 488, 330, 493, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 480, 287, 486, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 352, 244, 357, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 358, 244, 363, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 362, 212, 367, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 370, 212, 375, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 452, 202, 458, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 493, 148, 498, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 500, 148, 505, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 242, 651, 247, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 225, 636, 229, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 205, 583, 209, 591
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 81, 572, 85, 580
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 77, 480, 83, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 121, 433, 125, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 227, 412, 231, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 101, 362, 107, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 109, 362, 114, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 184, 352, 190, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 209, 304, 214, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 102, 283, 106, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 57, 219, 61, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 242, 187, 246, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 188, 137, 194, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 196, 137, 201, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 189, 101, 192, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 534, 647, 539, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 463, 594, 468, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 508, 352, 513, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 553, 191, 558, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 385, 101, 389, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 342, 90, 347, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 383, 69, 388, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 47, 165, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 509, 62, 514, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 208, 166, 213, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 214, 166, 219, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 472, 52, 477, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 716, 128, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 129, 716, 134, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 136, 716, 141, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 131, 705, 135, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 137, 705, 142, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 278, 673, 283, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 204, 641, 209, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 264, 587, 269, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 289, 512, 294, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 58, 486, 62, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 150, 304, 155, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 123, 283, 128, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 57, 240, 61, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 108, 159, 113, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 360, 576, 366, 581
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 522, 544, 528, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 482, 523, 487, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 342, 491, 348, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 368, 298, 373, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 388, 255, 393, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 469, 193, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 73, 444, 171, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 287, 137, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 84, 240, 226, 248
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 229, 196, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 143, 219, 253, 227
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 360, 705, 365, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 366, 705, 372, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 539, 684, 545, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 350, 673, 355, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 411, 609, 416, 613
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 426, 604, 558, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 379, 583, 493, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 519, 561, 527
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 508, 360, 516
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 524, 512, 529, 517
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 343, 469, 349, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 382, 394, 387, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 342, 330, 348, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 556, 330, 561, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 308, 315, 436, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 283, 561, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 272, 499, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 229, 561, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 219, 434, 227
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 187, 561, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 176, 374, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 364, 73, 369, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 471, 69, 561, 77
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 58, 466, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 555, 62, 560, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 308, 47, 436, 56
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 119, 658, 294, 666
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 647, 163, 655
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 267, 176, 294, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 165, 190, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 179, 116, 184, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 483, 716, 489, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 523, 705, 529, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 383, 658, 561, 666
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 647, 322, 655
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 534, 534, 537, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 514, 501, 519, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 495, 437, 501, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 375, 427, 380, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 375, 384, 380, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 395, 373, 397, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 441, 352, 447, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 374, 319, 380, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 440, 287, 446, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 447, 287, 456, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 517, 287, 524, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 336, 277, 342, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 435, 272, 561, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 262, 398, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 349, 240, 561, 248
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 229, 361, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 169, 469, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 487, 159, 495, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 438, 112, 561, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 101, 361, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 101, 561, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 90, 481, 98
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 69, 535, 77
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 269, 658, 294, 666
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 647, 238, 655
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 288, 630, 292, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 42, 615, 281, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 604, 269, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 437, 278, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 97, 352, 102, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 193, 341, 201, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 261, 341, 268, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 200, 298, 208, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 190, 283, 294, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 272, 151, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 87, 176, 263, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 453, 501, 455, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 457, 501, 463, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 541, 437, 543, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 356, 298, 359, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 360, 298, 366, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 342, 287, 349, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 462, 277, 470, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 355, 95, 360, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 444, 52, 452, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 450, 726, 456, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 462, 722, 561, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 711, 377, 720
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 339, 694, 345, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 344, 684, 349, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 487, 330, 492, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 429, 315, 558, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 309, 447, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 844
      Annotation: 
       Subtype: Link
       Rect: 489, 304, 561, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 294, 445, 302
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 94, 716, 101, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 103, 716, 109, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 120, 647, 123, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 263, 630, 270, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 272, 630, 277, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 170, 551, 173, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 193, 540, 197, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 199, 508, 203, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 261, 497, 264, 505
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 56, 427, 61, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 275, 244, 282, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 251, 144, 254, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 196, 127, 202, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 324, 615, 327, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 399, 540, 403, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 500, 437, 506, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 459, 277, 466, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 316, 197, 441, 206
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 187, 561, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 176, 331, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 90, 510, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 157, 726, 162, 731
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 168, 722, 294, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 711, 61, 720
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 162, 690, 294, 698
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 679, 163, 687
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 433, 173, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 166, 352, 172, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 179, 347, 294, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 337, 286, 345
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 326, 290, 334
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 315, 171, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 222, 154, 294, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 144, 96, 152
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 339, 684, 345, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 377, 572, 444, 580
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 561, 377, 570
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 450, 465, 489, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 336, 444, 365, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 433, 343, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 351, 433, 355, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 421, 433, 561, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 422, 347, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 431, 412, 436, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 440, 412, 445, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 499, 412, 561, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 401, 387, 409
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 449, 379, 561, 388
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 369, 547, 377
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 358, 549, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 347, 436, 355
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 318, 326, 561, 334
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 315, 561, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 304, 561, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 294, 561, 302
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 283, 561, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 272, 556, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 262, 561, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 251, 379, 259
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 229, 507, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 234, 513, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 392, 212, 397, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 878
      Annotation: 
       Subtype: Link
       Rect: 331, 202, 337, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 439, 197, 561, 206
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 187, 366, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 389, 187, 561, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 176, 321, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 148, 407, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 553, 148, 560, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 347, 112, 518, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 112, 561, 120
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 101, 468, 109
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 324, 95, 330, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 510, 79, 561, 88
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 69, 409, 77
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 73, 481, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 893
      Annotation: 
       Subtype: Link
       Rect: 535, 69, 561, 77
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 58, 432, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 733, 191, 741
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 193, 733, 197, 741
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 202, 733, 206, 741
       Flags: Print
       AppearanceDictionary: true
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 210, 733, 215, 741
       Flags: Print
       AppearanceDictionary: true
       Destination: 386
      Annotation: 
       Subtype: Link
       Rect: 268, 733, 294, 741
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 722, 250, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 722, 294, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 711, 194, 720
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 218, 711, 294, 720
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 701, 152, 709
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 452, 80, 552, 88
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 69, 345, 77
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 305, 227, 312
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 420, 551, 561, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 540, 362, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 328, 487, 483, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 403, 465, 554, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 444, 541, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 422, 507, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 540, 197, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 722, 421, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 530, 530, 554, 538
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 519, 470, 527
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 458, 344, 529, 351
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 333, 115, 341
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 119, 333, 199, 341
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 97d0e506
   Type: CRC32
  Checksum: 693ded5ff0eb3021935545c58537443e
   Type: MD5
  Checksum: e8556ab698ca774a5c21a202796e4078b3d18a2d
   Type: SHA-1
  Checksum: 5ef82ac273496c23656130d3b1a814d5101ffb31ced745683907890edf8b2f45
   Type: SHA-256