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2025-05-14 19:18:02 CEST Size: 1504772 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 536 FreeObjects: 21 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-­controlled clinical trial of GETECCU Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study design Item: Title: Treatment arms Item: Title: Eligibility criteria Item: Title: Randomisation and blinding Item: Title: Endpoints Item: Title: Assessments Children: Item: Title: Endoscopic assessment Item: Title: Radiological assessment Item: Title: Safety endpoints Item: Title: Withdrawal criteria Item: Title: Management of relapse Item: Title: Data collection Item: Title: Statistical analysis Children: Item: Title: Sample size Item: Title: Description of intention-to-treat and per-protocol populations and missing data Item: Title: Data presentation and analyses Item: Title: Results Children: Item: Title: Study population Item: Title: Sustained clinical remission at month 12 Item: Title: Endoscopic relapse at 12 months Item: Title: Radiological worsening at 12 months Item: Title: Biochemical relapse at 12 months Item: Title: Predictive factors of sustained clinical remission at 12 months Item: Title: Safety Item: Title: Quality of life Item: Title: Work productivity Item: Title: Discussion Item: Title: References Info: Title: Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled 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