0bb3eec9165ac5a2ac49c536a3cd59cb 310166.pdf 2496305ab7e007ec3c81fb643a4eebcffd7aefb8 310166.pdf 98fb0f321709df57c216945408708af504ebe0d01f0aa3339b88ac62e13ed996 310166.pdf Title: Efficacy and safety of antistaphylococcal penicillin or cephazolin-based combinations versus monotherapy for methicillin-susceptible Staphylococcus aureus infective endocarditis_ A propensity score analysis of nationwide prospective cohort Subject: Journal of Infection, 89 (2024) 106352. doi:10.1016/j.jinf.2024.106352 Keywords: Infective endocarditis; Staphylococcus aureus; Combination therapy; Prognosis; Mortality; Author: Jorge Calderón-Parra Creator: Elsevier Producer: Unknown CreationDate: Thu Dec 5 14:12:20 2024 CET ModDate: Thu Dec 5 14:13:14 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1194288 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LGFKHN+UniversLTStd Type 1C Custom yes yes yes 775 0 OTXRUQ+Gulliver Type 1C Custom yes yes yes 776 0 FAAEUI+Gulliver-Italic Type 1C Custom yes yes yes 777 0 FHSIVP+STIXGeneral-Regular Type 1C Custom yes yes yes 778 0 LMOGID+GulliverSCOsF Type 1C Custom yes yes yes 792 0 KVAQON+TimesNewRoman CID TrueType Identity-H yes yes yes 795 0 XEOKUA+Gulliver-Bold Type 1C Custom yes yes yes 32 0 JEPXJL+STIXGeneral-Italic Type 1C Custom yes yes yes 120 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-03 02:47:32 CEST RepresentationInformation: 310166.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-02 14:19:25 CEST Size: 1194288 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 855 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Efficacy and safety of antistaphylococcal penicillin or cephazolin-based combinations versus monotherapy for methicillin-sus... Destination: mk:titletit0005 Children: Item: Title: Introduction Destination: mk:H1_1 Item: Title: Patients and methods Destination: mk:H1_2 Children: Item: Title: Patients Destination: mk:H2_3 Item: Title: Definitions Destination: mk:H2_4 Item: Title: Endpoints Destination: mk:H2_5 Item: Title: Statistical analysis Destination: mk:H2_6 Item: Title: Results Destination: mk:H1_7 Children: Item: Title: Comparison of patients with monotherapy and combination treatment Destination: mk:H2_8 Item: Title: Propensity score-matched cohort Destination: mk:H2_9 Item: Title: Primary and secondary efficacy endpoints Destination: mk:H2_10 Item: Title: Safety endpoints Destination: mk:H2_11 Item: Title: Discussion Destination: mk:H1_12 Item: Title: Ethical approval statement Destination: mk:H1_13 Item: Title: Role of funding source Destination: mk:H1_14 Item: Title: Patients consent statement Destination: mk:H1_15 Item: Title: Data availability Destination: mk:H1_16 Item: Title: Declaration of Competing Interest Destination: mk:H1_17 Item: Title: Appendix A. Supporting information Destination: mk:H1_18 Item: Title: References Destination: mk:H1_19 Info: Title: Efficacy and safety of antistaphylococcal penicillin or cephazolin-based combinations versus monotherapy for methicillin-susceptible Staphylococcus aureus infective endocarditis_ A propensity score analysis of nationwide prospective cohort Author: Jorge Calderón-Parra Subject: Journal of Infection, 89 (2024) 106352. doi:10.1016/j.jinf.2024.106352 Keywords: Infective endocarditis; Staphylococcus aureus; Combination therapy; Prognosis; Mortality; Creator: Elsevier Producer: Unknown CreationDate: Thu Dec 05 14:42:20 CET 2024 ModDate: Thu Dec 05 14:43:14 CET 2024 ID: 0x864e8f8c5a718252bd2c0e1893e13664, 0x86661be39f354b489ac4403acf061a14 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 247 ImageHeight: 272 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: KVAQON+TimesNewRoman Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: XEOKUA+Gulliver-Bold FontSubset: true FirstChar: 1 LastChar: 43 FontDescriptor: FontName: XEOKUA+Gulliver-Bold Flags: Nonsymbolic, ForceBold FontBBox: -150, -250, 1131, 998 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LGFKHN+UniversLTStd FontSubset: true FirstChar: 1 LastChar: 27 FontDescriptor: FontName: LGFKHN+UniversLTStd Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OTXRUQ+Gulliver FontSubset: true FirstChar: 1 LastChar: 97 FontDescriptor: FontName: OTXRUQ+Gulliver Flags: Nonsymbolic FontBBox: -115, -251, 1042, 986 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LMOGID+GulliverSCOsF FontSubset: true FirstChar: 1 LastChar: 15 FontDescriptor: FontName: LMOGID+GulliverSCOsF Flags: Nonsymbolic FontBBox: -115, -251, 1407, 986 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JEPXJL+STIXGeneral-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JEPXJL+STIXGeneral-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FAAEUI+Gulliver-Italic FontSubset: true FirstChar: 1 LastChar: 77 FontDescriptor: FontName: FAAEUI+Gulliver-Italic Flags: Nonsymbolic, Italic FontBBox: -141, -232, 1053, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FHSIVP+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: FHSIVP+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -970, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: KVAQON+TimesNewRoman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KVAQON+TimesNewRoman Flags: Nonsymbolic FontBBox: -77, -225, 1009, 878 FontFile2: true XMP: application/pdf doi:10.1016/j.jinf.2024.106352 Elsevier Journal of Infection, 89 (2024) 106352. doi:10.1016/j.jinf.2024.106352 Infective endocarditis Staphylococcus aureus Combination therapy Prognosis Mortality Efficacy and safety of antistaphylococcal penicillin or cephazolin-based combinations versus monotherapy for methicillin-susceptible Staphylococcus aureus infective endocarditis_ A propensity score analysis of nationwide prospective cohort Jorge Calderón-Parra Sara Grillo Patricia Muñoz Marina Machado-Vilchez Antonia Delgado-Montero Arístides De Alarcón-González Manuel Poyato-Borrego MA Goenaga-Sánchez M. Carmen Fariñas-Alvarez José M. Miró Luis Eduardo López-Cortés Raquel Rodríguez-García José A. Oteo Antonio Martínez-Ramos on behalf of the Spanish Collaboration on Endocarditis (GAMES) journal Journal of Infection © 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. 0163-4453 89 6 106352 106352 10.1016/j.jinf.2024.106352 https://doi.org/10.1016/j.jinf.2024.106352 2010-04-23 true 10.1016/j.jinf.2024.106352 elsevier.com sciencedirect.com 7.0 10.1016/j.jinf.2024.106352 noindex 2010-04-23 true elsevier.com sciencedirect.com VoR Elsevier 2024-12-05T18:43:14+05:30 2024-12-05T18:42:20+05:30 2024-12-05T18:43:14+05:30 True Infective endocarditis; Staphylococcus aureus; Combination therapy; Prognosis; Mortality; Unknown uuid:c5e49fcf-6525-4d35-b3ec-7e3d2d05b479 uuid:9b677cfd-bc0d-49f6-af61-0e0bc41e8c54 https://creativecommons.org/licenses/BY-NC-ND/4.0/ Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 323, 722, 374, 730 Flags: Print Annotation: Subtype: Link Rect: 279, 666, 399, 674 Flags: Print Annotation: Subtype: Link Rect: 36, 729, 36, 741 Flags: Print Annotation: Subtype: Link Rect: 141, 541, 145, 552 Flags: Print Destination: 734 Annotation: Subtype: Link 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