426c9349d7a1df8ff86e353119e3c391 310167.pdf 3e475255fd124fa0aa7a47f83b27ef0a441011d7 310167.pdf d3d6d4c0686aea47cf79e88797d16587a897cb25782c0d837274e145c1fb8009 310167.pdf Title: Intradialytic Parenteral Nutrition in Patients on Hemodialysis: A Multicenter Retrospective Study Subject: Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a “routinely collected data bank” in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72.4 12.0 years, and 24 (42.9%) were women. In the overall study sample, MIS significantly decreased from 16.4 (95%CI: 15.3–17.65) at baseline to 14.3 (95%CI: 12.8–15.8) at the last follow-up visit on IDPN (p = 0.0019). Fifteen (26.8%) patients achieved a MIS reduction 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89.3% versus 66.1%, respectively, p = 0.0023). Regarding analytical parameters, serum albumin (p = 0.0003) and total proteins (p = 0.0024) significantly increased after IDPN administration. Throughout the study’s follow-up period, 45 (80.4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration > 3 months significantly improved the nutritional status of patients evaluated by the MIS test. Keywords: intradialytic parenteral nutrition; protein-energy wasting; hemodialysis; chronic kidney disease; malnutrition inflammation score Author: Marta Arias-Guillén, Juan Carlos González, Loreley Betancourt, Elisabeth Coll, Silvia Collado, Bárbara Romano-Andrioni, Ascensión Lupiañez-Barbero, Julia Garro, Verónica Duarte, Jordi Soler-Majoral and Jordi Calabia Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sun Nov 24 09:13:03 2024 CET ModDate: Sun Nov 24 09:14:22 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 663014 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZZTQUO+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 VJTQVM+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 OICMOZ+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 TFBBDH+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 KOSUXD+CMSY10 Type 1 Builtin yes yes yes 32 0 OPZDHV+VnURWPalladioL Type 1 Custom yes yes yes 37 0 MBOBLI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 84 0 MBOBLJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 87 0 MBOBLK+PalatinoLinotype TrueType WinAnsi yes yes no 93 0 MBOBLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 96 0 MBOCBL+PalatinoLinotype TrueType MacRoman yes yes no 99 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 110 0 MBOEIP+PalatinoLinotype,Italic TrueType MacRoman yes yes no 126 0 MBOBLI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 129 0 MBOBLJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 132 0 MBOBLK+PalatinoLinotype TrueType WinAnsi yes yes no 138 0 MBOBLM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 141 0 MBOCBL+PalatinoLinotype TrueType MacRoman yes yes no 144 0 MBOECB+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 147 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes yes 155 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-04 02:43:24 CEST RepresentationInformation: 310167.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-03 10:48:36 CEST Size: 663014 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 294 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Participants Destination: subsection.2.2 Item: Title: IDPN Composition Destination: subsection.2.3 Item: Title: Study Groups Destination: subsection.2.4 Item: Title: Study Outcomes Destination: subsection.2.5 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Demographic, Clinical, Analytical, and Nutritional Characteristics Destination: subsection.3.1 Item: Title: Malnutrition Inflammation Score Destination: subsection.3.2 Item: Title: Other Analytic- and Nutrition-Related Variables Destination: subsection.3.3 Item: Title: Nutritional and Analytical Parameters Depending on IDPN Duration Destination: subsection.3.4 Item: Title: Safety Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Intradialytic Parenteral Nutrition in Patients on Hemodialysis: A Multicenter Retrospective Study Author: Marta Arias-Guillén, Juan Carlos González, Loreley Betancourt, Elisabeth Coll, Silvia Collado, Bárbara Romano-Andrioni, Ascensión Lupiañez-Barbero, Julia Garro, Verónica Duarte, Jordi Soler-Majoral and Jordi Calabia Subject: Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a “routinely collected data bank” in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72.4 12.0 years, and 24 (42.9%) were women. In the overall study sample, MIS significantly decreased from 16.4 (95%CI: 15.3 17.65) at baseline to 14.3 (95%CI: 12.8 15.8) at the last follow-up visit on IDPN (p = 0.0019). Fifteen (26.8%) patients achieved a MIS reduction 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89.3% versus 66.1%, respectively, p = 0.0023). Regarding analytical parameters, serum albumin (p = 0.0003) and total proteins (p = 0.0024) significantly increased after IDPN administration. Throughout the study’s follow-up period, 45 (80.4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration > 3 months significantly improved the nutritional status of patients evaluated by the MIS test. 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