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Medina-Herrera Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Apr 26 09:44:55 2024 CEST ModDate: Mon Apr 29 12:47:49 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2309719 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LFJCNC+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 58 0 LFJCMA+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 59 0 LFJCND+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 773 0 LFJCMB+AdvMyriad_I Type 1C WinAnsi yes yes no 774 0 LFJCMC+AdvMyriad_R Type 1C WinAnsi yes yes no 60 0 LFJCNE+AdvTTab7e17fd Type 1C WinAnsi yes yes no 66 0 LFJCNF+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 67 0 LFJAGI+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 775 0 Arial-BoldMT Type 1C WinAnsi yes no no 776 0 LFJALI+AdvOT46dcae81 Type 1C WinAnsi yes yes no 63 0 LFJAMJ+AdvOT46dcae81+fb Type 1C Custom yes yes yes 65 0 LFJAMK+AdvTT6780a46b Type 1C WinAnsi yes yes no 88 0 LFJAOK+AdvTT2876772e+27 Type 1C Custom yes yes yes 381 0 LFJDCH+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 61 0 LFJDBF+AdvOT46dcae81+22 Type 1C Custom yes yes yes 62 0 LFJDCG+AdvOT46dcae81+03 Type 1C Custom yes yes yes 64 0 LFJJIF+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 82 0 LFJJIG+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 83 0 LFJJIE+AdvTT6780a46b+fb Type 1C Custom yes yes yes 84 0 LFJDFH+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 85 0 LFJIHJ+AdvOT919a0533.B Type 1C WinAnsi yes yes no 86 0 LFJDFG+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 87 0 LFKAEN+AdvTT6780a46b+22 Type 1C Custom yes yes yes 116 0 LFKAIN+AdvOT65f8a23b.I+03 Type 1C Custom yes yes yes 136 0 LFKAIM+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 137 0 LFKAOM+AdvTTab7e17fd+22 Type 1C Custom yes yes no 165 0 LFKELG+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 199 0 Arial-BoldMT2 Type 1C Custom yes no yes 200 0 LFKKOC+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 380 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-05-15 02:55:58 CEST RepresentationInformation: 310571.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-05-14 19:39:30 CEST Size: 2309719 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 914 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression Destination: title_link Children: Item: Title: Introduction Destination: A1 Item: Title: Methods Destination: A2 Children: Item: Title: Patients Destination: B1 Item: Title: Sample collection Destination: B2 Item: Title: Next-generation sequencing’panel Destination: B3 Item: Title: Pipeline for next-generation sequencing analysis Destination: B4 Item: Title: FISH studies Destination: B5 Item: Title: Statistical analysis Destination: B6 Item: Title: Results Destination: A3 Children: Item: Title: Patient characteristics Destination: B7 Item: Title: Mutational profile of high-risk and ultrahigh-risk SMM patients Destination: B8 Item: Title: The mutational profile of high-risk SMM patients is intermediate between SMM’and MM Destination: B9 Item: Title: Molecular and clinical associations in high-risk’SMM Destination: B10 Item: Title: Genomic predictors of treatment resistance and progression in high-risk SMM patients Destination: B11 Item: Title: Discussion Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: ACKNOWLEDGMENTS Destination: M1 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression Author: A. 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Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41408-024-01053-3 The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression A. Medina-Herrera I. Vazquez I. Cuenca J. M. Rosa-Rosa B. Ariceta C. Jimenez M. Fernandez-Mercado M. J. Larrayoz N. C. Gutierrez M. Fernandez-Guijarro V. Gonzalez-Calle P. Rodriguez-Otero A. Oriol L. Rosiñol A. Alegre F. Escalante J. Rubia A. I. Teruel F. Arriba M. T. Hernandez J. Lopez-Jimenez E. M. Ocio N. Puig B. Paiva J. J. Lahuerta J. Bladé J. F. San Miguel M. V. Mateos J. Martinez-Lopez M. J. Calasanz R. Garcia-Sanz V. Gonzalez-Calle J. Rubia F. Arriba R. Rios A. Sureda M. J. Blanchard R. Martinez-Martinez J. M. Moraleda J. Bargay M. Gironella L. Palomera Y. Gonzalez-Montes J. M. Martí I. Krsnik J. M. Arguiñano M. E. Gonzalez A. P. Gonzalez L. F. 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