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Title:           SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF
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 Date: 2025-05-17 04:16:52 CEST
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     Item: 
      Title: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF
      Children: 
       Item: 
        Title: Significance
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Depletion of SIRT7 Increases ARF Levels in the Epithelial Cells of the Lung.
         Item: 
          Title: SIRT7 Destabilizes ARF Protein by Promoting Ubiquitination and Proteasomal-Dependent Degradation.
         Item: 
          Title: SIRT7 Directly Interacts with ARF to Prevent Interactions with NPM, Thereby Reducing ARF Stability.
         Item: 
          Title: SIRT7 Stimulates the Expression of Genes Involved in Lung Cancer Progression in an ARF-Dependent Manner.
         Item: 
          Title: SIRT7 Depletion Attenuates Proliferation of NSLC Cells in an ARF-Dependent Manner.
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Cell Culture and Treatment.
         Item: 
          Title: Generation of Stable and KO Cell Lines.
         Item: 
          Title: Coimmunoprecipitation and Western Blotting.
         Item: 
          Title: RNA-Sequencing.
         Item: 
          Title: RNA Extraction and RT-qPCR.
         Item: 
          Title: ChIP.
         Item: 
          Title: Plasmids and Cloning.
         Item: 
          Title: IF.
         Item: 
          Title: Mice and Xenograft Experiments.
         Item: 
          Title: Analysis of Public Datasets.
         Item: 
          Title: Statistical Analysis.
       Item: 
        Title: Data, Materials, and Software Availability
       Item: 
        Title: ACKNOWLEDGMENTS
       Item: 
        Title: Supporting Information
        Children: 
         Item: 
          Title: Anchor 32
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