b9ca95e4528f507ac2261df0fb197bbe 1-s2.0-S2588931124000257-main.pdf a726991e7cd85db20e95b7006075dfd13b57ab08 1-s2.0-S2588931124000257-main.pdf 8f1946a333a1ec38b91d380b9c2b21f44cbd3da79cf7b5c35c1ec98e2754f81c 1-s2.0-S2588931124000257-main.pdf Title: Development and Independent Validation of a Prognostic Gene Expression Signature Based on RB1, PTEN, and TP53 in Metastatic Hormone-sensitive Prostate Cancer Patients Subject: European Urology Oncology, 7 (2024) 954-964. doi:10.1016/j.euo.2023.12.012 Author: Natalia Jiménez Creator: Elsevier Producer: Acrobat Distiller 24.0 (Windows) CreationDate: Sat Jul 13 13:49:16 2024 CEST ModDate: Sat Jul 13 13:49:32 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2043835 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LCKFMM+AdvGulliv-B Type 1C Custom yes yes no 713 0 LCKFNM+AdvP4DF612 Type 1C Custom yes yes no 714 0 LCKFNN+AdvGulliv-R Type 1C MacRoman yes yes no 715 0 LCKFNO+AdvP4DF611 Type 1C WinAnsi yes yes no 723 0 LCKFNP+AdvGulliv-I Type 1C WinAnsi yes yes no 724 0 LCKFPA+AdvPSSym Type 1C Custom yes yes no 729 0 LCKFPB+AdvPSHEL-B Type 1C WinAnsi yes yes no 734 0 LCKKDI+AdvP4C4E74 Type 1C Custom yes yes no 366 0 LCKKLH+Arial-BoldMT Type 1C WinAnsi yes yes no 370 0 LCKKNH+Calibri Type 1C WinAnsi yes yes no 385 0 LCKKOI+ArialMT Type 1C WinAnsi yes yes no 390 0 LCKLBI+Arial-ItalicMT Type 1C WinAnsi yes yes no 382 0 LCKLBJ+Arial-Black Type 1C WinAnsi yes yes no 371 0 LCKLBK+MyriadPro-Regular Type 1C Custom yes yes no 387 0 LCKLEJ+AdvGulli-BI Type 1C WinAnsi yes yes no 384 0 LCKKIH+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 377 0 LCKMAG+MyriadPro-Regular Type 1C Custom yes yes no 396 0 LCKOFJ+Calibri-Bold Type 1C WinAnsi yes yes no 399 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-05-17 04:16:50 CEST RepresentationInformation: 1-s2.0-S2588931124000257-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-05-16 15:34:17 CEST Size: 2043835 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'web64para103' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para87' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para102' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para86' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para89' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para105' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para88' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para104' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para92' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para107' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para90' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para99' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para100' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para85' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para78' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para71' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para96' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para76' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para97' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'hs0090' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para94' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para80' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para95' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para91' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para106' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para93' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para84' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para98' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para101' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para93' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para106' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para92' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para107' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para95' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para104' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para94' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para105' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para98' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para102' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para100' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para96' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para89' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para91' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para84' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'hs0090' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para85' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para86' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-122 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Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-122 Offset: 2015716 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para97' cannot be found ID: PDF-HUL-122 Offset: 2015716 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 778 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Development and Independent Validation of a Prognostic Gene Expression Signature Based on RB1, PTEN, and TP53 in Metastatic Hormone-sensitive Prostate Cancer Patients Destination: 1 Children: Item: Title: 1 Introduction Destination: 1 Item: Title: 2 Patients and methods Destination: 1 Children: Item: Title: 2.1 Design, patients, and samples Destination: 1 Item: Title: 2.2 Gene expression panel design Destination: 1 Item: Title: 2.3 Bioinformatics and statistical analysis Destination: 1 Item: Title: 3 Results Destination: 1 Children: Item: Title: 3.1 Patients, samples, and TSG expression signature Destination: 1 Item: Title: 3.2 Comparison between TSG determination by nCounter and other techniques Destination: 1 Item: Title: 3.3 TSG mRNA expression signature in an exploratory cohort Destination: 1 Item: Title: 3.4 TSG mRNA expression signature validation in patients treated with ADT + D Destination: 1 Item: Title: 3.5 TSG mRNA expression signature in patients treated with ADT alone Destination: 1 Item: Title: 3.6 Exploring TSG mRNA expression as a predictor of treatment benefit Destination: 1 Item: Title: 3.7 Independent series validation Destination: 1 Item: Title: 3.8 Individual assessment of TSG Destination: 1 Item: Title: 4 Discussion Destination: 1 Item: Title: 5 Conclusions Destination: 1 Item: Title: Appendix A Supplementary data Destination: 1 Item: Title: References Destination: 1 Info: Title: Development and Independent Validation of a Prognostic Gene 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FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LCKFPB+AdvPSHEL-B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: LCKFPB+AdvPSHEL-B Flags: Nonsymbolic FontBBox: -166, -218, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LCKLBI+Arial-ItalicMT FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: LCKLBI+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.euo.2023.12.012 Development and Independent Validation of a Prognostic Gene Expression Signature Based on RB1, PTEN, and TP53 in Metastatic Hormone-sensitive Prostate Cancer Patients Natalia Jiménez Marta Garcia de Herreros Òscar Reig Mercedes Marín-Aguilera Caterina Aversa Laura Ferrer-Mileo Samuel García-Esteve Leonardo Rodríguez-Carunchio Isabel Trias Albert Font Alejo Rodriguez-Vida Miguel Ángel Climent Sara Cros Isabel Chirivella Montserrat Domènech Mariona Figols Joan Carles Cristina Suárez Daniel Herrero Rivera Enrique González-Billalabeitia Claudia Cívico Núria Sala-González Vicenç Ruiz de Porras Maria J. Ribal Aleix Prat Begoña Mellado Hormone-sensitive prostate cancer Tumor suppressor genes Biomarkers Androgen deprivation therapy Docetaxel CHAARTED trial European Urology Oncology, 7 (2024) 954-964. doi:10.1016/j.euo.2023.12.012 The Author(s) journal European Urology Oncology © 2024 The Author(s). 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