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Title:           Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation
Subject:         CellReports, 43 (2024) 114736. doi:10.1016/j.celrep.2024.114736
Author:          Wei Wang
Creator:         Elsevier
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     Item: 
      Title: Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR sti ...
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Results
        Destination: flink2
        Children: 
         Item: 
          Title: Butyrate and propionate decrease the LPS-driven cytokine response but trigger IL-1β release
          Destination: slink3
         Item: 
          Title: SCFA-mediated IL-1β release is dependent on the NLRP3 inflammasome
          Destination: slink4
         Item: 
          Title: Inhibition of HDACs 1–3, 8, and 10 is sufficient to trigger NLRP3-dependent IL-1β release
          Destination: slink5
         Item: 
          Title: Butyrate and propionate modulate the LPS-driven gene expression profile
          Destination: slink6
         Item: 
          Title: SCFAs decrease expression of cFLIP and XIAP
          Destination: slink7
         Item: 
          Title: Butyrate-dependent ablation of cFLIP is required for NLRP3 inflammasome activation
          Destination: slink8
         Item: 
          Title: Butyrate-mediated NLRP3 activation is dependent on caspase-8
          Destination: slink9
         Item: 
          Title: Butyrate-mediated NLRP3 activation is restrained by RIPK1-mediated regulation of caspase-8
          Destination: slink10
         Item: 
          Title: Loss of IL-10 secretion is required for butyrate-driven NLRP3 inflammasome activation
          Destination: slink11
         Item: 
          Title: Butyrate-mediated NLRP3 activation does not trigger cell death but causes gasdermin-D-independent IL-1β secretion
          Destination: slink12
       Item: 
        Title: Discussion
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        Children: 
         Item: 
          Title: Limitations of the study
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       Item: 
        Title: Resource availability
        Destination: flink15
        Children: 
         Item: 
          Title: Lead contact
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         Item: 
          Title: Material availability
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         Item: 
          Title: Data and code availability
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Declaration of interests
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       Item: 
        Title: Supplemental information
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       Item: 
        Title: References
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       Item: 
        Title: STAR★Methods
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         Item: 
          Title: Key resources table
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         Item: 
          Title: Experimental model and subject details
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         Item: 
          Title: Method details
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          Children: 
           Item: 
            Title: Isolation and culturing of primary human macrophages
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           Item: 
            Title: Inflammasome stimulation
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           Item: 
            Title: Measurement of cytokine secretion
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           Item: 
            Title: Caspase-8 activity assay
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           Item: 
            Title: Lactate dehydrogenase (LDH) assay
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           Item: 
            Title: Small interfering RNA (siRNA) electroporation in primary human macrophages
            Destination: tlink6
           Item: 
            Title: Cloning
            Destination: tlink7
           Item: 
            Title: Lentiviral transduction of primary human macrophages
            Destination: tlink8
           Item: 
            Title: Cellular potassium quantification
            Destination: tlink9
           Item: 
            Title: Immunoblotting
            Destination: tlink10
           Item: 
            Title: Simple Western assay on WesTM
            Destination: tlink11
           Item: 
            Title: Live cell imaging for cell death analysis
            Destination: tlink12
           Item: 
            Title: ASC speck imaging and quantitation
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           Item: 
            Title: Gene expression analysis by quantitative PCR (qPCR)
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           Item: 
            Title: RNA-sequencing
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           Item: 
            Title: RNA-sequencing analysis
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           Item: 
            Title: ChIP-seq
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           Item: 
            Title: ChIP-seq data processing
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           Item: 
            Title: GSEA
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           Item: 
            Title: Motif enrichment
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           Item: 
            Title: Mass spectrometry-based proteomics (MS)
            Destination: tlink21
           Item: 
            Title: MS data processing and analysis
            Destination: tlink22
         Item: 
          Title: Quantification and statistical analysis
          Destination: slink27
   Info: 
    Title: Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation
    Author: Wei Wang
    Subject: CellReports, 43 (2024) 114736. doi:10.1016/j.celrep.2024.114736
    Creator: Elsevier
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    CreationDate: Thu Sep 19 21:59:30 CEST 2024
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