49c9b31d4a1ce9be2adf657f6fad1d32 1-s2.0-S0753332224007418-main.pdf 5e43b96e44ab53fe3bc4216fe61116903ad427e4 1-s2.0-S0753332224007418-main.pdf 96bcbdf0122ac6605a0bdc77d7a87223c63ee7288a2afbad1a51ce0c5c0d3c83 1-s2.0-S0753332224007418-main.pdf Title: Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment Subject: Biomedicine & Pharmacotherapy, 176 (2024) 116857. doi:10.1016/j.biopha.2024.116857 Keywords: Colorectal cancer,Oxaliplatin,predictive biomarkers,Luminex,CXCL13,Tertiary Lymphoid Structures (TLS) Author: Sara Cabrero-de las Heras Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Jun 15 20:34:08 2024 CEST ModDate: Sat Jun 15 21:00:57 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2251862 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WUMNCX+CharisSIL CID TrueType Identity-H yes yes yes 667 0 MYKGZH+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 672 0 VPUEKC+STIXGeneral Type 1C Custom yes yes yes 677 0 VXCJFZ+Univers Type 1C Builtin yes yes yes 682 0 WNKGDC+STIX-Italic Type 1C Custom yes yes yes 686 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 691 0 ZEBFVS+STIX-Regular Type 1C Custom yes yes yes 695 0 KPDFRW+CharisSIL-Italic CID TrueType Identity-H yes yes yes 700 0 JYXSFK+CharisSIL CID TrueType Identity-H yes yes yes 658 0 PNFJFJ+CharisSIL-Bold CID TrueType Identity-H yes yes yes 258 0 LLSPPP+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 263 0 YHXIII+CharisSIL-Italic CID TrueType Identity-H yes yes yes 251 0 FCFHUH+TimesNewRomanPS-ItalicMT CID TrueType Identity-H yes yes yes 21 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 272 0 GNZFDN+TeX_CM_Bold_Maths_Symbols Type 1C Builtin yes yes yes 52 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-05-28 02:56:19 CEST RepresentationInformation: 1-s2.0-S0753332224007418-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-05-27 15:14:15 CEST Size: 2251862 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'sec0105' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec0105' cannot be found ID: PDF-HUL-122 Offset: 2212509 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 794 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin ... Destination: mk:title Children: Item: Title: 1 Background Destination: mk:H1_1 Item: Title: 2 Patients and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study design and patients Destination: mk:H2_1 Item: Title: 2.2 Sample collection, processing and storage Destination: mk:H2_2 Item: Title: 2.3 Luminex® analysis Destination: mk:H2_3 Item: Title: 2.4 CXCL13 in silico analysis Destination: mk:H2_4 Item: Title: 2.5 Nanostring experiments Destination: mk:H2_5 Item: Title: 2.6 Validation cohort Destination: mk:H2_6 Item: Title: 2.7 ELISA assay Destination: mk:H2_7 Item: Title: 2.8 Statistical methods Destination: mk:H2_8 Children: Item: Title: 2.8.1 Analysis of Luminex Study Findings Destination: mk:H3_9 Item: Title: 2.8.2 CXCL13 in silico analysis Destination: mk:H3_10 Item: Title: 2.8.3 Nanostring experiments Destination: mk:H3_11 Item: Title: 2.8.4 Validation studies Destination: mk:H3_12 Item: Title: 3 Results Destination: mk:H1_3 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of Generative AI and AI-assisted technologies in the writing process Destination: mk:H1_6 Item: Title: Declaration of Competing Interest Destination: mk:HH1_2 Item: Title: Data availability Destination: datalink3 Item: Title: Acknowledgements Destination: mk:HH1_4 Item: Title: Author contributions Destination: mk:H1_7 Item: Title: Appendix A Supporting information Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment Author: Sara Cabrero-de las Heras Subject: Biomedicine & Pharmacotherapy, 176 (2024) 116857. doi:10.1016/j.biopha.2024.116857 Keywords: Colorectal cancer,Oxaliplatin,predictive biomarkers,Luminex,CXCL13,Tertiary Lymphoid Structures (TLS) Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Jun 15 20:34:08 CEST 2024 ModDate: Sat Jun 15 21:00:57 CEST 2024 ID: 0xa5493931a7310eca436f3afec416c276, 0x9b1b8f5a37e3120d3338353d2575147a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: MYKGZH+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: PNFJFJ+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: FCFHUH+TimesNewRomanPS-ItalicMT Encoding: Identity-H ToUnicode: true Font: BaseFont: WUMNCX+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: KPDFRW+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: GNZFDN+TeX_CM_Bold_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 255 FontDescriptor: FontName: GNZFDN+TeX_CM_Bold_Maths_Symbols Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VPUEKC+STIXGeneral FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: VPUEKC+STIXGeneral Flags: Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZEBFVS+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: ZEBFVS+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LLSPPP+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: LLSPPP+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VXCJFZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VXCJFZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: WNKGDC+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: WNKGDC+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: MYKGZH+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MYKGZH+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: PNFJFJ+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PNFJFJ+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: FCFHUH+TimesNewRomanPS-ItalicMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FCFHUH+TimesNewRomanPS-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -498, -307, 1120, 1023 FontFile2: true Font: BaseFont: WUMNCX+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WUMNCX+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: KPDFRW+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KPDFRW+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: application/pdf 10.1016/j.biopha.2024.116857 Elsevier Masson SAS Biomedicine & Pharmacotherapy, 176 (2024) 116857. doi:10.1016/j.biopha.2024.116857 Colorectal cancer Oxaliplatin predictive biomarkers Luminex CXCL13 Tertiary Lymphoid Structures (TLS) Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment Sara Cabrero-de las Heras Xavier Hernández-Yagüe Andrea González Ferran Losa Gemma Soler Cristina Bugés Iosune Baraibar Anna Esteve Miguel Ángel Pardo-Cea Anne Hansen Ree Neus Martínez-Bosch Maria Nieva Eva Musulén Sebastian Meltzer Tania Lobato Carla Vendrell-Ayats Cristina Queralt Pilar Navarro Clara Montagut Ferran Grau-Leal David Camacho Raquel Legido Núria Mulet-Margalef Eva Martínez-Balibrea journal Biomedicine & Pharmacotherapy © 2024 The Author(s). Published by Elsevier Masson SAS. 0753-3322 176 1 July 2024 2024-07-01 116857 116857 10.1016/j.biopha.2024.116857 https://doi.org/10.1016/j.biopha.2024.116857 2010-04-23 true 10.1016/j.biopha.2024.116857 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc/4.0/ VoR 10.1016/j.biopha.2024.116857 noindex 2010-04-23 true 15th June 2024 sciencedirect.com elsevier.com Elsevier 2024-06-15T19:00:57 2024-06-15T18:34:08 2024-06-15T19:00:57 True 15th June 2024 Acrobat Distiller 8.1.0 (Windows) Colorectal cancer,Oxaliplatin,predictive biomarkers,Luminex,CXCL13,Tertiary Lymphoid Structures (TLS) uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 1 https://www.elsevier.com/tdm/tdmrep-policy.json Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 158, 559, 165, 569 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 165, 559, 172, 569 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 173, 554, 300, 565 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 300, 559, 306, 569 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 307, 554, 398, 565 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 398, 559, 404, 569 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 405, 554, 469, 565 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 469, 559, 475, 569 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 476, 554, 483, 565 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 102, 541, 182, 552 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 182, 546, 188, 556 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 189, 541, 273, 552 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 273, 546, 278, 556 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 279, 541, 347, 552 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 347, 546, 353, 556 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 354, 546, 359, 556 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 360, 541, 467, 552 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 56, 533, 61, 543 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 61, 528, 159, 539 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 159, 533, 166, 543 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 167, 528, 278, 539 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 278, 528, 349, 539 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 349, 528, 422, 539 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 422, 533, 427, 543 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 428, 528, 434, 539 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 122, 515, 196, 526 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 196, 515, 306, 526 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 306, 520, 312, 530 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 313, 515, 400, 526 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 400, 520, 407, 530 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 407, 515, 415, 526 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 102, 507, 109, 518 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 110, 507, 115, 518 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 115, 502, 201, 513 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 201, 507, 208, 518 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 209, 502, 301, 513 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 301, 507, 307, 518 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 308, 502, 394, 513 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 394, 502, 476, 513 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 476, 502, 483, 513 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 141, 494, 147, 505 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 148, 489, 263, 500 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 263, 494, 269, 505 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 270, 494, 276, 505 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 277, 497, 281, 502 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 277, 489, 281, 500 Flags: Print Destination: 643 Annotation: Subtype: Link Rect: 98, 123, 188, 130 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 188, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 212, 748, 381, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 40, 49, 196, 61 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 259, 457, 270, 464 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 37, 341, 48, 349 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 207, 195, 226, 203 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 37, 101, 55, 109 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 452, 488, 463, 496 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 544, 436, 555, 444 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 527, 373, 543, 381 Flags: Print Destination: 149 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 235, 541, 288, 549 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 531, 68, 539 Flags: Print Destination: null Annotation: Subtype: Link Rect: 68, 446, 88, 454 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 306, 352, 333, 360 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 309, 279, 448, 286 Flags: Print Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 103, 636, 119, 644 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 238, 636, 254, 644 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 127, 626, 142, 634 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 125, 605, 141, 613 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 122, 584, 138, 592 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 129, 437, 215, 445 Flags: Print Destination: null Annotation: Subtype: Link Rect: 113, 165, 128, 173 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 173, 92, 261, 100 Flags: Print Destination: null Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 263, 458, 283, 466 Flags: Print Destination: 14 Annotation: Subtype: Link Rect: 46, 405, 73, 413 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 89, 311, 175, 319 Flags: Print Destination: null Annotation: Subtype: Link Rect: 264, 186, 283, 194 Flags: Print Destination: 65 Annotation: Subtype: Link Rect: 89, 102, 110, 110 Flags: Print Destination: 65 Annotation: Subtype: Link Rect: 526, 136, 547, 144 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 428, 105, 448, 113 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 455, 94, 481, 102 Flags: Print Destination: 46 Annotation: Subtype: Link Rect: 306, 73, 395, 81 Flags: Print Destination: null Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 67, 244, 88, 252 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 224, 192, 244, 200 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 180, 161, 200, 168 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 74, 77, 94, 85 Flags: Print Destination: 81 Annotation: Subtype: Link Rect: 346, 296, 434, 304 Flags: Print Destination: null Annotation: Subtype: Link Rect: 453, 296, 474, 304 Flags: Print Destination: 90 Annotation: Subtype: Link Rect: 441, 150, 461, 158 Flags: Print Destination: 90 Annotation: Subtype: Link Rect: 309, 87, 406, 95 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 66, 403, 74 Flags: Print Destination: null Page: Label: 7 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 259, 283, 286, 291 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 195, 241, 285, 249 Flags: Print Destination: null Annotation: Subtype: Link Rect: 262, 210, 288, 218 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 37, 200, 49, 208 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 84, 158, 104, 166 Flags: Print Destination: 110 Annotation: Subtype: Link Rect: 40, 126, 60, 134 Flags: Print Destination: 110 Annotation: Subtype: Link Rect: 189, 95, 210, 103 Flags: Print Destination: 110 Annotation: Subtype: Link Rect: 235, 95, 288, 103 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 85, 71, 93 Flags: Print Destination: null Annotation: Subtype: Link Rect: 386, 304, 406, 312 Flags: Print Destination: 110 Annotation: Subtype: Link Rect: 371, 221, 392, 229 Flags: Print Destination: 126 Annotation: Subtype: Link Rect: 309, 95, 329, 103 Flags: Print Destination: 126 Annotation: Subtype: Link Rect: 448, 64, 477, 72 Flags: Print Destination: 149 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 254, 220, 269, 228 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 222, 199, 237, 207 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 105, 189, 121, 197 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 272, 178, 288, 186 Flags: Print Destination: null Annotation: Subtype: Link Rect: 37, 168, 109, 176 Flags: Print Destination: null Annotation: Subtype: Link Rect: 89, 115, 109, 123 Flags: Print Destination: 126 Annotation: Subtype: Link Rect: 439, 178, 535, 186 Flags: Print Destination: null Annotation: Subtype: Link Rect: 427, 147, 552, 155 Flags: Print Destination: null Annotation: Subtype: Link Rect: 365, 126, 491, 134 Flags: Print Destination: null Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 306, 219, 322, 227 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 500, 157, 516, 165 Flags: Print Destination: 218 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 239, 678, 255, 686 Flags: Print Destination: 149 Annotation: Subtype: Link Rect: 37, 626, 64, 634 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 187, 573, 203, 581 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 174, 469, 190, 477 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 223, 437, 239, 445 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 196, 375, 223, 383 Flags: Print Destination: 218 Annotation: Subtype: Link Rect: 221, 312, 236, 320 Flags: Print Destination: 218 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 99, 270, 223, 278 Flags: Print Annotation: Subtype: Link Rect: 53, 207, 157, 214 Flags: Print Annotation: Subtype: Link Rect: 126, 175, 260, 182 Flags: Print Annotation: Subtype: Link Rect: 154, 151, 245, 158 Flags: Print Annotation: Subtype: Link Rect: 53, 144, 109, 150 Flags: Print Annotation: Subtype: Link Rect: 226, 128, 272, 134 Flags: Print Annotation: Subtype: Link Rect: 53, 120, 138, 126 Flags: Print Annotation: Subtype: Link Rect: 53, 96, 149, 102 Flags: Print Annotation: Subtype: Link Rect: 82, 72, 187, 78 Flags: Print Annotation: Subtype: Link Rect: 380, 716, 507, 722 Flags: Print Annotation: Subtype: Link Rect: 430, 684, 553, 690 Flags: Print Annotation: Subtype: Link Rect: 322, 644, 453, 651 Flags: Print Annotation: Subtype: Link Rect: 452, 604, 553, 611 Flags: Print Annotation: Subtype: Link Rect: 399, 572, 530, 579 Flags: Print Annotation: Subtype: Link Rect: 477, 541, 549, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 382, 539 Flags: Print Annotation: Subtype: Link Rect: 365, 501, 496, 507 Flags: Print Annotation: Subtype: Link Rect: 452, 469, 553, 475 Flags: Print Annotation: Subtype: Link Rect: 510, 437, 555, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 421, 435 Flags: Print Annotation: Subtype: Link Rect: 492, 373, 537, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 365, 385, 372 Flags: Print Annotation: Subtype: Link Rect: 474, 333, 546, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 378, 332 Flags: Print Annotation: Subtype: Link Rect: 510, 294, 555, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 408, 292 Flags: Print Annotation: Subtype: Link Rect: 434, 246, 509, 252 Flags: Print Annotation: Subtype: Link Rect: 323, 238, 382, 244 Flags: Print Annotation: Subtype: Link Rect: 351, 214, 478, 220 Flags: Print Annotation: Subtype: Link Rect: 461, 182, 555, 188 Flags: Print Annotation: Subtype: Link Rect: 323, 174, 355, 180 Flags: Print Annotation: Subtype: Link Rect: 383, 166, 478, 172 Flags: Print Annotation: Subtype: Link Rect: 478, 134, 549, 140 Flags: Print Annotation: Subtype: Link Rect: 323, 126, 392, 133 Flags: Print Annotation: Subtype: Link Rect: 351, 102, 468, 109 Flags: Print Annotation: Subtype: Link Rect: 323, 78, 451, 85 Flags: Print Annotation: Subtype: Link Rect: 375, 62, 492, 69 Flags: Print Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 181, 724, 284, 730 Flags: Print Annotation: Subtype: Link Rect: 116, 708, 239, 714 Flags: Print Annotation: Subtype: Link Rect: 162, 684, 284, 690 Flags: Print Annotation: Subtype: Link Rect: 182, 636, 278, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 77, 635 Flags: Print Annotation: Subtype: Link Rect: 138, 596, 269, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 178, 571 Flags: Print Annotation: Subtype: Link Rect: 82, 541, 208, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 450, 571 Flags: Print Annotation: Subtype: Link Rect: 483, 525, 555, 531 Flags: Print Annotation: Subtype: Link Rect: 323, 517, 381, 523 Flags: Print Annotation: Subtype: Link Rect: 346, 493, 490, 499 Flags: Print Annotation: Subtype: Link Rect: 418, 469, 553, 475 Flags: Print Checksum: 0f709d61 Type: CRC32 Checksum: 49c9b31d4a1ce9be2adf657f6fad1d32 Type: MD5 Checksum: 5e43b96e44ab53fe3bc4216fe61116903ad427e4 Type: SHA-1 Checksum: 96bcbdf0122ac6605a0bdc77d7a87223c63ee7288a2afbad1a51ce0c5c0d3c83 Type: SHA-256