1063556a6fb1697ad83ea07d40c3074f euae272.pdf 2f16746aaa7cf15b3b0aa455a43214e4187c76d4 euae272.pdf d7ca61c0e981e3cfd80dc69f778dbb044d277931f7acf9a8dc4631790e81997b euae272.pdf Title: Drug therapy and catheter ablation for management of arrhythmias in continuous flow left ventricular assist device’s patients: a Clinical Consensus Statement of the European Heart Rhythm Association and the Heart Failure Association of the ESC Subject: DOI: 10.1093/europace/euae272; Europace, 2024-10-31.; Abstract: Left ventricular assist devices (LVADs) are an increasingly used strategy for the management of patients with advanced heart failure. Although these devices effectively improve survival, atrial and ventricular arrhythmias are common with a prevalence of 20–50% at one year after LVAD implantation. Arrhythmias predispose these patients to additional risk and are associated with considerable morbidity from recurrent implantable cardioverter-defibrillator shocks, progressive failure of the unsupported right ventricle, and herald an increased risk of mortality. Management of patients with arrhythmias and LVAD differs in many aspects from the general population heart failure patients. These include ruling out the reversible causes of arrhythmias that in LVAD patients may include mechanical irritation from the inflow cannula and suction events. For patients with symptomatic arrhythmias refractory to medical treatment, catheter ablation might be relevant. There are specific technical and procedural challenges perceived to be unique to LVAD-related ventricular tachycardia (VT) ablation such as vascular and LV access, signal filtering, catheter manoeuvrability within decompressed chambers, and electroanatomic mapping system interference. In some patients, the arrhythmogenic substrate might not be readily accessible by catheter ablation after LVAD implantation. In this regard, the peri-implantation period offers a unique opportunity to surgically address arrhythmogenic substrate and suppress future VT recurrences. This document aims to address specific aspects of the management of arrhythmias in LVAD patients focusing on anti-arrhythmic drug therapy and ablations. Keywords: Left ventricular assist device; Atrial fibrillation; Ventricular arrhythmia; Catheter ablation; Heart failure Author: Petr Peichl Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Thu May 22 04:00:08 2025 CEST ModDate: Thu May 22 09:52:27 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 9768847 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XKDHGB+GillSansNova-Book CID TrueType Identity-H yes yes yes 2163 0 QLUBQJ+GillSansNova-Bold CID TrueType Identity-H yes yes yes 2166 0 WKFQUN+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 2169 0 LRPDFW+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 2172 0 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Destination: seceuae272-s1 Item: Title: Aim of the paper Destination: seceuae272-s2 Item: Title: General considerations Destination: seceuae272-s3 Item: Title: Drug therapy for arrhythmias in LVAD patients Destination: seceuae272-s4 Children: Item: Title: HF guideline-directed medical therapy Destination: seceuae272-s4.1 Item: Title: AAD therapy Destination: seceuae272-s4.2 Item: Title: Atrial arrhythmias Destination: seceuae272-s4.3 Item: Title: Ventricular Arrhythmias Destination: seceuae272-s4.4 Item: Title: Amiodarone use in post-LVAD arrhythmias Destination: seceuae272-s4.5 Item: Title: Catheter ablation in LVAD recipients Destination: seceuae272-s5 Children: Item: Title: Catheter ablation of atrial arrhythmias Destination: seceuae272-s5.1 Item: Title: Catheter ablation of VAs prior to LVAD implantation Destination: seceuae272-s5.2 Item: Title: Peri-implantation surgical VAs ablation Destination: seceuae272-s5.3 Item: Title: Catheter ablation of VAs after LVAD implantation Destination: seceuae272-s5.4 Item: Title: Management of ES the role of drug therapy and catheter ablation Destination: seceuae272-s5.5 Item: Title: Procedural aspects of catheter ablation in LVAD patients Destination: seceuae272-s6 Children: Item: Title: Pre- and peri-procedural imaging Destination: seceuae272-s6.1 Item: Title: Signal filtering and the role of ECG in the location of the VT exit site Destination: seceuae272-s6.2 Item: Title: EMI and selection of mapping system Destination: seceuae272-s6.3 Item: Title: Mapping strategies and ablation targets Destination: seceuae272-s6.4 Item: Title: Complications of catheter ablation in LVAD patients Destination: seceuae272-s6.5 Item: Title: Vascular cannulation and access to cardiac chambers Destination: seceuae272-s6.6 Item: Title: Peri-procedural anticoagulation management Destination: seceuae272-s6.7 Item: Title: Peri-procedural haemodynamic monitoring Destination: seceuae272-s6.8 Item: Title: Gaps in knowledge Destination: seceuae272-s7 Item: Title: Conclusions Destination: seceuae272-s8 Item: Title: Acknowledgements Destination: acknow Item: Title: Reviewers Destination: seceuae272-s21.1 Item: Title: References Destination: reflist Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1167 ImageHeight: 509 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 811 ImageHeight: 456 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 868 ImageHeight: 376 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: XKDHGB+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: SLDREJ+GillSansNova-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: QLUBQJ+GillSansNova-Bold 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Martins Matteo Pagnesi Philippe Maury Mark C. Petrie Frederic Sacher Offer Amir DOI: 10.1093/europace/euae272; Europace, 2024-10-31.; Abstract: Left ventricular assist devices (LVADs) are an increasingly used strategy for the management of patients with advanced heart failure. Although these devices effectively improve survival, atrial and ventricular arrhythmias are common with a prevalence of 20–50% at one year after LVAD implantation. Arrhythmias predispose these patients to additional risk and are associated with considerable morbidity from recurrent implantable cardioverter-defibrillator shocks, progressive failure of the unsupported right ventricle, and herald an increased risk of mortality. Management of patients with arrhythmias and LVAD differs in many aspects from the general population heart failure patients. These include ruling out the reversible causes of arrhythmias that in LVAD patients may include mechanical irritation from the inflow cannula and suction events. For patients with symptomatic arrhythmias refractory to medical treatment, catheter ablation might be relevant. There are specific technical and procedural challenges perceived to be unique to LVAD-related ventricular tachycardia (VT) ablation such as vascular and LV access, signal filtering, catheter manoeuvrability within decompressed chambers, and electroanatomic mapping system interference. In some patients, the arrhythmogenic substrate might not be readily accessible by catheter ablation after LVAD implantation. In this regard, the peri-implantation period offers a unique opportunity to surgically address arrhythmogenic substrate and suppress future VT recurrences. This document aims to address specific aspects of the management of arrhythmias in LVAD patients focusing on anti-arrhythmic drug therapy and ablations. © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. Left ventricular assist device Atrial fibrillation Ventricular arrhythmia Catheter ablation Heart failure Journal Europace © The Author(s) 2024. 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