4c7d777eb6fbf8148ab452c9db0af33a jeae170.pdf e8c69ed98d790ba73cf1aa5466197024efedca95 jeae170.pdf d8ba8bfb312d6df5a6dfa2a2cdbac2ad47b65fc98de676645117d78355c67b51 jeae170.pdf Title: Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation Subject: DOI: 10.1093/ehjci/jeae170; European Heart Journal - Cardiovascular Imaging, 25, 12, 2024-07-10.; Abstract: Aims: To evaluate the prognostic implications of the left atrial reservoir strain–defined diastolic dysfunction (LARS-DD) grade in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and to determine whether post-TAVI LARS was more closely associated with new-onset atrial fibrillation than pre-TAVI LARS. Methods and results: Pre-TAVI LARS-DD was evaluated by speckle-tracking echocardiography and was assigned as Grade 0 to 1 (LARS ≥24%), Grade 2 (LARS 19–24%), and Grade 3 (LARS <19%). Patients were followed up for the primary endpoint of all-cause mortality from the date of TAVI. For the secondary endpoint, patients with pre- and post-TAVI LARS measurements and no history of atrial fibrillation were evaluated for the occurrence of new-onset atrial fibrillation. A total of 601 patients [median age 81 (76–85) years, 53% males] were i Keywords: left atrial strain; TAVI; aortic stenosis; diastolic dysfunction; outcome Author: Steele C. 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FontBBox: -504, -287, 1375, 966 FontFile2: true XMP: uuid:b24fef85-0561-4cac-b08e-a642a6ac957f uuid:28C57CA2-543C-1182-85A1-C30B0AC01FDC True left atrial strain; TAVI; aortic stenosis; diastolic dysfunction; outcome PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/ehjci/jeae170 en Oxford University Press Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation Steele C. Butcher Kensuke Hirasawa Maria Chiara Meucci Jan Stassen Jurrien H. Kuneman Ana Rita Pereira Frank van der Kley Arend de Weger Philippe J. van Rosendael Nina Ajmone Marsan David Playford Victoria Delgado Jeroen J. Bax DOI: 10.1093/ehjci/jeae170; European Heart Journal - Cardiovascular Imaging, 25, 12, 2024-07-10.; Abstract: Aims: To evaluate the prognostic implications of the left atrial reservoir strain–defined diastolic dysfunction (LARS-DD) grade in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and to determine whether post-TAVI LARS was more closely associated with new-onset atrial fibrillation than pre-TAVI LARS. Methods and results: Pre-TAVI LARS-DD was evaluated by speckle-tracking echocardiography and was assigned as Grade 0 to 1 (LARS ≥24%), Grade 2 (LARS 19–24%), and Grade 3 (LARS <19%). Patients were followed up for the primary endpoint of all-cause mortality from the date of TAVI. For the secondary endpoint, patients with pre- and post-TAVI LARS measurements and no history of atrial fibrillation were evaluated for the occurrence of new-onset atrial fibrillation. A total of 601 patients [median age 81 (76–85) years, 53% males] were i © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. left atrial strain TAVI aortic stenosis diastolic dysfunction outcome Journal European Heart Journal - Cardiovascular Imaging © The Author(s) 2024. 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