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Title:           First-in-class transactivator-free, doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B cell lymphomas
Subject:         Molecular Therapy: Nucleic Acid, 35 (2024) 102308. doi:10.1016/j.omtn.2024.102308
Author:          Pedro Justicia-Lirio
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        Title: Results
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          Title: Generation of transactivator-free, IL-18-inducible αCD19 CAR-T cells (iTRUCK19.18)
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          Title: Dox addition to iTRUCK19.18 cells enhanced their activation capacity without compromising T cell exhaustion and phenotype
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          Title: DOX regulates the antitumoral activity of iTRUCK19.18 cells in a Burkitt lymphoma model in vitro and in vivo
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          Title: Healthy donor and patient-derived iTRUCK19.18 cells show an increased antitumor potency against primary B-type tumors in th ...
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          Title: Dox treatment on iTRUCK19.18 cells increases their antitumoral potency against metastatic CD19+ PDAC model
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          Title: IL-18 induction allows the control of the polarization of pro-tumoral macrophages toward an antitumoral phenotype
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          Title: Flow cytometry
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          Title: IL-18 secretion assay
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   Type: CRC32
  Checksum: 50704e87109cfab2d01a1c22d40d222d
   Type: MD5
  Checksum: 650ce65f91f81d0de1e002d85778b0bf4033c023
   Type: SHA-1
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   Type: SHA-256