7b617237d88dbf9ec8ed5d5773a72b4c fimmu-15-1501872.pdf bfde50e1bca8c75eec15c6f1f66856cb298876c3 fimmu-15-1501872.pdf b8c4910471bb565bf570fc19f52528b14dac1a6a51a7c92327fcedc88724c02c fimmu-15-1501872.pdf Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 3959837 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OAONLL+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 781 0 OAONLM+AdvPSA18C Type 1C WinAnsi yes yes no 782 0 OAONLN+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 783 0 OAONLO+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 784 0 OAONLP+AdvPSA323 Type 1C WinAnsi yes yes no 785 0 OAONMA+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 791 0 OAONMB+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 792 0 OAONNB+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 793 0 OAOOIO+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 801 0 OAOOJO+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 804 0 OAOOMP+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 281 0 OAOONA+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 291 0 OAOOMO+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 287 0 OAOOOB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 292 0 OAOOPB+AdvOTd877c31c+21 Type 1C WinAnsi yes yes no 295 0 OAOOPC+AdvOTd877c31c Type 1C WinAnsi yes yes no 294 0 OBIEIN+AdvTT58d178b9+03 Type 1C Custom yes yes yes 335 0 OBIEIO+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 336 0 OBIEJP+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 337 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-04 02:10:08 CEST RepresentationInformation: fimmu-15-1501872.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-03 19:54:36 CEST Size: 3959837 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 865 FreeObjects: 4 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Prognostic performance of early immune and endothelial activation markers in mild-to-moderate COVID-19 outpatients: a nested case-control study Destination: bmark_422536354 Children: Item: Title: Introduction Destination: s1 Item: Title: Methods Destination: s2 Children: Item: Title: Study design Destination: s2_1 Item: Title: Study population Destination: s2_2 Item: Title: Clinical and laboratory evaluation Destination: s2_3 Item: Title: Study endpoints Destination: s2_4 Item: Title: Statistical methods Destination: s2_5 Item: Title: Results Destination: s3 Children: Item: Title: Study population characteristics Destination: s3_1 Item: Title: Selection of best discriminatory biomarkers for further exploration Destination: s3_2 Item: Title: Biomarkers as indicators of hospitalization and severe COVID-19 Destination: s3_3 Item: Title: Biomarker levels and kinetics by day 7 Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 ID: 0xd94b421930166d1fdf77acb5a80afd9b, 0x4c189cdcd65155479903535db90181c0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 6614 ImageHeight: 1250 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1291 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 969 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1292 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1292 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1291 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3544 ImageHeight: 1270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 969 ImageHeight: 638 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1027 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1027 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 712 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1027 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 712 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1027 ImageHeight: 712 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 712 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1027 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1026 ImageHeight: 711 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 4095 ImageHeight: 3544 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 4843 ImageHeight: 3525 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: OAOOIO+AdvTT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OAOOIO+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOONA+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OAOONA+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOOJO+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: OAOOJO+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOOOB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OAOOOB+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOOPC+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: OAOOPC+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOOPB+AdvOTd877c31c+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: OAOOPB+AdvOTd877c31c+21 Flags: Nonsymbolic FontBBox: -10, -250, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAONLL+AdvTTd3a5f740 FontSubset: true FirstChar: 37 LastChar: 241 FontDescriptor: FontName: OAONLL+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAONLM+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: OAONLM+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAONLN+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 241 FontDescriptor: FontName: OAONLN+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OBIEIN+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: OBIEIN+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OAONLO+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: OAONLO+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: OBIEIO+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OBIEIO+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OAONLP+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 184 FontDescriptor: FontName: OAONLP+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OBIEJP+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OBIEJP+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAONMA+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OAONMA+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAONMB+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OAONMB+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OAONNB+AdvOT3f84ef53 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: OAONNB+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OAOOMP+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OAOOMP+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OAOOMO+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: OAOOMO+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: Andrea Alemany Núria Balanza Pere Millat-Martinez Dan Ouchi Marc Corbacho-Monné Cristian Morales-Indiano Gema Fernández Rivas Ignacio Blanco Oriol Mitjà Ruth Aguilar Carlota Dobaño Quique Bassat Gemma Moncunill Bàrbara Baro COnV-ert BMK STUDY GROUP Alemany A, Balanza N, Millat-Martinez P, Ouchi D, Corbacho-Monné M, Morales-Indiano C, Fernández Rivas G, Blanco I, Mitjà O, Aguilar R, Dobaño C, Bassat Q, Moncunill G, Baro B and COnV-ert BMK STUDY GROUP (2024) Prognostic performance of early immune and endothelial activation markers in mild-to-moderate COVID-19 outpatients: a nested case-control study. Front. Immunol. 15:1501872. doi: 10.3389/fimmu.2024.1501872 Copyright © 2024 Alemany, Balanza, Millat-Martinez, Ouchi, Corbacho-Monné, Morales-Indiano, Fernández Rivas, Blanco, Mitjà, Aguilar, Dobaño, Bassat, Moncunill, Baro and COnV-ert BMK STUDY GROUP. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. biomarkers host response COVID-19 SARS-CoV-2 outpatients Prognostic performance of early immune and endothelial activation markers in mild-to-moderate COVID-19 outpatients: a nested case-control study biomarkers; host response; COVID-19; SARS-CoV-2; outpatients True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 536, 706 Annotation: Subtype: Link Rect: 221, 660, 457, 681 Annotation: Subtype: Link Rect: 221, 635, 511, 656 Annotation: Subtype: Link Rect: 221, 610, 542, 631 Annotation: Subtype: Link Rect: 221, 585, 492, 606 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 528, 142, 535 Annotation: Subtype: Link Rect: 49, 370, 158, 377 Annotation: Subtype: Link Rect: 49, 293, 195, 300 Annotation: Subtype: Link Rect: 450, 802, 506, 809 Annotation: Subtype: Link Rect: 466, 793, 528, 800 Annotation: Subtype: Link Rect: 446, 783, 539, 790 Annotation: Subtype: Link Rect: 49, 789, 233, 806 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 183, 501, 187, 510 Destination: 220 Annotation: Subtype: Link Rect: 213, 476, 217, 485 Destination: 220 Annotation: Subtype: Link Rect: 222, 476, 226, 485 Destination: 220 Annotation: Subtype: Link Rect: 250, 301, 254, 310 Destination: 220 Annotation: Subtype: Link Rect: 258, 301, 262, 310 Destination: 220 Annotation: Subtype: Link Rect: 90, 214, 94, 223 Destination: 220 Annotation: Subtype: Link Rect: 99, 214, 107, 223 Destination: 220 Annotation: Subtype: Link Rect: 52, 176, 60, 185 Destination: 220 Annotation: Subtype: Link Rect: 220, 151, 228, 160 Destination: 220 Annotation: Subtype: Link Rect: 307, 517, 316, 526 Destination: 220 Annotation: Subtype: Link Rect: 495, 442, 503, 451 Destination: 220 Annotation: Subtype: Link Rect: 428, 176, 436, 185 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 77, 343, 86, 352 Destination: 220 Annotation: Subtype: Link Rect: 382, 519, 390, 528 Destination: 220 Annotation: Subtype: Link Rect: 395, 519, 404, 528 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 198, 331, 206, 340 Destination: 220 Annotation: Subtype: Link Rect: 491, 581, 545, 590 Destination: 220 Annotation: Subtype: Link Rect: 304, 569, 338, 578 Destination: 220 Annotation: Subtype: Link Rect: 407, 544, 433, 553 Destination: 43 Annotation: Subtype: Link Rect: 440, 281, 470, 290 Destination: 51 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 159, 180, 187, 189 Destination: 51 Annotation: Subtype: Link Rect: 80, 105, 107, 114 Destination: 51 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 189, 577, 226, 586 Destination: 60 Annotation: Subtype: Link Rect: 470, 552, 506, 561 Destination: 60 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 108, 495, 207, 504 Destination: 220 Annotation: Subtype: Link Rect: 145, 433, 233, 442 Destination: 220 Annotation: Subtype: Link Rect: 236, 395, 290, 404 Destination: 220 Annotation: Subtype: Link Rect: 49, 383, 83, 392 Destination: 220 Annotation: Subtype: Link Rect: 85, 295, 115, 304 Destination: 100 Annotation: Subtype: Link Rect: 307, 533, 335, 542 Destination: 196 Annotation: Subtype: Link Rect: 339, 533, 423, 542 Destination: 220 Annotation: Subtype: Link Rect: 307, 383, 391, 392 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 265, 303, 273, 312 Destination: 220 Annotation: Subtype: Link Rect: 277, 303, 285, 312 Destination: 220 Annotation: Subtype: Link Rect: 132, 228, 140, 237 Destination: 220 Annotation: Subtype: Link Rect: 118, 216, 126, 225 Destination: 220 Annotation: Subtype: Link Rect: 130, 216, 139, 225 Destination: 220 Annotation: Subtype: Link Rect: 52, 166, 61, 175 Destination: 220 Annotation: Subtype: Link Rect: 155, 153, 163, 162 Destination: 220 Annotation: Subtype: Link Rect: 168, 153, 176, 162 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 96, 166, 104, 175 Destination: 220 Annotation: Subtype: Link Rect: 108, 166, 117, 175 Destination: 268 Annotation: Subtype: Link Rect: 131, 103, 139, 112 Destination: 268 Annotation: Subtype: Link Rect: 143, 103, 152, 112 Destination: 268 Annotation: Subtype: Link Rect: 156, 91, 164, 100 Destination: 268 Annotation: Subtype: Link Rect: 163, 375, 239, 382 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 351, 244, 456, 253 Destination: 220 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 315, 653, 545, 662 Annotation: Subtype: Link Rect: 304, 641, 403, 650 Annotation: Subtype: Link Rect: 86, 550, 226, 557 Annotation: Subtype: Link Rect: 62, 515, 142, 522 Annotation: Subtype: Link Rect: 185, 488, 237, 495 Annotation: Subtype: Link Rect: 75, 453, 168, 460 Annotation: Subtype: Link Rect: 216, 425, 267, 432 Annotation: Subtype: Link Rect: 62, 389, 113, 396 Annotation: Subtype: Link Rect: 266, 361, 290, 368 Annotation: Subtype: Link Rect: 49, 353, 133, 360 Annotation: Subtype: Link Rect: 179, 334, 259, 341 Annotation: Subtype: Link Rect: 186, 307, 262, 314 Annotation: Subtype: Link Rect: 62, 272, 137, 279 Annotation: Subtype: Link Rect: 107, 237, 161, 244 Annotation: Subtype: Link Rect: 262, 210, 290, 217 Annotation: Subtype: Link Rect: 49, 202, 107, 209 Annotation: Subtype: Link Rect: 146, 175, 224, 182 Annotation: Subtype: Link Rect: 201, 148, 290, 155 Annotation: Subtype: Link Rect: 264, 121, 290, 128 Annotation: Subtype: Link Rect: 49, 113, 97, 120 Annotation: Subtype: Link Rect: 266, 78, 290, 85 Annotation: Subtype: Link Rect: 49, 70, 81, 77 Annotation: Subtype: Link Rect: 425, 542, 516, 549 Annotation: Subtype: Link Rect: 317, 515, 408, 522 Annotation: Subtype: Link Rect: 459, 488, 537, 495 Annotation: Subtype: Link Rect: 432, 461, 515, 468 Annotation: Subtype: Link Rect: 317, 426, 394, 433 Annotation: Subtype: Link Rect: 402, 399, 449, 406 Annotation: Subtype: Link Rect: 522, 372, 545, 379 Annotation: Subtype: Link Rect: 304, 364, 358, 371 Annotation: Subtype: Link Rect: 444, 337, 523, 344 Annotation: Subtype: Link Rect: 317, 291, 408, 298 Annotation: Subtype: Link Rect: 474, 256, 525, 263 Annotation: Subtype: Link Rect: 408, 229, 489, 236 Annotation: Subtype: Link Rect: 370, 194, 422, 201 Annotation: Subtype: Link Rect: 317, 159, 401, 166 Annotation: Subtype: Link Rect: 469, 124, 521, 131 Annotation: Subtype: Link Rect: 433, 105, 476, 112 Annotation: Subtype: Link Rect: 500, 78, 545, 85 Annotation: Subtype: Link Rect: 304, 70, 339, 77 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 266, 742, 290, 749 Annotation: Subtype: Link Rect: 49, 734, 88, 741 Annotation: Subtype: Link Rect: 97, 696, 181, 703 Annotation: Subtype: Link Rect: 432, 742, 494, 749 Annotation: Subtype: Link Rect: 522, 723, 545, 730 Annotation: Subtype: Link Rect: 304, 715, 361, 722 Annotation: Subtype: Link Rect: 385, 696, 458, 703 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 876e8e84 Type: CRC32 Checksum: 7b617237d88dbf9ec8ed5d5773a72b4c Type: MD5 Checksum: bfde50e1bca8c75eec15c6f1f66856cb298876c3 Type: SHA-1 Checksum: b8c4910471bb565bf570fc19f52528b14dac1a6a51a7c92327fcedc88724c02c Type: SHA-256