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Immunol. 15:1465159 Keywords: common variable immunodeficiency, immune dysregulation, malignancy, cancer risk, immunosuppressants Author: Marta Dafne Cabañero-Navalon CreationDate: Fri Oct 11 10:24:55 2024 CEST ModDate: Fri Oct 11 10:24:55 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 596705 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LADLAI+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 593 0 LADLAJ+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 594 0 LADLAK+AdvPSA18C Type 1C WinAnsi yes yes no 595 0 LADLBK+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 596 0 LADLBL+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 597 0 LADLBM+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 598 0 LADLBN+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 599 0 LADLBO+AdvPSA323 Type 1C WinAnsi yes yes no 614 0 LADLBP+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 615 0 LADMEJ+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 619 0 LADMEK+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 620 0 LADMIJ+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 186 0 LADMIK+AdvOT1ef757c0 Type 1C Custom yes yes yes 183 0 LADMIL+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 177 0 LADMIM+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 176 0 LADMKM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 187 0 LADMNM+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 192 0 LAEBAC+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 194 0 LAEBAD+AdvOT94be8fa4.B Type 1C WinAnsi yes yes no 198 0 LAEBAE+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 195 0 LAEHDM+AdvTT58d178b9+03 Type 1C Custom yes yes yes 201 0 LAEHDN+AdvOT1ef757c0+01 Type 1C Custom yes yes no 202 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-14 02:41:25 CEST RepresentationInformation: fimmu-15-1465159.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-13 14:08:00 CEST Size: 596705 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 678 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study Destination: bmark_-128263405 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Study design, setting and population Destination: s2_1 Item: Title: 2.2 Data collection and variables Destination: s2_2 Item: Title: 2.3 Definitions Destination: s2_3 Item: Title: 2.4 Statistical analysis Destination: s2_4 Item: Title: 2.5 Ethical statement Destination: s2_5 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Study population Destination: s3_1 Item: Title: 3.2 Multivariable regression analysis Destination: s3_2 Item: Title: 4 Discussion Destination: s4 Item: Title: 5 Conclusion Destination: s5 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Title: The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study Author: Marta Dafne Cabañero-Navalon Subject: Cabañero-Navalon MD, Garcia-Bustos V, Balastegui-Martin H, Bracke C, Mateu L, Solanich X, Carrillo-Linares JL, Robles-Marhuenda A, Puchades F, Pelaez Ballesta A, Lopez-Osle N, Torralba-Cabeza MÁ, Bielsa Masdeu AM, Gil Niño J, Tornador Gaya N, Castellanos GP, Sánchez-Martínez R, Barragán-Casas JM, González-García A, Patier de la Peña JL, López-Wolf D, Rufete AM, Canovas Mora A and Moral Moral P (2024) The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study. 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FontDescriptor: FontName: LADMKM+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf Marta Dafne Cabañero-Navalon Victor Garcia-Bustos Héctor Balastegui-Martin Carmen Bracke Lourdes Mateu Xavier Solanich Juan Luis Carrillo-Linares Angel Robles-Marhuenda Francesc Puchades Ana Pelaez Ballesta Nuria Lopez-Osle Miguel Ángel Torralba-Cabeza Ana María Bielsa Masdeu Jorge Gil Niño Nuria Tornador Gaya Guillem Pascual Castellanos Rosario Sánchez-Martínez José Manuel Barragán-Casas Andrés González-García José Luis Patier de la Peña Daniel López-Wolf Antonia Mora Rufete Alba Canovas Mora Pedro Moral Moral Cabañero-Navalon MD, Garcia-Bustos V, Balastegui-Martin H, Bracke C, Mateu L, Solanich X, Carrillo-Linares JL, Robles-Marhuenda A, Puchades F, Pelaez Ballesta A, Lopez-Osle N, Torralba-Cabeza MÁ, Bielsa Masdeu AM, Gil Niño J, Tornador Gaya N, Castellanos GP, Sánchez-Martínez R, Barragán-Casas JM, González-García A, Patier de la Peña JL, López-Wolf D, Rufete AM, Canovas Mora A and Moral Moral P (2024) The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study. Front. Immunol. 15:1465159 Copyright © 2024 Cabañero-Navalon, Garcia-Bustos, Balastegui-Martin, Bracke, Mateu, Solanich, Carrillo-Linares, Robles-Marhuenda, Puchades, Pelaez Ballesta, Lopez-Osle, Torralba-Cabeza, Bielsa Masdeu, Gil Niño, Tornador Gaya, Castellanos, Sánchez-Martínez, Barragán-Casas, González-García, Patier de la Peña, López-Wolf, Rufete, Canovas Mora and Moral Moral. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 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