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Keywords: alemtuzumab, multiple sclerosis, tumefactive demyelinating lesions, rebound, immune subpopulations, biomarkers, case report Author: Neus Rabaneda-Lombarte CreationDate: Mon Jul 1 05:30:58 2024 CEST ModDate: Mon Jul 1 05:30:58 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 10990454 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LIOKOC+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 222 0 LIOKOD+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 223 0 LIOKOE+AdvPSA18C Type 1C WinAnsi yes yes no 224 0 LIOKOF+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 225 0 LIOKOG+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 226 0 LIOKOH+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 227 0 LIOKOI+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 228 0 LIOLME+AdvPSA323 Type 1C WinAnsi yes yes no 243 0 LIOLMF+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 244 0 LIOLMG+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 245 0 LIOLOH+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 113 0 LIOLOI+AdvOTd877c31c Type 1C WinAnsi yes yes no 109 0 LIOLOJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 111 0 LIOLOG+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 115 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 122 0 LIPPEM+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 126 0 LIPPFM+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 127 0 LIPPFN+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 128 0 LIPPFO+AdvOT1ef757c0+01 Type 1C Custom yes yes no 129 0 LIPPFP+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 130 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-18 02:41:31 CEST RepresentationInformation: 311551.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-17 11:10:14 CEST Size: 10990454 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 293 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Case report: tumefactive demyelinating lesions after the second cycle of alemtuzumab in multiple sclerosis; immune cell profile and biomarkers Destination: bmark_-1792962700 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Case description Destination: s2 Item: Title: 3 Discussion Destination: s3 Item: Title: Data availability statement Destination: s4 Item: Title: Ethics statement Destination: s5 Item: Title: Author contributions Destination: s6 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Title: Case report: tumefactive demyelinating lesions after the second cycle of alemtuzumab in multiple sclerosis; immune cell profile and biomarkers Author: Neus Rabaneda-Lombarte Subject: Objective: We present a case of multiple tumefactive demyelinating lesions (TDLs) emerging 24 months after the second cycle of alemtuzumab treatment. 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FontDescriptor: FontName: LIPPEM+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LIOKOD+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LIOKOD+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LIPPFM+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: LIPPFM+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf Neus Rabaneda-Lombarte Aina Teniente-Serra Anna Massuet-Vilamajó Cristina Ramo-Tello Silvia Presas-Rodríguez Objective: We present a case of multiple tumefactive demyelinating lesions (TDLs) emerging 24 months after the second cycle of alemtuzumab treatment. Copyright © 2024 Rabaneda-Lombarte, Teniente-Serra, Massuet-Vilamajó, Ramo-Tello and Presas-Rodríguez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 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