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Destination: s2_2 Item: Title: 2.3 Analyses of adverse events by baseline and on-treatment CD4+ T-cell count Destination: s2_3 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Participants Destination: s3_1 Item: Title: 3.2 Analysis of adverse events through week 192 by baseline and on-treatment CD4+ T-cell count Destination: s3_2 Children: Item: Title: 3.2.1 Pilot assessment Destination: s3_2_1 Item: Title: 3.2.2 Exposure-adjusted adverse event assessment Destination: s3_2_2 Item: Title: 3.3 Cumulative safety through week 240 Destination: s3_3 Children: Item: Title: 3.3.1 QTc prolongation Destination: s3_3_1 Item: Title: 3.3.2 Immune reconstitution inflammatory syndrome Destination: s3_3_2 Item: Title: 3.3.3 Laboratory abnormalities Destination: s3_3_3 Item: Title: 3.3.4 Pregnancies Destination: s3_3_4 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author 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Llibre Judith A. Aberg Sharon Walmsley Juan Velez Carlos Zala Brenda Crabtree Ramírez Bronagh Shepherd Rimi Shah Andrew Clark Allan R. Tenorio Amy Pierce Fangfang Du Bo Li Marcia Wang Shiven Chabria Michael Warwick-Sanders Llibre JM, Aberg JA, Walmsley S, Velez J, Zala C, Crabtree Ramírez B, Shepherd B, Shah R, Clark A, Tenorio AR, Pierce A, Du F, Li B, Wang M, Chabria S and Warwick-Sanders M (2024) Long-term safety and impact of immune recovery in heavily treatment-experienced adults receiving fostemsavir for up to 5 years in the phase 3 BRIGHTE study. Front. Immunol. 15:1394644 Copyright © 2024 Llibre, Aberg, Walmsley, Velez, Zala, Crabtree Ramírez, Shepherd, Shah, Clark, Tenorio, Pierce, Du, Li, Wang, Chabria and Warwick-Sanders. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ARV clinical trials drug resistance intervention treatment Long-term safety and impact of immune recovery in heavily treatment-experienced adults receiving fostemsavir for up to 5 years in the phase 3 BRIGHTE study ARV, clinical trials, drug resistance, intervention, treatment True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 530, 706 Annotation: Subtype: Link Rect: 221, 660, 488, 681 Annotation: Subtype: Link Rect: 221, 635, 510, 656 Annotation: Subtype: Link Rect: 221, 610, 498, 631 Annotation: Subtype: Link Rect: 221, 585, 459, 606 Annotation: Subtype: Link Rect: 221, 560, 368, 581 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 546, 142, 553 Annotation: Subtype: Link Rect: 49, 536, 108, 543 Annotation: Subtype: Link Rect: 49, 388, 159, 395 Annotation: Subtype: Link 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