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Title:           VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice
Subject:         Vaccine, 42 (2024) 3474-3485. doi:10.1016/j.vaccine.2024.04.048
Keywords:        Respiratory syncytial virus,Human metapneumovirus,Vaccine,HIV Gag,Fusion protein,Virus like particles,Immunogenicity,Neutralizing antibodies
Author:          Benjamin Trinité
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      Title: VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing respo ...
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        Title: 1 Introduction
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        Title: 2 Results
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          Title: 2.1 RSV-F vaccine strategy
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          Title: 2.2 mVRC4-Gag and VLPVRC4 antigenicity
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          Title: 2.3 VLPVRC4 purification and quantification
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          Title: 2.4 VRC4 immunization in BALB/c mice
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          Title: 2.5 hMPV-F VLP vaccine
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          Title: 2.6 Homologous and heterologous VRC4 and hMPV-F immunization in C57Bl/6JOlaHsd mice
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        Title: 3 Discussion
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        Title: 4 Methods
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          Title: 4.1 Antibodies
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          Title: 4.2 Soluble VRC4 and hMPV-F proteins
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          Title: 4.6 Flow cytometry analysis of antigenicity
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          Title: 4.7 Transmission electron microscopy (TEM)
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          Title: 4.8 VLP extraction
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          Title: 4.9 ELISA analysis of antigenicity
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          Title: 4.10 Cryogenic transmission electron microscopy (cryo-EM)
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          Title: 4.11 VLP purification
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          Title: 4.12 Coomassie and western blot characterization
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          Title: 4.16 Mouse immunogenicity studies
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          Title: 4.17 Immunogenicity analysis
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          Title: 4.18 Neutralizing response analysis
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          Title: 4.19 Statistical analysis
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          Title: CRediT authorship contribution statement
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        Title: Declaration of competing interest
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        Title: Data availability
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        Title: Acknowledgements
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        Title: Appendix A Supplementary material
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   Type: CRC32
  Checksum: 8878e957acb7bb4fc16abb7ea751995e
   Type: MD5
  Checksum: 8d386b0116e35d7f29d9ccc36b1606fb443d3abd
   Type: SHA-1
  Checksum: 7e19bccbef00671ee17567e867db1e3ac94cf16028974f672e232f5615e6661a
   Type: SHA-256