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Destination: titlink1 Children: Item: Title: 1 Introduction Destination: flink1 Item: Title: 2 Materials and methods Destination: flink2 Children: Item: Title: 2.1 Cell lines Destination: slink1 Item: Title: 2.2 Drugs Destination: slink2 Item: Title: 2.3 Cell viability assay Destination: slink3 Item: Title: 2.4 Colony assay Destination: slink4 Item: Title: 2.5 Western blot assay Destination: slink5 Item: Title: 2.6 Apoptosis assay Destination: slink6 Item: Title: 2.7 Dynamic BH3 profiling (DBP) assay Destination: slink7 Item: Title: 2.8 PTEN-knockdown with CRISPR/Cas9 Destination: slink8 Item: Title: 2.9 Preclinical assays in vivo Destination: slink9 Item: Title: 2.10 Statistical analysis Destination: slink10 Item: Title: 3 Results Destination: flink3 Children: Item: Title: 3.1 PI3K/AKT and MEK/ERK pathways are hyperactivated in docetaxel-resistant mCRPC cells Destination: slink11 Item: Title: 3.2 Combination treatment with selumetinib+AZD8186 synergistically decreased cell viability and induced apoptosis in PTEN-w ... Destination: slink12 Item: Title: 3.3 Selumetinib+AZD8186 reduces tumor growth in PTEN-wt docetaxel-resistant xenograft mouse models Destination: slink13 Item: Title: 4 Discussion Destination: flink4 Item: Title: 5 Conclusion Destination: flink5 Item: Title: Data availability statement Destination: flink6 Item: Title: Ethics statement Destination: flink7 Item: Title: Author contributions Destination: flink8 Item: Title: Funding Destination: flink9 Item: Title: Acknowledgments Destination: slink14 Item: Title: Conflict of interest Destination: flink10 Item: Title: Publisher’s note Destination: flink11 Item: Title: Supplementary material Destination: flink12 Item: Title: References Destination: rlink1 Info: Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Jan 17 16:53:05 CET 2024 ModDate: Wed Jan 17 16:53:05 CET 2024 ID: 0x4754c25c787641cad76c9fe71d94a3f0, 0x02ac38d7bf41f0449760170956a0a06f Filters: FilterPipeline: 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