c96396b4f21f438114ac0acef2b82d64 s00415-024-12518-7.pdf 14eb1f3ea1be6ba8ba72c1c5676aea35ad2046b5 s00415-024-12518-7.pdf 0031ca09e077692a661fd7c59270b54a3954aa93fc76f4682850b75cff9856f5 s00415-024-12518-7.pdf Title: A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic Subject: Journal of Neurology, https://doi.org/10.1007/s00415-024-12518-7 Keywords: Multiple sclerosis; COVID-19; Disease-modifying therapy; Anti-CD20 monoclonal antibodies; Cladribine; Natalizumab Author: Anoushka P. Lal Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Wed Jun 26 10:33:08 2024 CEST ModDate: Wed Aug 28 14:22:48 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 615178 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 283 0 MyriadPro-Semibold Type 1C Custom yes no yes 284 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 285 0 MyriadPro-SemiboldIt Type 1C WinAnsi yes no yes 286 0 MyriadPro-Bold Type 1C Custom yes no yes 287 0 UANVVP+STIX-Regular Type 1C Custom yes yes yes 288 0 DKHHCJ+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 324 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 138 0 DSVBJM+STIX-Italic Type 1C WinAnsi yes yes yes 181 0 JUESBX+STIX-Bold Type 1C WinAnsi yes yes yes 221 0 OBVHPB+Helvetica Type 1C WinAnsi yes yes no 222 0 Helvetica2 Type 1C Custom yes no no 223 0 Helvetica3 Type 1C Custom yes no no 224 0 OBVHPB+Arial-BoldMT Type 1C WinAnsi yes yes no 225 0 GWUHXU+Wingdings-Regular Type 1C WinAnsi yes yes yes 232 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-14 02:41:18 CEST RepresentationInformation: s00415-024-12518-7.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-13 15:31:22 CEST Size: 615178 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 371 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Results Item: Title: Conclusions Item: Title: Background Item: Title: Methods Children: Item: Title: Participant selection and patient consent Item: Title: Study participants Item: Title: Outcomes and definitions Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Participant demographics Item: Title: Comparison of high- and low-efficacy DMT prescription pre- and post-pandemic onset Item: Title: Analysis of DMT prescribing patterns pre- and post-pandemic onset Item: Title: Discussion Item: Title: Appendix 1 Item: Title: References Info: Title: A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic Author: Anoushka P. Lal Subject: Journal of Neurology, https://doi.org/10.1007/s00415-024-12518-7 Keywords: Multiple sclerosis; COVID-19; Disease-modifying therapy; Anti-CD20 monoclonal antibodies; Cladribine; Natalizumab Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Wed Jun 26 11:03:08 CEST 2024 ModDate: Wed Aug 28 14:52:48 CEST 2024 ID: 0xf2ed8205375af94795a7a20bb3c6ed5f, 0xd4539d6bf81ca94598b096a7c8714ccf Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: UANVVP+STIX-Regular FontSubset: true FirstChar: 24 LastChar: 250 FontDescriptor: FontName: UANVVP+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Helvetica3 FirstChar: 31 LastChar: 122 FontDescriptor: FontName: Helvetica3 Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBVHPB+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 98 FontDescriptor: FontName: OBVHPB+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GWUHXU+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GWUHXU+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DSVBJM+STIX-Italic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: DSVBJM+STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JUESBX+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: JUESBX+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OBVHPB+Helvetica FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OBVHPB+Helvetica Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Helvetica2 FirstChar: 31 LastChar: 122 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2024-06-26T14:03:08+05:30 Springer 2024-08-28T17:52:48+05:30 2024-08-28T17:52:48+05:30 Acrobat Distiller 10.1.8 (Windows) Multiple sclerosis; COVID-19; Disease-modifying therapy; Anti-CD20 monoclonal antibodies; Cladribine; Natalizumab application/pdf https://doi.org/10.1007/s00415-024-12518-7 Springer Berlin Heidelberg Journal of Neurology, https://doi.org/10.1007/s00415-024-12518-7 Multiple sclerosis COVID-19 Disease-modifying therapy Anti-CD20 monoclonal antibodies Cladribine Natalizumab A multi-centre longitudinal study analysing multiple sclerosis disease-modifying therapy prescribing patterns during the COVID-19 pandemic Anoushka P. Lal Yi Chao Foong Paul G. Sanfilippo Tim Spelman Louise Rath David Levitz Marzena Fabis-Pedrini Matteo Foschi Mario Habek Tomas Kalincik Izanne Roos Jeannette Lechner-Scott Nevin John Aysun Soysal Emanuele D’Amico Riadh Gouider Saloua Mrabet Katrin Gross-Paju Simón Cárdenas-Robledo Abdorreza Naser Moghadasi Maria Jose Sa Orla Gray Jiwon Oh Stephen Reddel Sudarshini Ramanathan Talal Al-Harbi Ayse Altintas Todd A. Hardy Serkan Ozakbas Raed Alroughani Allan G. Kermode Andrea Surcinelli Guy Laureys Sara Eichau Alexandre Prat Marc Girard Pierre Duquette Suzanne Hodgkinson Cristina Ramo-Tello Davide Maimone Pamela McCombe Daniele Spitaleri Jose Luis Sanchez-Menoyo Mehmet Fatih Yetkin Seyed Mohammad Baghbanian Rana Karabudak Abdullah Al-Asmi Gregor Brecl Jakob Samia J. Khoury Masoud Etemadifar Vincent van Pesch Katherine Buzzard Bruce Taylor Helmut Butzkueven Anneke Van der Walt 10.1007/s00415-024-12518-7 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00415-024-12518-7 10.1007/s00415-024-12518-7 1432-1459 271 9 5813 5824 journal Journal of Neurology The Author(s) 2010-04-23 true 10.1007/s00415-024-12518-7 noindex springer.com springerlink.com VoR uuid:639bd118-115d-4e5f-9de4-08514ad9be93 uuid:c691fce0-bd1e-4fc2-a84c-a17108140500 default 1 converted uuid:06024d04-5576-4620-9c60-4f6b0d1455da converted to PDF/A-2b pdfToolbox 2024-08-28T17:52:14+05:30 converted uuid:ccbbce19-8e0f-4cbd-a99c-e35b30eaff82 converted to PDF/A-2b pdfToolbox 2024-08-28T17:52:48+05:30 2 B Anneke Van der Walt http://orcid.org/0000-0002-4278-7003 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. 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