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Title:           Combination of gallium citrate and levofloxacin induces a distinct metabolome profile and enhances growth inhibition of multidrug-resistant Mycobacterium tuberculosis compared to linezolid
Subject:         Ilchenko O, Nikolaevskaya E, Zinchenko O, Ivanytsia V, Prat-Aymerich C, Ramstedt M and Rzhepishevska O (2024) Combination of gallium citrate and levofloxacin induces a distinct metabolome profile and enhances growth inhibition of multidrug-resistant Mycobacterium tuberculosis compared to linezolid. Front. Microbiol. 15:1474071. doi: 10.3389/fmicb.2024.1474071
Author:          Oleksandr Ilchenko
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     Item: 
      Title: Combination of gallium citrate and levofloxacin induces a distinct metabolome profile and enhances growth inhibition of multidrug-resistant Mycobacterium tuberculosis compared to linezolid
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Strains and growth conditions
         Item: 
          Title: Whole genome sequencing and drug resistance mapping
         Item: 
          Title: Growth inhibition assay
         Item: 
          Title: Gas chromatography–mass spectrometry
         Item: 
          Title: Liquid chromatography-mass spectrometry
         Item: 
          Title: Data analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Drug resistance profile of the Mtb strain used in the growth inhibition assay
         Item: 
          Title: Minimal inhibitory concentration of Ga in MGIT™ media
         Item: 
          Title: A combination of Ga with Lfx results in stronger growth inhibition of Mtb
         Item: 
          Title: The metabolite profile of Mtb cells grown in the presence of Ga is concentration dependent
         Item: 
          Title: Cells grown with Ga alone and Ga/Lfx display a similar metabolite pattern at 500 μM
         Item: 
          Title: Additional metabolites associated with Ga and Lfx exposure measured by LC–MS
       Item: 
        Title: Discussion
     Item: 
      Title: References
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  Checksum: 25fac8a9
   Type: CRC32
  Checksum: de1e472e67dceb516cb08abd48b49e75
   Type: MD5
  Checksum: 52675e277e84df94c0216e04fd0485e505f6bed9
   Type: SHA-1
  Checksum: 552c5f872e86def3da0cd2e1ac2edee52f9b319c11d8ccf9f26df11e220ec818
   Type: SHA-256