64cb31481e8ab9dcea49df695cf9eab0 fmicb-15-1478263.pdf d2dd812d26b2c8fa42e0904304d7ea22084cae1c fmicb-15-1478263.pdf b6b199012973083503ff524c1ae9b0298da213992aa5c410d5bae16bba41874f fmicb-15-1478263.pdf Title: Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach Subject: Vidal M, Arch M, Fuentes E and Cardona P-J (2024) Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach. Front. Microbiol. 15:1478263. doi: 10.3389/fmicb.2024.1478263 Author: Maria Vidal Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sat Nov 2 08:28:40 2024 CET ModDate: Sat Nov 2 08:29:03 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1330769 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PBYOSP+MuseoSans-500 Type 1C Custom yes yes yes 8 0 NYZCQT+MuseoSans-500Italic Type 1C WinAnsi yes yes yes 11 0 MUKWCV+MuseoSans-300 Type 1C Custom yes yes yes 12 0 KRLKAZ+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 109 0 JSWEMB+MuseoSans-700 Type 1C Custom yes yes yes 108 0 IOMYYD+MuseoSans-700Italic Type 1C WinAnsi yes yes yes 138 0 HPXSKF+MinionPro-Regular Type 1C Custom yes yes yes 9 0 DEZUGN+MinionPro-It Type 1C Custom yes yes yes 10 0 BBVIER+STIXGeneral-Regular Type 1C Custom yes yes yes 51 0 ZYWWCV+STIXGeneral-Italic Type 1C Custom yes yes yes 52 0 ZYWWCV+STIX-Regular Type 1C Custom yes yes yes 53 0 XVXKAZ+MinionPro-Bold Type 1C WinAnsi yes yes yes 54 0 WWIEMB+GentiumPlus CID TrueType Identity-H yes yes yes 348 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-21 02:43:45 CEST RepresentationInformation: fmicb-15-1478263.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-20 14:45:27 CEST Size: 1330769 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2945 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach Children: Item: Title: 1 Introduction Item: Title: 2 Drosophila melanogaster as a good model for the screening of drugs against infections Children: Item: Title: 2.1 Drosophila melanogaster compared with other cost-effective animal models: Caenorhabditis elegans and Galleria mellonella Item: Title: 3 How to treat Drosophila melanogaster Children: Item: Title: 3.1 Oral treatment of adult flies Item: Title: 3.1.1 Methodologies to control Drosophila melanogaster food consumption Item: Title: 3.1.2 Proper drug concentrations for infectious disease treatment in Drosophila melanogaster Item: Title: 3.2 Other treatment strategies Item: Title: 3.2.1 Aerosol administration Item: Title: 3.2.2 Nano-injection administration Item: Title: 4 How to monitor the treatment of infectious diseases in Drosophila melanogaster Children: Item: Title: 4.1 Survival Item: Title: 4.2 Pathogen load Item: Title: 4.3 Immune response gene expression Item: Title: 5 Cost-effectiveness of a treatment study in Drosophila melanogaster Item: Title: 6 Technical considerations and limitations of the model Item: Title: 7 Discussion Item: Title: References Info: Title: Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach Author: Maria Vidal Subject: Vidal M, Arch M, Fuentes E and Cardona P-J (2024) Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach. Front. Microbiol. 15:1478263. doi: 10.3389/fmicb.2024.1478263 Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sat Nov 02 08:58:40 CET 2024 ModDate: Sat Nov 02 08:59:03 CET 2024 ID: 0x28a1f6f865ce244c8a6b335af2717c7b, 0x806709ecc86ba163fbd6ec14e37a2708 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2852 ImageHeight: 1472 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2861 ImageHeight: 1488 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: WWIEMB+GentiumPlus Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BBVIER+STIXGeneral-Regular FontSubset: true FirstChar: 28 LastChar: 31 FontDescriptor: FontName: BBVIER+STIXGeneral-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZYWWCV+STIXGeneral-Italic FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: ZYWWCV+STIXGeneral-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZYWWCV+STIX-Regular FontSubset: true FirstChar: 30 LastChar: 176 FontDescriptor: FontName: ZYWWCV+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XVXKAZ+MinionPro-Bold FontSubset: true FirstChar: 44 LastChar: 44 FontDescriptor: FontName: XVXKAZ+MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: PBYOSP+MuseoSans-500 FontSubset: true FirstChar: 29 LastChar: 150 FontDescriptor: FontName: PBYOSP+MuseoSans-500 Flags: Nonsymbolic FontBBox: -121, -210, 1088, 892 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HPXSKF+MinionPro-Regular FontSubset: true FirstChar: 20 LastChar: 250 FontDescriptor: FontName: HPXSKF+MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IOMYYD+MuseoSans-700Italic FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: IOMYYD+MuseoSans-700Italic Flags: Nonsymbolic FontBBox: -254, -210, 1112, 902 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: DEZUGN+MinionPro-It FontSubset: true FirstChar: 31 LastChar: 122 FontDescriptor: FontName: DEZUGN+MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NYZCQT+MuseoSans-500Italic FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: NYZCQT+MuseoSans-500Italic Flags: Nonsymbolic FontBBox: -249, -210, 1047, 892 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JSWEMB+MuseoSans-700 FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: JSWEMB+MuseoSans-700 Flags: Nonsymbolic FontBBox: -125, -210, 1126, 902 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MUKWCV+MuseoSans-300 FontSubset: true FirstChar: 29 LastChar: 243 FontDescriptor: FontName: MUKWCV+MuseoSans-300 Flags: Nonsymbolic FontBBox: -118, -210, 1088, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KRLKAZ+MuseoSans-300Italic FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: KRLKAZ+MuseoSans-300Italic Flags: Nonsymbolic FontBBox: -245, -210, 1030, 883 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: WWIEMB+GentiumPlus CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WWIEMB+GentiumPlus Flags: Serif, Symbolic FontBBox: -677, -464, 1500, 1270 FontFile2: true XMP: Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach Maria Vidal Marta Arch Esther Fuentes Pere-Joan Cardona Vidal M, Arch M, Fuentes E and Cardona P-J (2024) Drosophila melanogaster experimental model to test new antimicrobials: a methodological approach. Front. Microbiol. 15:1478263. doi: 10.3389/fmicb.2024.1478263 Drosophila melanogaster antimicrobials resistance screening 3R policy innate immunity host-directed therapies preclinical Copyright © 2024 Vidal, Arch, Fuentes and Cardona. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 47, 808, 236, 790 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 47, 717, 223, 699 Annotation: Subtype: Link Rect: 221, 720, 465, 696 Annotation: Subtype: Link Rect: 221, 695, 529, 671 Annotation: Subtype: Link Rect: 221, 670, 539, 646 Annotation: Subtype: Link Rect: 221, 645, 312, 621 Annotation: Subtype: Link Rect: 522, 150, 545, 138 ActionDest: 527 Annotation: Subtype: Link Rect: 221, 138, 530, 126 ActionDest: 527 Annotation: Subtype: Link Rect: 474, 114, 540, 102 ActionDest: 592 Annotation: Subtype: Link Rect: 517, 102, 545, 90 ActionDest: 592 Annotation: Subtype: Link Rect: 221, 90, 238, 78 ActionDest: 592 Annotation: Subtype: Link Rect: 56, 558, 130, 551 Annotation: Subtype: Link Rect: 49, 458, 156, 450 Annotation: Subtype: Link Rect: 123, 417, 187, 409 Annotation: Subtype: Link Rect: 49, 408, 135, 400 Annotation: Subtype: Link Rect: 440, 807, 479, 800 Annotation: Subtype: Link Rect: 440, 798, 537, 791 Annotation: Subtype: Link Rect: 440, 789, 547, 782 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 233, 642, 285, 630 ActionDest: 592 Annotation: Subtype: Link Rect: 257, 606, 290, 594 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 594, 110, 582 ActionDest: 527 Annotation: Subtype: Link Rect: 112, 534, 115, 522 ActionDest: 3 Annotation: Subtype: Link Rect: 214, 474, 273, 462 ActionDest: 497 Annotation: Subtype: Link Rect: 277, 474, 290, 462 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 462, 87, 450 ActionDest: 592 Annotation: Subtype: Link Rect: 146, 426, 237, 414 ActionDest: 592 Annotation: Subtype: Link Rect: 241, 426, 290, 414 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 414, 66, 402 ActionDest: 592 Annotation: Subtype: Link Rect: 276, 186, 290, 174 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 174, 88, 162 ActionDest: 592 Annotation: Subtype: Link Rect: 59, 76, 177, 68 Annotation: Subtype: Link Rect: 348, 726, 422, 714 ActionDest: 592 Annotation: Subtype: Link Rect: 426, 726, 496, 714 ActionDest: 592 Annotation: Subtype: Link Rect: 372, 642, 438, 630 ActionDest: 527 Annotation: Subtype: Link Rect: 469, 618, 540, 606 ActionDest: 592 Annotation: Subtype: Link Rect: 389, 570, 460, 558 ActionDest: 527 Annotation: Subtype: Link Rect: 465, 570, 543, 558 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 558, 382, 546 ActionDest: 527 Annotation: Subtype: Link Rect: 386, 558, 440, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 477, 474, 543, 462 ActionDest: 497 Annotation: Subtype: Link Rect: 304, 462, 363, 450 ActionDest: 497 Annotation: Subtype: Link Rect: 368, 462, 422, 450 ActionDest: 592 Annotation: Subtype: Link Rect: 497, 318, 545, 306 ActionDest: 497 Annotation: Subtype: Link Rect: 304, 306, 321, 294 ActionDest: 497 Annotation: Subtype: Link Rect: 348, 222, 412, 210 ActionDest: 592 Annotation: Subtype: Link Rect: 453, 174, 523, 162 ActionDest: 592 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 52, 762, 146, 750 ActionDest: 592 Annotation: Subtype: Link Rect: 151, 762, 221, 750 ActionDest: 592 Annotation: Subtype: Link Rect: 226, 762, 256, 750 ActionDest: 592 Annotation: Subtype: Link Rect: 261, 762, 290, 750 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 750, 86, 738 ActionDest: 592 Annotation: Subtype: Link Rect: 90, 750, 143, 738 ActionDest: 592 Annotation: Subtype: Link Rect: 88, 570, 193, 558 ActionDest: 527 Annotation: Subtype: Link Rect: 197, 570, 288, 558 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 558, 170, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 173, 558, 225, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 229, 558, 290, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 546, 66, 534 ActionDest: 592 Annotation: Subtype: Link Rect: 208, 474, 290, 462 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 462, 66, 450 ActionDest: 527 Annotation: Subtype: Link Rect: 260, 414, 290, 402 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 402, 137, 390 ActionDest: 592 Annotation: Subtype: Link Rect: 173, 354, 238, 342 ActionDest: 527 Annotation: Subtype: Link Rect: 52, 294, 149, 282 ActionDest: 592 Annotation: Subtype: Link Rect: 155, 294, 219, 282 ActionDest: 497 Annotation: Subtype: Link Rect: 120, 246, 207, 234 ActionDest: 527 Annotation: Subtype: Link Rect: 228, 223, 290, 209 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 210, 66, 198 ActionDest: 592 Annotation: Subtype: Link Rect: 188, 174, 290, 162 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 162, 66, 150 ActionDest: 592 Annotation: Subtype: Link Rect: 170, 78, 237, 66 ActionDest: 592 Annotation: Subtype: Link Rect: 383, 738, 470, 726 ActionDest: 527 Annotation: Subtype: Link Rect: 518, 702, 545, 690 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 690, 341, 678 ActionDest: 592 Annotation: Subtype: Link Rect: 344, 690, 405, 678 ActionDest: 592 Annotation: Subtype: Link Rect: 350, 654, 405, 642 ActionDest: 592 Annotation: Subtype: Link Rect: 328, 630, 424, 618 ActionDest: 527 Annotation: Subtype: Link Rect: 430, 630, 505, 618 ActionDest: 592 Annotation: Subtype: Link Rect: 307, 582, 361, 570 ActionDest: 592 Annotation: Subtype: Link Rect: 307, 546, 361, 534 ActionDest: 497 Annotation: Subtype: Link Rect: 411, 510, 499, 498 ActionDest: 527 Annotation: Subtype: Link Rect: 417, 174, 501, 162 ActionDest: 592 Annotation: Subtype: Link Rect: 517, 174, 545, 162 ActionDest: 105 Annotation: Subtype: Link Rect: 304, 151, 332, 138 ActionDest: 134 Annotation: Subtype: Link Rect: 337, 151, 341, 138 ActionDest: 189 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 133, 450, 221, 438 ActionDest: 527 Annotation: Subtype: Link Rect: 163, 390, 250, 378 ActionDest: 527 Annotation: Subtype: Link Rect: 255, 390, 285, 378 ActionDest: 105 Annotation: Subtype: Link Rect: 165, 306, 259, 294 ActionDest: 592 Annotation: Subtype: Link Rect: 103, 234, 175, 222 ActionDest: 527 Annotation: Subtype: Link Rect: 179, 150, 270, 138 ActionDest: 592 Annotation: Subtype: Link Rect: 83, 78, 162, 66 ActionDest: 592 Annotation: Subtype: Link Rect: 168, 78, 227, 66 ActionDest: 527 Annotation: Subtype: Link Rect: 360, 438, 449, 426 ActionDest: 592 Annotation: Subtype: Link Rect: 453, 438, 483, 426 ActionDest: 105 Annotation: Subtype: Link Rect: 449, 366, 539, 354 ActionDest: 527 Annotation: Subtype: Link Rect: 513, 198, 545, 186 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 186, 346, 174 ActionDest: 527 Annotation: Subtype: Link Rect: 352, 186, 383, 174 ActionDest: 105 Annotation: Subtype: Link Rect: 436, 126, 492, 114 ActionDest: 592 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 103, 756, 112, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 123, 742, 133, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 138, 755, 148, 695 ActionDest: 497 Annotation: Subtype: Link Rect: 165, 749, 175, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 198, 742, 207, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 225, 747, 234, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 251, 755, 261, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 278, 752, 288, 695 ActionDest: 497 Annotation: Subtype: Link Rect: 305, 749, 314, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 344, 751, 353, 695 ActionDest: 497 Annotation: Subtype: Link Rect: 392, 741, 401, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 404, 741, 413, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 437, 755, 446, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 469, 747, 479, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 484, 747, 494, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 517, 740, 527, 695 ActionDest: 527 Rotate: 90 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 114, 741, 124, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 171, 738, 181, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 210, 741, 219, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 225, 741, 234, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 237, 713, 246, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 267, 753, 277, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 279, 744, 289, 707 ActionDest: 527 Annotation: Subtype: Link Rect: 291, 752, 301, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 312, 749, 321, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 333, 743, 342, 695 ActionDest: 497 Annotation: Subtype: Link Rect: 345, 713, 354, 695 ActionDest: 497 Annotation: Subtype: Link Rect: 359, 744, 369, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 380, 752, 390, 695 ActionDest: 592 Annotation: Subtype: Link Rect: 419, 754, 428, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 467, 744, 477, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 482, 756, 492, 695 ActionDest: 592 Rotate: 90 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 380, 765, 403, 757 ActionDest: 134 Annotation: Subtype: Link Rect: 54, 710, 116, 701 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 689, 102, 680 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 669, 115, 659 ActionDest: 497 Annotation: Subtype: Link Rect: 54, 630, 109, 620 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 585, 101, 576 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 540, 106, 531 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 502, 115, 492 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 469, 111, 459 ActionDest: 497 Annotation: Subtype: Link Rect: 54, 436, 109, 427 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 409, 111, 400 ActionDest: 497 Annotation: Subtype: Link Rect: 54, 373, 100, 364 ActionDest: 527 Annotation: Subtype: Link Rect: 114, 373, 128, 364 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 361, 87, 352 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 334, 114, 325 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 302, 107, 292 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 263, 107, 253 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 224, 100, 215 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 182, 101, 172 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 155, 98, 146 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 128, 101, 119 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 102, 119, 92 ActionDest: 592 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 52, 438, 131, 426 ActionDest: 527 Annotation: Subtype: Link Rect: 135, 438, 207, 426 ActionDest: 527 Annotation: Subtype: Link Rect: 199, 354, 285, 342 ActionDest: 527 Annotation: Subtype: Link Rect: 154, 330, 227, 318 ActionDest: 592 Annotation: Subtype: Link Rect: 232, 330, 290, 318 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 318, 66, 306 ActionDest: 592 Annotation: Subtype: Link Rect: 143, 270, 212, 258 ActionDest: 592 Annotation: Subtype: Link Rect: 242, 222, 290, 210 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 210, 112, 198 ActionDest: 527 Annotation: Subtype: Link Rect: 458, 450, 529, 438 ActionDest: 592 Annotation: Subtype: Link Rect: 533, 450, 545, 438 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 438, 398, 426 ActionDest: 527 Annotation: Subtype: Link Rect: 415, 366, 469, 354 ActionDest: 497 Annotation: Subtype: Link Rect: 502, 330, 545, 318 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 318, 360, 306 ActionDest: 592 Annotation: Subtype: Link Rect: 492, 258, 545, 246 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 246, 321, 234 ActionDest: 527 Annotation: Subtype: Link Rect: 325, 246, 377, 234 ActionDest: 592 Annotation: Subtype: Link Rect: 534, 198, 545, 186 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 186, 345, 174 ActionDest: 592 Annotation: Subtype: Link Rect: 343, 78, 434, 66 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 716, 113, 707 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 704, 131, 695 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 692, 72, 683 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 671, 108, 662 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 645, 121, 635 ActionDest: 497 Annotation: Subtype: Link Rect: 54, 618, 103, 608 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 597, 111, 588 ActionDest: 592 Annotation: Subtype: Link Rect: 54, 576, 113, 567 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 534, 104, 525 ActionDest: 527 Annotation: Subtype: Link Rect: 54, 507, 116, 498 ActionDest: 592 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 153, 690, 217, 678 ActionDest: 592 Annotation: Subtype: Link Rect: 213, 678, 288, 666 ActionDest: 497 Annotation: Subtype: Link Rect: 49, 666, 124, 654 ActionDest: 527 Annotation: Subtype: Link Rect: 133, 666, 220, 654 ActionDest: 497 Annotation: Subtype: Link Rect: 52, 642, 106, 630 ActionDest: 592 Annotation: Subtype: Link Rect: 122, 594, 213, 582 ActionDest: 592 Annotation: Subtype: Link Rect: 123, 510, 151, 498 ActionDest: 134 Annotation: Subtype: Link Rect: 157, 510, 235, 498 ActionDest: 527 Annotation: Subtype: Link Rect: 240, 510, 290, 498 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 498, 124, 486 ActionDest: 527 Annotation: Subtype: Link Rect: 131, 498, 199, 486 ActionDest: 592 Annotation: Subtype: Link Rect: 206, 498, 285, 486 ActionDest: 592 Annotation: Subtype: Link Rect: 132, 439, 198, 425 ActionDest: 527 Annotation: Subtype: Link Rect: 203, 439, 285, 425 ActionDest: 592 Annotation: Subtype: Link Rect: 190, 415, 256, 401 ActionDest: 527 Annotation: Subtype: Link Rect: 202, 379, 274, 365 ActionDest: 497 Annotation: Subtype: Link Rect: 206, 331, 274, 317 ActionDest: 592 Annotation: Subtype: Link Rect: 155, 307, 225, 293 ActionDest: 592 Annotation: Subtype: Link Rect: 122, 258, 182, 246 ActionDest: 527 Annotation: Subtype: Link Rect: 274, 198, 290, 186 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 186, 88, 174 ActionDest: 527 Annotation: Subtype: Link Rect: 92, 186, 166, 174 ActionDest: 527 Annotation: Subtype: Link Rect: 170, 186, 227, 174 ActionDest: 527 Annotation: Subtype: Link Rect: 203, 126, 229, 114 ActionDest: 134 Annotation: Subtype: Link Rect: 156, 102, 182, 90 ActionDest: 134 Annotation: Subtype: Link Rect: 398, 606, 464, 594 ActionDest: 527 Annotation: Subtype: Link Rect: 307, 498, 392, 486 ActionDest: 592 Annotation: Subtype: Link Rect: 395, 498, 423, 486 ActionDest: 105 Annotation: Subtype: Link Rect: 512, 474, 545, 462 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 462, 345, 450 ActionDest: 592 Annotation: Subtype: Link Rect: 383, 414, 457, 402 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 390, 375, 378 ActionDest: 592 Annotation: Subtype: Link Rect: 465, 175, 494, 162 ActionDest: 134 Annotation: Subtype: Link Rect: 498, 175, 502, 162 ActionDest: 189 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 212, 666, 288, 654 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 654, 136, 642 ActionDest: 592 Annotation: Subtype: Link Rect: 117, 558, 204, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 179, 546, 240, 534 ActionDest: 592 Annotation: Subtype: Link Rect: 244, 546, 290, 534 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 534, 66, 522 ActionDest: 592 Annotation: Subtype: Link Rect: 153, 426, 218, 414 ActionDest: 527 Annotation: Subtype: Link Rect: 222, 342, 290, 330 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 330, 67, 318 ActionDest: 592 Annotation: Subtype: Link Rect: 205, 294, 238, 282 ActionDest: 527 Annotation: Subtype: Link Rect: 80, 258, 141, 246 ActionDest: 527 Annotation: Subtype: Link Rect: 146, 258, 212, 246 ActionDest: 592 Annotation: Subtype: Link Rect: 190, 222, 225, 210 ActionDest: 527 Annotation: Subtype: Link Rect: 179, 174, 253, 162 ActionDest: 527 Annotation: Subtype: Link Rect: 258, 174, 290, 162 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 162, 92, 150 ActionDest: 592 Annotation: Subtype: Link Rect: 307, 630, 375, 618 ActionDest: 592 Annotation: Subtype: Link Rect: 455, 594, 503, 582 ActionDest: 592 Annotation: Subtype: Link Rect: 507, 594, 545, 582 ActionDest: 497 Annotation: Subtype: Link Rect: 304, 582, 321, 570 ActionDest: 497 Annotation: Subtype: Link Rect: 426, 546, 540, 534 ActionDest: 592 Annotation: Subtype: Link Rect: 420, 498, 515, 486 ActionDest: 592 Annotation: Subtype: Link Rect: 509, 402, 545, 390 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 390, 356, 378 ActionDest: 592 Annotation: Subtype: Link Rect: 474, 354, 545, 342 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 342, 321, 330 ActionDest: 592 Annotation: Subtype: Link Rect: 368, 258, 426, 246 ActionDest: 497 Annotation: Subtype: Link Rect: 484, 198, 540, 186 ActionDest: 497 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 224, 750, 290, 738 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 738, 66, 726 ActionDest: 527 Annotation: Subtype: Link Rect: 258, 726, 290, 714 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 714, 86, 702 ActionDest: 592 Annotation: Subtype: Link Rect: 90, 714, 158, 702 ActionDest: 527 Annotation: Subtype: Link Rect: 162, 714, 245, 702 ActionDest: 527 Annotation: Subtype: Link Rect: 249, 714, 290, 702 ActionDest: 497 Annotation: Subtype: Link Rect: 49, 702, 66, 690 ActionDest: 497 Annotation: Subtype: Link Rect: 163, 642, 246, 630 ActionDest: 527 Annotation: Subtype: Link Rect: 250, 642, 290, 630 ActionDest: 497 Annotation: Subtype: Link Rect: 49, 630, 66, 618 ActionDest: 497 Annotation: Subtype: Link Rect: 145, 510, 199, 498 ActionDest: 592 Annotation: Subtype: Link Rect: 203, 510, 220, 498 ActionDest: 592 Annotation: Subtype: Link Rect: 224, 510, 285, 498 ActionDest: 592 Annotation: Subtype: Link Rect: 178, 366, 251, 354 ActionDest: 592 Annotation: Subtype: Link Rect: 52, 330, 142, 318 ActionDest: 592 Annotation: Subtype: Link Rect: 163, 294, 249, 282 ActionDest: 592 Annotation: Subtype: Link Rect: 252, 294, 290, 282 ActionDest: 497 Annotation: Subtype: Link Rect: 304, 762, 321, 750 ActionDest: 497 Annotation: Subtype: Link Rect: 526, 714, 545, 702 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 702, 379, 690 ActionDest: 527 Annotation: Subtype: Link Rect: 383, 702, 454, 690 ActionDest: 527 Annotation: Subtype: Link Rect: 458, 702, 508, 690 ActionDest: 592 Annotation: Subtype: Link Rect: 512, 702, 545, 690 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 690, 344, 678 ActionDest: 527 Annotation: Subtype: Link Rect: 348, 690, 448, 678 ActionDest: 527 Annotation: Subtype: Link Rect: 453, 690, 513, 678 ActionDest: 497 Annotation: Subtype: Link Rect: 337, 666, 405, 654 ActionDest: 592 Annotation: Subtype: Link Rect: 338, 570, 409, 558 ActionDest: 527 Annotation: Subtype: Link Rect: 412, 570, 516, 558 ActionDest: 527 Annotation: Subtype: Link Rect: 520, 570, 545, 558 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 558, 342, 546 ActionDest: 527 Annotation: Subtype: Link Rect: 475, 534, 543, 522 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 522, 373, 510 ActionDest: 527 Annotation: Subtype: Link Rect: 377, 522, 465, 510 ActionDest: 592 Annotation: Subtype: Link Rect: 409, 474, 476, 462 ActionDest: 497 Annotation: Subtype: Link Rect: 480, 474, 545, 462 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 462, 321, 450 ActionDest: 527 Annotation: Subtype: Link Rect: 325, 462, 387, 450 ActionDest: 527 Annotation: Subtype: Link Rect: 393, 438, 452, 426 ActionDest: 527 Annotation: Subtype: Link Rect: 456, 438, 525, 426 ActionDest: 527 Annotation: Subtype: Link Rect: 386, 426, 452, 414 ActionDest: 592 Annotation: Subtype: Link Rect: 456, 426, 540, 414 ActionDest: 527 Annotation: Subtype: Link Rect: 432, 390, 532, 378 ActionDest: 527 Annotation: Subtype: Link Rect: 484, 366, 509, 354 ActionDest: 344 Annotation: Subtype: Link Rect: 463, 229, 511, 219 ActionDest: 497 Annotation: Subtype: Link Rect: 463, 214, 511, 204 ActionDest: 497 Annotation: Subtype: Link Rect: 463, 199, 534, 190 ActionDest: 592 Annotation: Subtype: Link Rect: 463, 184, 523, 175 ActionDest: 527 Annotation: Subtype: Link Rect: 463, 170, 511, 160 ActionDest: 497 Annotation: Subtype: Link Rect: 463, 155, 534, 145 ActionDest: 592 Annotation: Subtype: Link Rect: 463, 140, 534, 131 ActionDest: 592 Annotation: Subtype: Link Rect: 463, 125, 534, 116 ActionDest: 592 Annotation: Subtype: Link Rect: 463, 111, 511, 101 ActionDest: 497 Annotation: Subtype: Link Rect: 463, 96, 511, 87 ActionDest: 497 Annotation: Subtype: Link Rect: 463, 81, 534, 72 ActionDest: 592 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 96, 726, 166, 714 ActionDest: 497 Annotation: Subtype: Link Rect: 52, 678, 116, 666 ActionDest: 527 Annotation: Subtype: Link Rect: 158, 678, 233, 666 ActionDest: 592 Annotation: Subtype: Link Rect: 253, 558, 290, 546 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 546, 66, 534 ActionDest: 592 Annotation: Subtype: Link Rect: 182, 318, 249, 306 ActionDest: 527 Annotation: Subtype: Link Rect: 254, 318, 290, 306 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 306, 66, 294 ActionDest: 527 Annotation: Subtype: Link Rect: 195, 234, 248, 222 ActionDest: 592 Annotation: Subtype: Link Rect: 251, 234, 268, 222 ActionDest: 592 Annotation: Subtype: Link Rect: 272, 234, 290, 222 ActionDest: 592 Annotation: Subtype: Link Rect: 49, 222, 86, 210 ActionDest: 592 Annotation: Subtype: Link Rect: 58, 174, 152, 162 ActionDest: 527 Annotation: Subtype: Link Rect: 108, 150, 173, 138 ActionDest: 527 Annotation: Subtype: Link Rect: 178, 150, 268, 138 ActionDest: 527 Annotation: Subtype: Link Rect: 447, 630, 540, 618 ActionDest: 592 Annotation: Subtype: Link Rect: 520, 510, 545, 498 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 498, 341, 486 ActionDest: 527 Annotation: Subtype: Link Rect: 345, 498, 412, 486 ActionDest: 497 Annotation: Subtype: Link Rect: 324, 426, 398, 414 ActionDest: 527 Annotation: Subtype: Link Rect: 338, 342, 444, 330 ActionDest: 592 Annotation: Subtype: Link Rect: 390, 294, 483, 282 ActionDest: 527 Annotation: Subtype: Link Rect: 488, 294, 545, 282 ActionDest: 497 Annotation: Subtype: Link Rect: 304, 282, 322, 270 ActionDest: 497 Annotation: Subtype: Link Rect: 526, 258, 545, 246 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 246, 377, 234 ActionDest: 527 Annotation: Subtype: Link Rect: 365, 210, 458, 198 ActionDest: 592 Annotation: Subtype: Link Rect: 462, 210, 530, 198 ActionDest: 527 Annotation: Subtype: Link Rect: 383, 162, 446, 150 ActionDest: 592 Annotation: Subtype: Link Rect: 451, 162, 543, 150 ActionDest: 527 Annotation: Subtype: Link Rect: 304, 150, 370, 138 ActionDest: 497 Annotation: Subtype: Link Rect: 468, 126, 540, 114 ActionDest: 527 Annotation: Subtype: Link Rect: 337, 102, 389, 90 ActionDest: 592 Thumb: true Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 216, 762, 288, 750 ActionDest: 527 Annotation: Subtype: Link Rect: 49, 750, 128, 738 ActionDest: 497 Annotation: Subtype: Link Rect: 106, 546, 137, 534 ActionDest: 462 Annotation: Subtype: Link Rect: 89, 522, 120, 510 ActionDest: 462 Annotation: Subtype: Link Rect: 52, 450, 105, 438 ActionDest: 497 Annotation: Subtype: Link Rect: 475, 546, 501, 534 ActionDest: 480 Thumb: true Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 223, 150, 288, 138 ActionDest: 497 Annotation: Subtype: Link Rect: 49, 138, 137, 126 ActionDest: 592 Annotation: Subtype: Link Rect: 140, 78, 235, 66 ActionDest: 592 Annotation: Subtype: Link Rect: 239, 78, 290, 66 ActionDest: 592 Annotation: Subtype: Link Rect: 304, 186, 321, 174 ActionDest: 592 Annotation: Subtype: Link Rect: 367, 138, 393, 126 ActionDest: 134 Annotation: Subtype: Link Rect: 463, 114, 540, 102 ActionDest: 592 Thumb: true Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 130, 738, 213, 726 ActionDest: 527 Annotation: Subtype: Link Rect: 217, 618, 247, 606 ActionDest: 462 Annotation: Subtype: Link Rect: 131, 558, 204, 546 ActionDest: 527 Annotation: Subtype: Link Rect: 207, 558, 280, 546 ActionDest: 497 Annotation: Subtype: Link Rect: 191, 450, 277, 438 ActionDest: 527 Annotation: Subtype: Link Rect: 141, 246, 232, 237 Annotation: Subtype: Link Rect: 242, 218, 290, 209 Annotation: Subtype: Link Rect: 49, 210, 88, 201 Annotation: Subtype: Link Rect: 265, 182, 290, 173 Annotation: Subtype: Link Rect: 49, 174, 100, 165 Annotation: Subtype: Link Rect: 61, 146, 143, 137 Annotation: Subtype: Link Rect: 138, 117, 218, 108 Annotation: Subtype: Link Rect: 49, 80, 162, 71 Annotation: Subtype: Link Rect: 499, 246, 545, 237 Annotation: Subtype: Link Rect: 304, 238, 343, 229 Annotation: Subtype: Link Rect: 395, 210, 501, 201 Annotation: Subtype: Link Rect: 353, 174, 408, 165 Annotation: Subtype: Link Rect: 391, 138, 477, 129 Annotation: Subtype: Link Rect: 366, 109, 416, 100 Annotation: Subtype: Link Rect: 448, 80, 539, 71 Thumb: true Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 99, 749, 184, 740 Annotation: Subtype: Link Rect: 88, 721, 142, 712 Annotation: Subtype: Link Rect: 86, 685, 204, 676 Annotation: Subtype: Link Rect: 90, 657, 167, 648 Annotation: Subtype: Link Rect: 160, 637, 235, 628 Annotation: Subtype: Link Rect: 177, 609, 234, 600 Annotation: Subtype: Link Rect: 265, 581, 290, 572 Annotation: Subtype: Link Rect: 49, 573, 83, 564 Annotation: Subtype: Link Rect: 163, 545, 204, 536 Annotation: Subtype: Link Rect: 95, 517, 188, 508 Annotation: Subtype: Link Rect: 49, 481, 159, 472 Annotation: Subtype: Link Rect: 82, 445, 167, 436 Annotation: Subtype: Link Rect: 242, 417, 290, 408 Annotation: Subtype: Link Rect: 49, 409, 87, 400 Annotation: Subtype: Link Rect: 99, 381, 184, 372 Annotation: Subtype: Link Rect: 244, 361, 290, 352 Annotation: Subtype: Link Rect: 49, 353, 104, 344 Annotation: Subtype: Link Rect: 49, 325, 140, 316 Annotation: Subtype: Link Rect: 49, 289, 134, 280 Annotation: Subtype: Link Rect: 49, 253, 112, 244 Annotation: Subtype: Link Rect: 82, 233, 205, 224 Annotation: Subtype: Link Rect: 49, 197, 146, 188 Annotation: Subtype: Link Rect: 225, 170, 278, 161 Annotation: Subtype: Link Rect: 214, 150, 290, 141 Annotation: Subtype: Link Rect: 61, 115, 116, 106 Annotation: Subtype: Link Rect: 49, 88, 104, 79 Annotation: Subtype: Link Rect: 357, 757, 427, 748 Annotation: Subtype: Link Rect: 521, 737, 545, 728 Annotation: Subtype: Link Rect: 304, 729, 344, 720 Annotation: Subtype: Link Rect: 521, 701, 545, 692 Annotation: Subtype: Link Rect: 304, 693, 346, 684 Annotation: Subtype: Link Rect: 453, 657, 545, 648 Annotation: Subtype: Link Rect: 304, 649, 459, 640 Annotation: Subtype: Link Rect: 520, 629, 545, 620 Annotation: Subtype: Link Rect: 304, 621, 341, 612 Annotation: Subtype: Link Rect: 316, 593, 404, 584 Annotation: Subtype: Link Rect: 521, 565, 545, 556 Annotation: Subtype: Link Rect: 304, 557, 358, 548 Annotation: Subtype: Link Rect: 447, 529, 523, 520 Annotation: Subtype: Link Rect: 382, 509, 437, 500 Annotation: Subtype: Link Rect: 370, 481, 449, 472 Annotation: Subtype: Link Rect: 423, 453, 498, 444 Annotation: Subtype: Link Rect: 304, 425, 375, 416 Annotation: Subtype: Link Rect: 304, 397, 364, 388 Annotation: Subtype: Link Rect: 469, 377, 541, 368 Annotation: Subtype: Link Rect: 304, 349, 382, 340 Annotation: Subtype: Link Rect: 304, 321, 392, 312 Annotation: Subtype: Link Rect: 378, 293, 442, 284 Annotation: Subtype: Link Rect: 340, 257, 501, 248 Annotation: Subtype: Link Rect: 304, 221, 378, 212 Annotation: Subtype: Link Rect: 304, 185, 387, 176 Annotation: Subtype: Link Rect: 358, 150, 422, 141 Annotation: Subtype: Link Rect: 382, 131, 460, 122 Annotation: Subtype: Link Rect: 424, 96, 509, 87 Annotation: Subtype: Link Rect: 440, 68, 537, 59 Thumb: true Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 453, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 130, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 159, 749, 235, 740 Annotation: Subtype: Link Rect: 146, 721, 237, 712 Annotation: Subtype: Link Rect: 131, 685, 209, 675 Annotation: Subtype: Link Rect: 193, 665, 268, 655 Annotation: Subtype: Link Rect: 146, 637, 209, 627 Annotation: Subtype: Link Rect: 108, 600, 177, 591 Annotation: Subtype: Link Rect: 171, 572, 225, 563 Annotation: Subtype: Link Rect: 61, 544, 148, 534 Annotation: Subtype: Link Rect: 225, 516, 280, 506 Annotation: Subtype: Link Rect: 206, 495, 290, 486 Annotation: Subtype: Link Rect: 49, 487, 62, 478 Annotation: Subtype: Link Rect: 88, 459, 152, 450 Annotation: Subtype: Link Rect: 150, 431, 204, 421 Annotation: Subtype: Link Rect: 190, 403, 256, 393 Annotation: Subtype: Link Rect: 49, 374, 124, 365 Annotation: Subtype: Link Rect: 265, 346, 290, 337 Annotation: Subtype: Link Rect: 49, 338, 106, 329 Annotation: Subtype: Link Rect: 265, 310, 290, 300 Annotation: Subtype: Link Rect: 49, 302, 122, 292 Annotation: Subtype: Link Rect: 265, 282, 290, 272 Annotation: Subtype: Link Rect: 49, 274, 119, 264 Annotation: Subtype: Link Rect: 146, 246, 227, 236 Annotation: Subtype: Link Rect: 177, 189, 262, 180 Annotation: Subtype: Link Rect: 192, 161, 290, 151 Annotation: Subtype: Link Rect: 155, 141, 205, 131 Annotation: Subtype: Link Rect: 49, 104, 128, 95 Annotation: Subtype: Link Rect: 410, 749, 513, 740 Annotation: Subtype: Link Rect: 436, 728, 485, 719 Annotation: Subtype: Link Rect: 388, 691, 450, 682 Annotation: Subtype: Link Rect: 398, 655, 470, 646 Annotation: Subtype: Link Rect: 408, 626, 467, 617 Annotation: Subtype: Link Rect: 410, 597, 500, 588 Annotation: Subtype: Link Rect: 496, 576, 545, 567 Annotation: Subtype: Link Rect: 343, 548, 435, 539 Annotation: Subtype: Link Rect: 431, 519, 512, 510 Annotation: Subtype: Link Rect: 353, 490, 430, 481 Annotation: Subtype: Link Rect: 316, 461, 398, 452 Annotation: Subtype: Link Rect: 521, 440, 545, 431 Annotation: Subtype: Link Rect: 304, 432, 377, 423 Annotation: Subtype: Link Rect: 331, 403, 409, 394 Annotation: Subtype: Link Rect: 425, 374, 545, 365 Annotation: Subtype: Link Rect: 304, 366, 387, 357 Annotation: Subtype: Link Rect: 447, 337, 518, 328 Annotation: Subtype: Link Rect: 304, 308, 384, 299 Annotation: Subtype: Link Rect: 468, 279, 520, 270 Annotation: Subtype: Link Rect: 348, 250, 407, 241 Annotation: Subtype: Link Rect: 493, 221, 545, 212 Annotation: Subtype: Link Rect: 437, 192, 512, 183 Annotation: Subtype: Link Rect: 428, 163, 512, 154 Annotation: Subtype: Link Rect: 368, 134, 441, 125 Annotation: Subtype: Link Rect: 341, 104, 420, 95 Thumb: true Checksum: 737cb506 Type: CRC32 Checksum: 64cb31481e8ab9dcea49df695cf9eab0 Type: MD5 Checksum: d2dd812d26b2c8fa42e0904304d7ea22084cae1c Type: SHA-1 Checksum: b6b199012973083503ff524c1ae9b0298da213992aa5c410d5bae16bba41874f Type: SHA-256