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Title:           Immortalized human myotonic dystrophy type 1 muscle cell lines to address patient heterogeneity
Subject:         ISCIENCE, 27 (2024) 109930. doi:10.1016/j.isci.2024.109930
Author:          Judit Núñez-Manchón
Creator:         Elsevier
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      Title: Immortalized human myotonic dystrophy type 1 muscle cell lines to address patient heterogeneity
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Immortalization of muscle cells derived from patients with myotonic dystrophy type 1 with clinical heterogeneity
          Destination: slink1
         Item: 
          Title: A high level of CTG repeats instability characterized all studied myotonic dystrophy type 1 cell lines
          Destination: slink2
         Item: 
          Title: CTCF1 methylation level is increased in the myotonic dystrophy type 1 immortalized cell lines when compared with immortaliz ...
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         Item: 
          Title: Myotonic dystrophy type 1 myoblasts show higher cell proliferation and reduction of early myogenic markers
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         Item: 
          Title: Myotonic dystrophy type 1 immortalized cells maintain a reduced fusion index as observed in their parental lines
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         Item: 
          Title: Myotonic dystrophy type 1 immortalized myotubes maintain patient-derived heterogeneity and have equal or greater RNA foci a ...
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         Item: 
          Title: Myotonic dystrophy type 1 immortalized myotubes showed the same pathological splicing alterations than their primary myotubes
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         Item: 
          Title: Antisense oligonucleotide treatment is equally efficient in myotonic dystrophy type 1 immortalized cell lines as in their o ...
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        Title: Discussion
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         Item: 
          Title: Limitations of the study
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       Item: 
        Title: Supplemental information
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        Title: Acknowledgments
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        Title: Author contributions
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        Title: Declaration of interests
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        Title: Supporting Citations
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       Item: 
        Title: References
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       Item: 
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            Title: Data and code availability
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          Title: Experimental model and study participant details
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            Title: Sample collection and patient characterization
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            Title: Cell culture and immortalization
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          Title: Method details
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            Title: CTG expansion sizing
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            Title: DNA methylation analysis
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            Title: Expression analysis by qPCR
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            Title: Impedance measurements
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            Title: Jess Western blot
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            Title: Fluorescence in situ hybridization (FISH) and immunocytochemistry (ICC)
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            Title: Splicing analysis
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            Title: Treatment
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         Item: 
          Title: Quantification and statistical analysis
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           Item: 
            Title: Statistical analysis
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    Author: Judit Núñez-Manchón
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