9232b2b1a73ee46e842c12ac982e10ea fnagi-16-1386944.pdf 2b0b745d213fa7a09bc50699190c01815ac5b16e fnagi-16-1386944.pdf e616607de39c00948f2f1fd85867e0f1a686d36afe02472dc95c7a694b25b044 fnagi-16-1386944.pdf Title: Lamivudine modulates the expression of neurological impairment-related genes and LINE-1 retrotransposons in brain tissues of a Down syndrome mouse model Subject: Elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and neurodevelopmental diseases, including Down syndrome (DS), which is the most common chromosomal condition causing intellectual disability globally. Author: Alessandra Borgognone; Maria Casadellà; María Martínez de Lagrán; Roger Paredes; Bonaventura Clotet; Mara Dierssen; Aleix Elizalde-Torrent Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Tue Jul 16 14:34:51 2024 CEST ModDate: Tue Jul 16 14:35:16 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 6362676 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DMFAIX+MuseoSans-500 Type 1C Custom yes yes yes 1286 0 PZFPUZ+MuseoSans-300 Type 1C Custom yes yes yes 1294 0 EGQBWV+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 1299 0 EGQBWV+MuseoSans-700 Type 1C Custom yes yes yes 1300 0 BITPGB+GentiumPlus CID TrueType Identity-H yes yes yes 157 0 EGQBWV+MinionPro-Regular Type 1C Custom yes yes yes 146 0 FGTSKT+STIXGeneral-Regular Type 1C Custom yes yes yes 177 0 USJEMP+MinionPro-It Type 1C Custom yes yes yes 149 0 MWEYEF+STIX-Regular Type 1C WinAnsi yes yes yes 184 0 GNCOYR+STIXGeneral-Italic Type 1C Custom yes yes yes 216 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-24 02:46:27 CEST RepresentationInformation: fnagi-16-1386944.pdf ReportingModule: BYTESTREAM, Rel. 1.4 (2018-10-01) LastModified: 2025-06-23 15:54:56 CEST Size: 6362676 Format: bytestream Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/octet-stream Checksum: 4ce6f57f Type: CRC32 Checksum: 9232b2b1a73ee46e842c12ac982e10ea Type: MD5 Checksum: 2b0b745d213fa7a09bc50699190c01815ac5b16e Type: SHA-1 Checksum: e616607de39c00948f2f1fd85867e0f1a686d36afe02472dc95c7a694b25b044 Type: SHA-256