d4f83ccab8a77ed8f51a6f94b1df01d0 jcm-13-03123.pdf 9d80e74c4e4d1137d04aa01a8ff463c9164fe3c8 jcm-13-03123.pdf 81d245914847d650bf4a7b8933666fb54e1c82bfee1721df48909fe7622d90d4 jcm-13-03123.pdf Title: Enhancing the First-Pass Effect in Acute Stroke: The Impact of Stent Retriever Characteristics Subject: Introduction: Although stentrievers (SRs) have been a mainstay of mechanical thrombectomy (MT), and current guidelines recommend the use of SRs in the treatment of large vessel occlusion stroke (LVO), there is a paucity of studies in the literature comparing SRs directly against each other in terms of mechanical and functional properties. Timely access to endovascular therapy and the ability to restore intracranial flow in a safe, efficient, and efficacious manner have been critical to the success of MT. This study aimed to investigate the impact of contemporary SR characteristics, including model, brand, size, and length, on the first-pass effect (FPE) in patients with acute ischemic stroke. Methods: Consecutive patients with M1 occlusion treated with a single SR+BGC were recruited from the ROSSETTI registry. The primary outcome was the FPE that was defined as modified (mFPE) or true (tFPE) for the achievement of modified thrombolysis in cerebral infarction (mTICI) grades 2b-3 or 3 after a single device pass, respectively. We compared patients who achieved mFPE with those who achieved tFPE according to SR characteristics. Results: We included 610 patients (52.3% female and 47.7% male, mean age 75.1 13.62 years). mFPE was achieved in 357 patients (58.5%), whereas tFPE was achieved in 264 (43.3%). There was no significant association between SR characteristics and mFPE or tFPE. Specifically, the SR size did not show a statistically significant relationship with improvement in FPE. Similarly, the length of the SR did not yield significant differences in the mFPE and tFPE, even when the data were grouped. Conclusions: Our data indicate that contemporary SR-mediated thrombectomy characteristics, including model, brand, size, and length, do not significantly affect the FPE. Keywords: thrombectomy; stroke; endovascular; stentriever Author: Eduardo Murias, Josep Puig, Carmen Serna-Candel, Eva María Gonzalez, Manuel Moreu, Elvira Jiménez-Gómez, Luis SanRoman, Fernando Aparici-Robles, Mikel Terceño, Antonio Mosqueira Martínez, Sonia Aixut, Veredas Romero, Jose Carlos Mendez, Antonio Sagredo-Barra, Yeray Aguilar, Mariano Espinosa de Rueda, Miguel Angel Castaño Blázquez, Saima Bashir, José Rodríguez Castro, Alfonso Lopez-Frías, Jose María Jiménez, Juan Chaviano, Victor Maestro, Javier Manso, Antonio Lopez-Rueda, Sebastià Remollo, Lluis Morales-Caba, Marc Comas-Cufí, Pedro Vega and on behalf of Rossetti Registry Investigators Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sun May 26 12:49:50 2024 CEST ModDate: Sun May 26 12:55:05 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 249630 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JUXSQN+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 TBLUZA+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 AZYRBP+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 COPMAQ+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 YWQWLZ+VnURWPalladioL Type 1 Custom yes yes yes 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 TOSMPJ+CMSY10 Type 1 Builtin yes yes yes 68 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 85 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-15 02:44:15 CEST RepresentationInformation: jcm-13-03123.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-14 15:16:53 CEST Size: 249630 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 214 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Enhancing the First-Pass Effect in Acute Stroke: The Impact of Stent Retriever Characteristics Author: Eduardo Murias, Josep Puig, Carmen Serna-Candel, Eva María Gonzalez, Manuel Moreu, Elvira Jiménez-Gómez, Luis SanRoman, Fernando Aparici-Robles, Mikel Terceño, Antonio Mosqueira Martínez, Sonia Aixut, Veredas Romero, Jose Carlos Mendez, Antonio Sagredo-Barra, Yeray Aguilar, Mariano Espinosa de Rueda, Miguel Angel Castaño Blázquez, Saima Bashir, José Rodríguez Castro, Alfonso Lopez-Frías, Jose María Jiménez, Juan Chaviano, Victor Maestro, Javier Manso, Antonio Lopez-Rueda, Sebastià Remollo, Lluis Morales-Caba, Marc Comas-Cufí, Pedro Vega and on behalf of Rossetti Registry Investigators Subject: Introduction: Although stentrievers (SRs) have been a mainstay of mechanical thrombectomy (MT), and current guidelines recommend the use of SRs in the treatment of large vessel occlusion stroke (LVO), there is a paucity of studies in the literature comparing SRs directly against each other in terms of mechanical and functional properties. Timely access to endovascular therapy and the ability to restore intracranial flow in a safe, efficient, and efficacious manner have been critical to the success of MT. This study aimed to investigate the impact of contemporary SR characteristics, including model, brand, size, and length, on the first-pass effect (FPE) in patients with acute ischemic stroke. Methods: Consecutive patients with M1 occlusion treated with a single SR+BGC were recruited from the ROSSETTI registry. The primary outcome was the FPE that was defined as modified (mFPE) or true (tFPE) for the achievement of modified thrombolysis in cerebral infarction (mTICI) grades 2b-3 or 3 after a single device pass, respectively. We compared patients who achieved mFPE with those who achieved tFPE according to SR characteristics. Results: We included 610 patients (52.3% female and 47.7% male, mean age 75.1 13.62 years). mFPE was achieved in 357 patients (58.5%), whereas tFPE was achieved in 264 (43.3%). There was no significant association between SR characteristics and mFPE or tFPE. Specifically, the SR size did not show a statistically significant relationship with improvement in FPE. Similarly, the length of the SR did not yield significant differences in the mFPE and tFPE, even when the data were grouped. Conclusions: Our data indicate that contemporary SR-mediated thrombectomy characteristics, including model, brand, size, and length, do not significantly affect the FPE. 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