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Title:           Challenges encountered in the enantioselective analysis of new psychoactive substances exemplified by clephedrone (4-CMC)
Subject:         Journal of Pharmaceutical and Biomedical Analysis, 248 (2024) 116275. doi:10.1016/j.jpba.2024.116275
Keywords:        Chiral HPLC,Clephedrone and metabolites,Enantioseparation,Hydrolysis of glucuronides,Stability of clephedrone in various biological matrices,Complexity of analytical challenge
Author:          Saba Jorbenadze
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      Title: Challenges encountered in the enantioselective analysis of new psychoactive substances exemplified by clephedrone (4-CMC)
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        Title: 1 Introduction
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        Title: 2 Experimental part
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          Title: 2.1 Reagents and standards
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          Title: 2.2 Chiral columns
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          Title: 2.3 Identification of 4-CMC metabolites
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          Title: 2.4 High-performance liquid chromatography  tandem mass spectrometry (HPLC MS/MS) analysis
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          Title: 2.5 Human samples
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          Title: 2.6 Sample preparation
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            Title: 2.6.1 OF and urine
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          Title: 2.7 Stability study of 4-CMC is blood, oral fluid and urine
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        Title: 3 Results and discussion
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          Title: 3.1 Identification of phase-1 metabolites of 4-CMC
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          Title: 3.2 Development of an enantioselective HPLC-MS/MS method for the separation of 4-CMC and its phase-1 metabolites
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          Title: 3.3 Stability of CMC in human blood, OF and urine
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          Title: 3.5 Application of the method to urine samples
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        Title: CRediT authorship contribution statement
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        Title: Declaration of Competing Interest
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    Keywords: Chiral HPLC,Clephedrone and metabolites,Enantioseparation,Hydrolysis of glucuronides,Stability of clephedrone in various biological matrices,Complexity of analytical challenge
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  Checksum: 566b6120
   Type: CRC32
  Checksum: bc8631b07ce251786f644496612551f5
   Type: MD5
  Checksum: 9d0f6a7c696866eb8479c0f63d9a179e2453ffc1
   Type: SHA-1
  Checksum: b34dcfedbea935906fa045830697b655befbdc53a6405b78e598b0a43da6229a
   Type: SHA-256