eb6f5a122b9645897d5fdaa56bc1110c elife_90964_v1.pdf 742ff585372ee4a564e7134d31c3c8e06f451b3d elife_90964_v1.pdf 5bc59aae2f7d4d29dc88bd1b5c43aba992acb6122e148eee09e95f223158a066 elife_90964_v1.pdf Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Jul 19 11:09:02 2024 CEST ModDate: Fri Jul 19 11:09:05 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 5011842 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WVTTJV+AvenirLTStd-Medium Type 1C Custom yes yes yes 2547 0 VRJNVX+AvenirLTStd-MediumOblique Type 1C Custom yes yes yes 2548 0 VRJNVX+AvenirLTStd-Black Type 1C Custom yes yes yes 2549 0 TOKBTB+AvenirLTStd-Roman Type 1C Custom yes yes yes 2550 0 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ESRFRF+STIXGeneral-Regular-Identity-H CID Type 0C Identity-H yes yes yes 2400 0 ESRFRF+STIXGeneral-Italic-Identity-H CID Type 0C Identity-H yes yes yes 2398 0 ESRFRF+STIXGeneral-Italic-Identity-H CID Type 0C Identity-H yes yes yes 2391 0 DOCZDH+STIXGeneral-Regular-Identity-H CID Type 0C Identity-H yes yes yes 2396 0 DOCZDH+STIXGeneral-Italic-Identity-H CID Type 0C Identity-H yes yes yes 2403 0 KYUZXT+CMMI9 Type 1C Custom yes yes no 2395 0 LCJFLR+CMEX9 Type 1C Custom yes yes yes 2401 0 HUFXHZ+CMR9 Type 1C Custom yes yes no 2390 0 KYUZXT+CMSY9 Type 1C Custom yes yes yes 2402 0 KYUZXT+CMSY9 Type 1C Custom yes yes yes 2394 0 HUFXHZ+CMR9 Type 1C Custom yes yes no 2393 0 KYUZXT+CMMI9 Type 1C Custom yes yes no 2389 0 HUFXHZ+CMR9 Type 1C Custom yes yes no 2388 0 KYUZXT+CMMI9 Type 1C Custom yes yes no 2392 0 CPSTPJ+Avenir-Roman CID TrueType Identity-H yes yes yes 2407 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-01 02:08:50 CEST RepresentationInformation: elife_90964_v1.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-30 14:15:35 CEST Size: 5011842 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 2614 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex Children: Item: Title: eLife assessment Item: Title: Introduction Item: Title: Results Children: Item: Title: Progressive demyelination causes CV slowing and AP failures in model neurons Item: Title: Remyelination leads to partial recovery from CV slowing and AP failures Item: Title: AP failures impair performance in a neural network model of working memory Item: Title: Impact of demyelination and remyelination on working memory Children: Item: Title: Demyelination impairs working memory performance compared to control networks Item: Title: Complete remyelination recovers network function Item: Title: Incomplete remyelination leads to partial recovery Item: Title: Alternative working memory mechanisms Item: Title: Simulated heterogenous myelin alterations match empirical data Children: Item: Title: Fewer normal myelin sheaths lead to decreased network performance Item: Title: Shorter and thinner myelinated segments impair working memory Item: Title: Discussion Children: Item: Title: Myelin changes affect AP propagation in a cohort of model neurons Item: Title: Myelin changes impair working memory function Item: Title: Conclusions Item: Title: Methods Children: Item: Title: Single neuron model Item: Title: Building a cohort of control model neurons Item: Title: Simulating myelin alterations Item: Title: Statistical assessment of parameter importance Item: Title: Spiking neural network model Item: Title: Network simulations with spatially modulated correlations Item: Title: Simulating a cohort of young (control) networks Item: Title: Modeling the effects of demyelination and remyelination in the network model Children: Item: Title: Modeling AP propagation failures in the network Item: Title: Modeling conduction velocity slowing in the network Item: Title: Quantification of normal myelin sheaths in groups of model neurons containing both intact and demyelinated axons Item: Title: Quantification of new myelin sheaths in groups of model neurons containing both intact and remyelinated axons Item: Title: Measures of working memory performance Children: Item: Title: Memory strength Item: Title: Decoded cue location Item: Title: Memory duration Item: Title: Memory drift Item: Title: Memory diffusion Item: Title: Acknowledgements Item: Title: Additional information Children: Item: Title: Funding Item: Title: Author contributions Item: Title: Author ORCIDs Item: Title: Peer review material Item: Title: Additional files Children: Item: Title: Supplementary files Item: Title: References Info: Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Jul 19 11:09:02 CEST 2024 ModDate: Fri Jul 19 11:09:05 CEST 2024 ID: 0xeea1fe84712a384d84affd91a8fcfff6, 0xd4373a408d6ce749b925350204e800b6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 650 ImageHeight: 488 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 652 ImageHeight: 490 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: 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NVEMNN+STIXGeneral-Regular-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: PYDYPJ+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: OZTSBL+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: QCSEDH+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: GAUWTB+STIXGeneral-Regular-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: TEGWTB+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: UIQCHZ+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: WLUOJV+STIXGeneral-Regular-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: YOTALR+STIXGeneral-Italic-Identity-H Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: UASCHZ+CMMI8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: UASCHZ+CMMI8 Flags: Serif, Symbolic, Italic FontBBox: -24, -250, 1110, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SPVVFD+AvenirLTStd-BlackOblique FontSubset: true FirstChar: 30 LastChar: 246 FontDescriptor: FontName: SPVVFD+AvenirLTStd-BlackOblique Flags: Nonsymbolic, Italic FontBBox: -159, -275, 1160, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RLGPRF+AvenirLTStd-Heavy FontSubset: true FirstChar: 31 LastChar: 150 FontDescriptor: FontName: RLGPRF+AvenirLTStd-Heavy Flags: Nonsymbolic FontBBox: -166, -250, 1160, 939 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QHWJDH+Helvetica-Condensed-Bold FontSubset: true FirstChar: 134 LastChar: 135 FontDescriptor: FontName: QHWJDH+Helvetica-Condensed-Bold Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: UASCHZ+CMMI8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: UASCHZ+CMMI8 Flags: Serif, Symbolic, Italic FontBBox: -24, -250, 1110, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YWRVLR+CMEX7 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: YWRVLR+CMEX7 Flags: Serif, Symbolic FontBBox: -12, -2951, 1627, 770 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YWRVLR+CMSY7 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: YWRVLR+CMSY7 Flags: Serif, Symbolic, Italic FontBBox: -15, -951, 1251, 782 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WDROJV+CMSY8 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: WDROJV+CMSY8 Flags: Serif, Symbolic, Italic FontBBox: -30, -955, 1185, 779 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WDROJV+CMSY8 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: WDROJV+CMSY8 Flags: Serif, Symbolic, Italic FontBBox: -30, -955, 1185, 779 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UASCHZ+CMMI8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: UASCHZ+CMMI8 Flags: Serif, Symbolic, Italic FontBBox: -24, -250, 1110, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WDROJV+CMSY8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: WDROJV+CMSY8 Flags: Serif, Symbolic, Italic FontBBox: -30, -955, 1185, 779 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIHDPJ+AvenirLTStd-Light FontSubset: true FirstChar: 28 LastChar: 241 FontDescriptor: FontName: PIHDPJ+AvenirLTStd-Light Flags: Nonsymbolic FontBBox: -167, -250, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UASCHZ+CMMI8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: UASCHZ+CMMI8 Flags: Serif, Symbolic, Italic FontBBox: -24, -250, 1110, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UASCHZ+CMMI8 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: UASCHZ+CMMI8 Flags: Serif, Symbolic, Italic FontBBox: -24, -250, 1110, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OESXBL+AvenirLTStd-Oblique FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OESXBL+AvenirLTStd-Oblique Flags: Nonsymbolic, Italic FontBBox: -166, -277, 1057, 928 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NFIRNN+AvenirLTStd-BookOblique FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: NFIRNN+AvenirLTStd-BookOblique Flags: Nonsymbolic, Italic FontBBox: -167, -288, 1044, 920 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ROFFRF+AvenirLTStd-Book FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: ROFFRF+AvenirLTStd-Book Flags: Nonsymbolic FontBBox: -167, -288, 1000, 920 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MBTLZP+MSAM10 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: MBTLZP+MSAM10 Flags: Serif, Symbolic FontBBox: 8, -463, 1331, 1003 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MBTLZP+AvenirLTStd-LightOblique FontSubset: true FirstChar: 114 LastChar: 114 FontDescriptor: FontName: MBTLZP+AvenirLTStd-LightOblique Flags: Nonsymbolic, Italic FontBBox: -168, -277, 1039, 932 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: LADVLR+CMR7 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: LADVLR+CMR7 Flags: Serif, Symbolic FontBBox: -27, -250, 1122, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HUFXHZ+CMR9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: HUFXHZ+CMR9 Flags: Serif, Symbolic FontBBox: -39, -250, 1036, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LADVLR+CMMI7 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: LADVLR+CMMI7 Flags: Serif, Symbolic, Italic FontBBox: -1, -250, 1171, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YWRVLR+CMEX7 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: YWRVLR+CMEX7 Flags: Serif, Symbolic FontBBox: -12, -2951, 1627, 770 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 26 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HUFXHZ+CMR9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: HUFXHZ+CMR9 Flags: Serif, Symbolic FontBBox: -39, -250, 1036, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HUFXHZ+CMR9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: HUFXHZ+CMR9 Flags: Serif, Symbolic FontBBox: -39, -250, 1036, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HUFXHZ+CMR9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: HUFXHZ+CMR9 Flags: Serif, Symbolic FontBBox: -39, -250, 1036, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LCJFLR+CMEX9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: LCJFLR+CMEX9 Flags: Serif, Symbolic FontBBox: -25, -2958, 1495, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 29 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KYUZXT+CMSY9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMSY9 Flags: Serif, Symbolic, Italic FontBBox: -29, -958, 1146, 777 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KYUZXT+CMMI9 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KYUZXT+CMMI9 Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WVTTJV+AvenirLTStd-Medium FontSubset: true FirstChar: 31 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