1f3a5feb9dc54c2d6e39f841d947b67a  Pseudophosphorylation_single_residues_J_domain_DNAJA2_regulates.pdf
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bba5225a1be4291ce174e7bac85f59abed3a53e30608d2af54fe30eb92618225  Pseudophosphorylation_single_residues_J_domain_DNAJA2_regulates.pdf

Title:           Pseudophosphorylation of single residues of the J‐domain of DNAJA2 regulates the holding/folding balance of the Hsc70 system
Subject:         Protein Science 2024.33:e5105
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      Title: Pseudophosphorylation of single residues of the J-domain of DNAJA2 regulates the holding/folding balance of the Hsc70 system
      Destination: atl_PRO_5105_
      Children: 
       Item: 
        Title: 1  INTRODUCTION
        Destination: HeadingPRO_5105pro5105-sec-0001
       Item: 
        Title: 2  RESULTS
        Destination: HeadingPRO_5105pro5105-sec-0002
        Children: 
         Item: 
          Title: 2.1  Design and evaluation of DNAJA2 variants with phosphomimetic substitutions in the J-domain
          Destination: HeadingPRO_5105pro5105-sec-0003
         Item: 
          Title: 2.2  Pseudophosphorylation of Y10 and S51 regulates the activity of the Hsc70 system
          Destination: HeadingPRO_5105pro5105-sec-0004
          Children: 
           Item: 
            Title: 2.2.1  Pseudophosphorylation of Y10 impairs assistance of Hsc70 during client remodeling
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           Item: 
            Title: 2.2.2  Phosphorylation of S51 could function as a reversible switch that controls the interaction of DNAJA2 with Hsc70
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         Item: 
          Title: 2.3  Phosphorylated JDs recapitulate results from full-length phosphomimetic variants
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         Item: 
          Title: 2.4  Structural basis for the functional regulation of the Hsp70 system by J-domain phosphorylation
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          Children: 
           Item: 
            Title: 2.4.1  Molecular dynamics (MD)
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           Item: 
            Title: 2.4.2  Nuclear magnetic resonance (NMR)
            Destination: HeadingPRO_5105pro5105-sec-0010
       Item: 
        Title: 3  DISCUSSION
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       Item: 
        Title: 4  MATERIALS AND METHODS
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        Children: 
         Item: 
          Title: 4.1  Cloning, expression, and purification of proteins
          Destination: HeadingPRO_5105pro5105-sec-0013
         Item: 
          Title: 4.2  ATPase assay
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          Title: 4.3  Holding activity
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         Item: 
          Title: 4.4  Refolding of unfolded luciferase: folding activity
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         Item: 
          Title: 4.5  Disaggregase activity
          Destination: HeadingPRO_5105pro5105-sec-0017
         Item: 
          Title: 4.6  Chaperone binding to G6PDH aggregates
          Destination: HeadingPRO_5105pro5105-sec-0018
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          Title: 4.7  Circular dichroism (CD)
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          Title: 4.8  NMR
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         Item: 
          Title: 4.9  Homology modeling, MD simulations, and docking
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         Item: 
          Title: 4.10  Statistical analysis
          Destination: HeadingPRO_5105pro5105-sec-0022
       Item: 
        Title: AUTHOR CONTRIBUTIONS
        Destination: HeadingPRO_5105pro5105-sec-0026
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: HeadingPRO_5105pro5105-sec-0023
       Item: 
        Title: FUNDING INFORMATION
        Destination: HeadingPRO_5105pro5105-sec-0024
       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
        Destination: HeadingPRO_5105pro5105-sec-0025
       Item: 
        Title: REFERENCES
        Destination: HeadingPRO_5105pro5105-bibl-00011
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