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METHODS Children: Item: Title: I.1. Eligibility criteria: (Protocol v.7.0) Item: Title: I.2. Dose Limiting Toxicity (DLT) Item: Title: I.3. NGS panels Item: Title: I.4 Bone Marrow assessments Item: Title: I.5. Iadademstat PK determinations Item: Title: I.6 LSD1 target engagement Item: Title: I.7 Statistical Methods Item: Title: I.8. Response Definitions Item: Title: I.9 Drug Manufacture Item: Title: II. ACCRUAL PER SITE Item: Title: III. SUPPLEMENTAL TABLES Children: Item: Title: Table S1. Reasons for Treatment Discontinuation Item: Title: Table S2. Safety Summary Item: Title: Table S3. Iadademstat related AEs by patient’s sex Item: Title: Table S4. AEs leading to iadademstat discontinuation. Item: Title: Table S5. Cause of Death Item: Title: Table S6. Efficacy in Subgroups Item: Title: Table S7. PK Analysis Item: Title: Table S8. LSD1 Target Engagement Analysis Item: Title: IV. SUPPLEMENTAL FIGURES. Children: Item: Title: Figure S1. Event-Free-Survival and Overall Survival Analysis Item: Title: Figure S2. EAS mutational profile and associated responses Item: Title: Figure S3. Exposure and PD/Dose-response relationship and safety analysis per dose cohort Item: Title: V. REFERENCES Item: Title: Doc - Oct 25 2022 - 10-46 PM Item: Title: CL02-ORY-1001-AML_ALICE_Protocol_v7.0_17May2022_FE Item: Title: 2022 10 03CL02-ORY-1001-AML_ALICE_SAP PPT and ELN22__v1.0_15Oct2022 for signature Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 631 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 632 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 149 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 149 ImageHeight: 77 BitsPerSample: 8 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