50b50a694e4e654ef5a5bb0a6a28261e 313086.pdf 5aa906e1ea5e1b86f4ff93a94b8eb0525d6be220 313086.pdf 6a9ba954307f253c95ae0fa8549a7bee9e8cc87ea7684ee2b242f9ee591d8771 313086.pdf Title: Down Syndrome Biobank Consortium: A perspective Subject: Alzheimer's & Dementia 2024.20:2262-2272 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Tue Mar 12 11:50:08 2024 CET ModDate: Thu Jun 26 14:34:21 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 8477187 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AOPJPE+Lato-Regular Type 1C WinAnsi yes yes no 46 0 AOPKFD+Lato-Bold Type 1C WinAnsi yes yes no 47 0 AOPKNB+Lato-Italic Type 1C WinAnsi yes yes no 48 0 AOPLDP+STIXTwoText-Italic Type 1C Custom yes yes yes 49 0 Times-Roman Type 1 WinAnsi no no no 5 0 AOPLKO+STIXTwoMath Type 1C Custom yes yes yes 70 0 AOPLLO+Lato-Black Type 1C WinAnsi yes yes no 71 0 AOPMJK+STIX-Regular Type 1C Custom yes yes yes 96 0 AOPNIG+STIXTwoText Type 1C Custom yes yes yes 117 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-27 02:41:34 CEST RepresentationInformation: 313086.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-26 14:37:57 CEST Size: 8477187 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'alz13692-supitem-0003' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'alz13692-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'alz13692-supitem-0002' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'alz13692-supitem-0004' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz13692-supitem-0002' cannot be found ID: PDF-HUL-122 Offset: 8475974 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz13692-supitem-0003' cannot be found ID: PDF-HUL-122 Offset: 8475974 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz13692-supitem-0004' cannot be found ID: PDF-HUL-122 Offset: 8475974 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz13692-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 8475974 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Down Syndrome Biobank Consortium: A perspective Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Overview Destination: subsection..1.2.1 Item: Title: 2.2 | Tissue and biofluid processing Destination: subsection..1.2.2 Children: Item: Title: 2.2.1 | Consent process Destination: subsubsection..1.2.2.1 Item: Title: 2.2.2 | Cognitive assessment Destination: subsubsection..1.2.2.2 Item: Title: 2.2.3 | Genetic screening and karyotyping Destination: subsubsection..1.2.2.3 Item: Title: 2.2.4 | Tissue request committee Destination: subsubsection..1.2.2.4 Item: Title: 2.2.5 | Sample storage and distribution Destination: subsubsection..1.2.2.5 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Consortium input Destination: subsection..1.3.1 Item: Title: 3.2 | Consortium output Destination: subsection..1.3.2 Children: Item: Title: 3.2.1 | Neurobiological findings Destination: subsubsection..1.3.2.1 Item: Title: 4 | DISCUSSION Destination: section..1.4 Children: Item: Title: 4.1 | Limitations Destination: subsection..1.4.1 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: CONSENT STATEMENT Destination: section*.8 Item: Title: ORCID Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 1787 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1854 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: AOPKNB+Lato-Italic FontSubset: true FirstChar: 38 LastChar: 146 FontDescriptor: FontName: AOPKNB+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOPMJK+STIX-Regular FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: AOPMJK+STIX-Regular Flags: Symbolic FontBBox: 47, 147, 637, 362 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOPLDP+STIXTwoText-Italic FontSubset: true FirstChar: 2 LastChar: 181 FontDescriptor: FontName: AOPLDP+STIXTwoText-Italic Flags: Symbolic, Italic FontBBox: -893, -367, 1298, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOPNIG+STIXTwoText FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: AOPNIG+STIXTwoText Flags: Symbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOPLKO+STIXTwoMath FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: AOPLKO+STIXTwoMath Flags: Symbolic FontBBox: 43, -40, 658, 558 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AOPLLO+Lato-Black FontSubset: true FirstChar: 49 LastChar: 88 FontDescriptor: FontName: AOPLLO+Lato-Black Flags: Nonsymbolic, ForceBold FontBBox: -83, -179, 1167, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOPJPE+Lato-Regular FontSubset: true FirstChar: 36 LastChar: 243 FontDescriptor: FontName: AOPJPE+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOPKFD+Lato-Bold FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: AOPKFD+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1002/alz.13692 10.1002/alz.13692https://doi.org/10.1002/alz.13692 2024-01-25truealz-journals.onlinelibrary.wiley.com10.1002/alz.13692 alz-journals.onlinelibrary.wiley.comtrue10.1002/alz.136922024-01-25 VoR Pages: Page: Label: 2262 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 114, 624, 120, 632 Destination: 241 Annotation: Subtype: Link Rect: 121, 624, 127, 632 Destination: 241 Annotation: Subtype: Link Rect: 232, 624, 239, 632 Destination: 241 Annotation: Subtype: Link Rect: 349, 624, 356, 632 Destination: 241 Annotation: Subtype: Link Rect: 441, 624, 448, 632 Destination: 241 Annotation: Subtype: Link Rect: 118, 606, 125, 614 Destination: 241 Annotation: Subtype: Link Rect: 256, 606, 262, 614 Destination: 241 Annotation: Subtype: Link Rect: 263, 606, 269, 614 Destination: 241 Annotation: Subtype: Link Rect: 388, 606, 394, 614 Destination: 241 Annotation: Subtype: Link Rect: 498, 606, 505, 614 Destination: 241 Annotation: Subtype: Link Rect: 125, 588, 131, 596 Destination: 241 Annotation: Subtype: Link Rect: 231, 588, 242, 596 Destination: 241 Annotation: Subtype: Link Rect: 363, 588, 375, 596 Destination: 241 Annotation: Subtype: Link Rect: 506, 588, 513, 596 Destination: 241 Annotation: Subtype: Link Rect: 513, 588, 524, 596 Destination: 241 Annotation: Subtype: Link Rect: 171, 570, 183, 578 Destination: 241 Annotation: Subtype: Link Rect: 312, 570, 323, 578 Destination: 241 Annotation: Subtype: Link Rect: 431, 570, 438, 578 Destination: 241 Annotation: Subtype: Link Rect: 119, 552, 131, 560 Destination: 241 Annotation: Subtype: Link Rect: 219, 552, 230, 560 Destination: 241 Annotation: Subtype: Link Rect: 339, 552, 350, 560 Destination: 241 Annotation: Subtype: Link Rect: 509, 552, 515, 560 Destination: 241 Annotation: Subtype: Link Rect: 516, 548, 527, 559 Annotation: Subtype: Link Rect: 64, 220, 169, 228 Annotation: Subtype: Link Rect: 202, 72, 299, 79 Annotation: Subtype: Link Rect: 78, 29, 183, 37 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Thumb: true Page: Label: 2263 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 283, 572, 288, 578 Destination: 147 Annotation: Subtype: Link Rect: 83, 507, 96, 513 Destination: 147 Annotation: Subtype: Link Rect: 178, 468, 183, 474 Destination: 147 Annotation: Subtype: Link Rect: 75, 441, 86, 448 Destination: 147 Annotation: Subtype: Link Rect: 280, 442, 286, 448 Destination: 147 Annotation: Subtype: Link Rect: 158, 300, 163, 306 Destination: 147 Annotation: Subtype: Link Rect: 269, 300, 288, 306 Destination: 147 Annotation: Subtype: Link Rect: 248, 261, 254, 267 Destination: 147 Annotation: Subtype: Link Rect: 269, 209, 288, 215 Destination: 147 Annotation: Subtype: Link Rect: 271, 105, 288, 112 Destination: 147 Annotation: Subtype: Link Rect: 463, 559, 472, 565 Destination: 147 Annotation: Subtype: Link Rect: 532, 480, 550, 487 Destination: 147 Annotation: Subtype: Link Rect: 357, 193, 364, 201 Destination: 82 Annotation: Subtype: Link Rect: 305, 102, 529, 109 Annotation: Subtype: Link Rect: 305, 89, 467, 96 Thumb: true Page: Label: 2264 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 111, 687, 117, 695 Destination: 82 Annotation: Subtype: Link Rect: 262, 470, 271, 476 Destination: 147 Annotation: Subtype: Link Rect: 274, 65, 285, 73 Destination: null Annotation: Subtype: Link Rect: 541, 327, 550, 333 Destination: 147 Annotation: Subtype: Link Rect: 440, 249, 449, 256 Destination: 147 Annotation: Subtype: Link Rect: 403, 210, 411, 217 Destination: 147 Annotation: Subtype: Link Rect: 534, 195, 546, 202 Destination: 93 Annotation: Subtype: Link Rect: 470, 172, 479, 178 Destination: 147 Annotation: Subtype: Link Rect: 511, 130, 523, 138 Destination: 93 Annotation: Subtype: Link Rect: 389, 104, 396, 112 Destination: 93 Thumb: true Page: Label: 2265 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 110, 404, 127, 411 Destination: 147 Annotation: Subtype: Link Rect: 262, 363, 269, 371 Destination: null Annotation: Subtype: Link Rect: 66, 208, 73, 216 Destination: 82 Annotation: Subtype: Link Rect: 178, 80, 202, 87 Destination: 147 Annotation: Subtype: Link Rect: 341, 405, 350, 411 Destination: 155 Annotation: Subtype: Link Rect: 321, 388, 546, 396 Annotation: Subtype: Link Rect: 370, 314, 379, 321 Destination: 155 Annotation: Subtype: Link Rect: 385, 262, 394, 269 Destination: 155 Thumb: true Page: Label: 2266 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 440, 690, 449, 696 Destination: 147 Annotation: Subtype: Link Rect: 385, 91, 392, 99 Destination: 82 Thumb: true Page: Label: 2267 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 116, 481, 122, 489 Destination: 82 Annotation: Subtype: Link Rect: 70, 390, 81, 398 Destination: null Annotation: Subtype: Link Rect: 171, 287, 178, 295 Destination: 103 Annotation: Subtype: Link Rect: 486, 598, 492, 605 Destination: null Annotation: Subtype: Link Rect: 356, 354, 398, 361 Destination: 147 Annotation: Subtype: Link Rect: 305, 286, 539, 293 Annotation: Subtype: Link Rect: 305, 273, 441, 280 Annotation: Subtype: Link Rect: 466, 159, 480, 166 Destination: 147 Thumb: true Page: Label: 2268 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 243, 675, 260, 682 Destination: 147 Annotation: Subtype: Link Rect: 116, 660, 133, 668 Destination: 135 Annotation: Subtype: Link Rect: 135, 660, 147, 668 Destination: 135 Annotation: Subtype: Link Rect: 149, 660, 161, 668 Destination: 135 Annotation: Subtype: Link Rect: 163, 660, 176, 668 Destination: 135 Annotation: Subtype: Link Rect: 187, 595, 194, 603 Destination: 142 Annotation: Subtype: Link Rect: 222, 481, 231, 488 Destination: 155 Annotation: Subtype: Link Rect: 157, 404, 166, 410 Destination: 155 Annotation: Subtype: Link Rect: 246, 378, 265, 384 Destination: 155 Annotation: Subtype: Link Rect: 248, 364, 288, 371 Destination: 147 Annotation: Subtype: Link Rect: 190, 351, 207, 358 Destination: 155 Annotation: Subtype: Link Rect: 457, 378, 496, 385 Destination: 147 Annotation: Subtype: Link Rect: 453, 107, 462, 113 Destination: 155 Thumb: true Page: Label: 2269 Sequence: 8 Thumb: true Page: Label: 2270 Sequence: 9 Thumb: true Page: Label: 2271 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 104, 703, 113, 709 Destination: 155 Annotation: Subtype: Link Rect: 98, 320, 180, 329 Destination: null Annotation: Subtype: Link Rect: 126, 189, 137, 191 Annotation: Subtype: Link Rect: 136, 188, 282, 195 Thumb: true Page: Label: 2272 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 132, 568, 204, 575 Annotation: Subtype: Link Rect: 451, 359, 549, 366 Annotation: Subtype: Link Rect: 318, 194, 440, 201 Thumb: true Checksum: 8d987b3b Type: CRC32 Checksum: 50b50a694e4e654ef5a5bb0a6a28261e Type: MD5 Checksum: 5aa906e1ea5e1b86f4ff93a94b8eb0525d6be220 Type: SHA-1 Checksum: 6a9ba954307f253c95ae0fa8549a7bee9e8cc87ea7684ee2b242f9ee591d8771 Type: SHA-256