9649addce7cbca1ffc6c58f02e665032  313091.pdf
bdc33d59f4689bf8036985736ca7247d39db0773  313091.pdf
2ef1afeed817c48cc6ea379390eaa9c4c3e984771b4854eca24e1675fdfd0afd  313091.pdf

Title:           A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
Subject:         Scientific Reports, https://doi.org/10.1038/s41598-024-53310-x
Author:          Francesca Minnai 
Creator:         Springer
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Tue Feb  6 04:31:54 2024 CET
ModDate:         Tue Feb  6 05:57:15 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           14
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       1984812 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LDVGEA+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    429  0
Corbel-Bold2                         TrueType          WinAnsi          yes no  yes    430  0
HEAMZA+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     62  0
Corbel-BoldItalic                    TrueType          WinAnsi          yes no  yes    431  0
Corbel2                              TrueType          WinAnsi          yes no  yes     63  0
ZPFVRQ+Corbel                        CID TrueType      Identity-H       yes yes yes     64  0
Corbel3                              CID TrueType      Identity-H       yes no  yes    466  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     60  0
MinionPro-It                         Type 1C           Custom           yes no  yes     61  0
Corbel4                              TrueType          WinAnsi          yes no  yes    115  0
MinionPro-Bold                       Type 1C           Custom           yes no  yes    173  0
NTYNQA+MinionPro-BoldIt              Type 1C           WinAnsi          yes yes yes    193  0
EFHXEG+Code2000                      CID TrueType      Identity-H       yes yes yes    228  0
JKUBWW+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    229  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-06-28 02:39:42 CEST
 RepresentationInformation: 313091.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-06-27 12:56:56 CEST
  Size: 1984812
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 500
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
      Children: 
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Case series
         Item: 
          Title: Survival analysis
         Item: 
          Title: Genotyping data quality check, principal component analysis, and imputation
         Item: 
          Title: Genome-wide survival analysis
         Item: 
          Title: Functional analyses
         Item: 
          Title: Ethical approval and informed consent
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Age, sex, and period of infection are associated with COVID-19 patient survival
         Item: 
          Title: Germline variants are associated with COVID-19 overall survival 60 days after infection
         Item: 
          Title: Variants associated with COVID-19 patient survival are involved in immune or lung functions
       Item: 
        Title: Discussion
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
   Info: 
    Title: A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
    Author: Francesca Minnai 
    Subject: Scientific Reports, https://doi.org/10.1038/s41598-024-53310-x
    Creator: Springer
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Feb 06 05:01:54 CET 2024
    ModDate: Tue Feb 06 05:57:15 CET 2024
   ID: 0x28e6a3b53a327c64aaea3bf6442673fc, 0x85b835e4382a554eff34cde118593f34
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2008
      ImageHeight: 953
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1937
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 666
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ZPFVRQ+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EFHXEG+Code2000
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: HEAMZA+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NTYNQA+MinionPro-BoldIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: NTYNQA+MinionPro-BoldIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -230, -360, 1684, 1032
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LDVGEA+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LDVGEA+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: JKUBWW+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JKUBWW+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Corbel-Bold2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Corbel2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Corbel-BoldItalic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel-BoldItalic
       Flags: Nonsymbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: JPMBLW+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: JPMBLW+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: HEAMZA+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HEAMZA+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
     Font: 
      BaseFont: EFHXEG+Code2000
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: EFHXEG+Code2000
       Flags: Serif, Symbolic
       FontBBox: -1111, -295, 2107, 977
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2024-02-06T09:01:54+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2024-02-06T05:57:15+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-02-06T05:57:15+01:00</xmp:MetadataDate>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1038/s41598-024-53310-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group UK</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, https://doi.org/10.1038/s41598-024-53310-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Francesca Minnai </rdf:li>
               <rdf:li>Filippo Biscarini </rdf:li>
               <rdf:li>Martina Esposito </rdf:li>
               <rdf:li>Tommaso A. Dragani </rdf:li>
               <rdf:li>Luis Bujanda </rdf:li>
               <rdf:li>Souad Rahmouni </rdf:li>
               <rdf:li>Marta E. Alarcón-Riquelme </rdf:li>
               <rdf:li>David Bernardo </rdf:li>
               <rdf:li>Elena Carnero-Montoro </rdf:li>
               <rdf:li>Maria Buti </rdf:li>
               <rdf:li>Hugo Zeberg </rdf:li>
               <rdf:li>Rosanna Asselta </rdf:li>
               <rdf:li>Manuel Romero-Gómez </rdf:li>
               <rdf:li>Francesca Mari </rdf:li>
               <rdf:li>Sergio Daga </rdf:li>
               <rdf:li>Ilaria Meloni </rdf:li>
               <rdf:li>Giulia Brunelli </rdf:li>
               <rdf:li>Mirjam Lista </rdf:li>
               <rdf:li>Debora Maffeo </rdf:li>
               <rdf:li>Elena Pasquinelli </rdf:li>
               <rdf:li>Enrica Antolini </rdf:li>
               <rdf:li>Simona Letizia Basso </rdf:li>
               <rdf:li>Samantha Minetto </rdf:li>
               <rdf:li>Giulia Rollo </rdf:li>
               <rdf:li>Angela Rina </rdf:li>
               <rdf:li>Martina Rozza </rdf:li>
               <rdf:li>Rossella Tita </rdf:li>
               <rdf:li>Maria Antonietta Mencarelli </rdf:li>
               <rdf:li>Caterina Lo Rizzo </rdf:li>
               <rdf:li>Anna Maria Pinto </rdf:li>
               <rdf:li>Francesca Ariani </rdf:li>
               <rdf:li>Francesca Montagnani </rdf:li>
               <rdf:li>Mario Tumbarello </rdf:li>
               <rdf:li>Ilaria Rancan </rdf:li>
               <rdf:li>Massimiliano Fabbiani </rdf:li>
               <rdf:li>Paolo Cameli </rdf:li>
               <rdf:li>David Bennett </rdf:li>
               <rdf:li>Federico Anedda </rdf:li>
               <rdf:li>Simona Marcantonio </rdf:li>
               <rdf:li>Sabino Scolletta </rdf:li>
               <rdf:li>Federico Franchi </rdf:li>
               <rdf:li>Maria Antonietta Mazzei </rdf:li>
               <rdf:li>Susanna Guerrini </rdf:li>
               <rdf:li>Edoardo Conticini </rdf:li>
               <rdf:li>Luca Cantarini </rdf:li>
               <rdf:li>Bruno Frediani </rdf:li>
               <rdf:li>Danilo Tacconi </rdf:li>
               <rdf:li>Chiara Spertilli Raffaelli </rdf:li>
               <rdf:li>Arianna Emiliozzi </rdf:li>
               <rdf:li>Marco Feri </rdf:li>
               <rdf:li>Alice Donati </rdf:li>
               <rdf:li>Raffaele Scala </rdf:li>
               <rdf:li>Luca Guidelli </rdf:li>
               <rdf:li>Genni Spargi </rdf:li>
               <rdf:li>Marta Corridi </rdf:li>
               <rdf:li>Cesira Nencioni </rdf:li>
               <rdf:li>Leonardo Croci </rdf:li>
               <rdf:li>Gian Piero Caldarelli </rdf:li>
               <rdf:li>Davide Romani </rdf:li>
               <rdf:li>Paolo Piacentini </rdf:li>
               <rdf:li>Maria Bandini </rdf:li>
               <rdf:li>Elena Desanctis </rdf:li>
               <rdf:li>Silvia Cappelli </rdf:li>
               <rdf:li>Anna Canaccini </rdf:li>
               <rdf:li>Agnese Verzuri </rdf:li>
               <rdf:li>Valentina Anemoli </rdf:li>
               <rdf:li>Agostino Ognibene </rdf:li>
               <rdf:li>Maria Lorubbio </rdf:li>
               <rdf:li>Alessandro Pancrazzi </rdf:li>
               <rdf:li>Massimo Vaghi </rdf:li>
               <rdf:li>Antonella D.’Arminio Monforte </rdf:li>
               <rdf:li>Federica Gaia Miraglia </rdf:li>
               <rdf:li>Mario U. Mondelli </rdf:li>
               <rdf:li>Stefania Mantovani </rdf:li>
               <rdf:li>Raffaele Bruno </rdf:li>
               <rdf:li>Marco Vecchia </rdf:li>
               <rdf:li>Marcello Maffezzoni </rdf:li>
               <rdf:li>Enrico Martinelli </rdf:li>
               <rdf:li>Massimo Girardis </rdf:li>
               <rdf:li>Stefano Busani </rdf:li>
               <rdf:li>Sophie Venturelli </rdf:li>
               <rdf:li>Andrea Cossarizza </rdf:li>
               <rdf:li>Andrea Antinori </rdf:li>
               <rdf:li>Alessandra Vergori </rdf:li>
               <rdf:li>Stefano Rusconi </rdf:li>
               <rdf:li>Matteo Siano </rdf:li>
               <rdf:li>Arianna Gabrieli </rdf:li>
               <rdf:li>Agostino Riva </rdf:li>
               <rdf:li>Daniela Francisci </rdf:li>
               <rdf:li>Elisabetta Schiaroli </rdf:li>
               <rdf:li>Carlo Pallotto </rdf:li>
               <rdf:li>Saverio Giuseppe Parisi </rdf:li>
               <rdf:li>Monica Basso </rdf:li>
               <rdf:li>Sandro Panese </rdf:li>
               <rdf:li>Stefano Baratti </rdf:li>
               <rdf:li>Pier Giorgio Scotton </rdf:li>
               <rdf:li>Francesca Andretta </rdf:li>
               <rdf:li>Mario Giobbia </rdf:li>
               <rdf:li>Renzo Scaggiante </rdf:li>
               <rdf:li>Francesca Gatti </rdf:li>
               <rdf:li>Francesco Castelli </rdf:li>
               <rdf:li>Eugenia Quiros-Roldan </rdf:li>
               <rdf:li>Melania Degli Antoni </rdf:li>
               <rdf:li>Isabella Zanella </rdf:li>
               <rdf:li>Matteo della Monica </rdf:li>
               <rdf:li>Carmelo Piscopo </rdf:li>
               <rdf:li>Mario Capasso </rdf:li>
               <rdf:li>Roberta Russo </rdf:li>
               <rdf:li>Immacolata Andolfo </rdf:li>
               <rdf:li>Achille Iolascon </rdf:li>
               <rdf:li>Giuseppe Fiorentino </rdf:li>
               <rdf:li>Massimo Carella </rdf:li>
               <rdf:li>Marco Castori </rdf:li>
               <rdf:li>Giuseppe Merla </rdf:li>
               <rdf:li>Gabriella Maria Squeo </rdf:li>
               <rdf:li>Filippo Aucella </rdf:li>
               <rdf:li>Pamela Raggi </rdf:li>
               <rdf:li>Rita Perna </rdf:li>
               <rdf:li>Matteo Bassetti </rdf:li>
               <rdf:li>Antonio Di Biagio</rdf:li>
               <rdf:li>Maurizio Sanguinetti </rdf:li>
               <rdf:li>Luca Masucci </rdf:li>
               <rdf:li>Alessandra Guarnaccia </rdf:li>
               <rdf:li>Serafina Valente </rdf:li>
               <rdf:li>Alex Di Florio</rdf:li>
               <rdf:li>Marco Mandalà </rdf:li>
               <rdf:li>Alessia Giorli </rdf:li>
               <rdf:li>Lorenzo Salerni </rdf:li>
               <rdf:li>Patrizia Zucchi </rdf:li>
               <rdf:li>Pierpaolo Parravicini </rdf:li>
               <rdf:li>Elisabetta Menatti </rdf:li>
               <rdf:li>Tullio Trotta </rdf:li>
               <rdf:li>Ferdinando Giannattasio </rdf:li>
               <rdf:li>Gabriella Coiro </rdf:li>
               <rdf:li>Gianluca Lacerenza </rdf:li>
               <rdf:li>Cristina Mussini </rdf:li>
               <rdf:li>Luisa Tavecchia </rdf:li>
               <rdf:li>Lia Crotti </rdf:li>
               <rdf:li>Gianfranco Parati </rdf:li>
               <rdf:li>Roberto Menè </rdf:li>
               <rdf:li>Maurizio Sanarico </rdf:li>
               <rdf:li>Marco Gori </rdf:li>
               <rdf:li>Francesco Raimondi </rdf:li>
               <rdf:li>Alessandra Stella </rdf:li>
               <rdf:li>Filippo Biscarini </rdf:li>
               <rdf:li>Tiziana Bachetti </rdf:li>
               <rdf:li>Maria Teresa La Rovere</rdf:li>
               <rdf:li>Maurizio Bussotti </rdf:li>
               <rdf:li>Serena Ludovisi </rdf:li>
               <rdf:li>Katia Capitani </rdf:li>
               <rdf:li>Simona Dei </rdf:li>
               <rdf:li>Sabrina Ravaglia </rdf:li>
               <rdf:li>Annarita Giliberti </rdf:li>
               <rdf:li>Giulia Gori </rdf:li>
               <rdf:li>Rosangela Artuso </rdf:li>
               <rdf:li>Elena Andreucci </rdf:li>
               <rdf:li>Antonio Perrella </rdf:li>
               <rdf:li>Francesco Bianchi </rdf:li>
               <rdf:li>Paola Bergomi </rdf:li>
               <rdf:li>Emanuele Catena </rdf:li>
               <rdf:li>Riccardo Colombo </rdf:li>
               <rdf:li>Sauro Luchi </rdf:li>
               <rdf:li>Giovanna Morelli </rdf:li>
               <rdf:li>Paola Petrocelli </rdf:li>
               <rdf:li>Sarah Iacopini </rdf:li>
               <rdf:li>Sara Modica </rdf:li>
               <rdf:li>Silvia Baroni </rdf:li>
               <rdf:li>Giulia Micheli </rdf:li>
               <rdf:li>Marco Falcone </rdf:li>
               <rdf:li>Donato Urso </rdf:li>
               <rdf:li>Giusy Tiseo </rdf:li>
               <rdf:li>Tommaso Matucci </rdf:li>
               <rdf:li>Alice Pulcinelli </rdf:li>
               <rdf:li>Davide Grassi </rdf:li>
               <rdf:li>Claudio Ferri </rdf:li>
               <rdf:li>Franco Marinangeli </rdf:li>
               <rdf:li>Francesco Brancati </rdf:li>
               <rdf:li>Antonella Vincenti </rdf:li>
               <rdf:li>Valentina Borgo </rdf:li>
               <rdf:li>Stefania Lombardi </rdf:li>
               <rdf:li>Mirco Lenzi </rdf:li>
               <rdf:li>Massimo Antonio Di Pietro</rdf:li>
               <rdf:li>Letizia Attala </rdf:li>
               <rdf:li>Cecilia Costa </rdf:li>
               <rdf:li>Andrea Gabbuti </rdf:li>
               <rdf:li>Alessio Bellucci </rdf:li>
               <rdf:li>Marta Colaneri </rdf:li>
               <rdf:li>Patrizia Casprini </rdf:li>
               <rdf:li>Cristoforo Pomara </rdf:li>
               <rdf:li>Massimiliano Esposito </rdf:li>
               <rdf:li>Roberto Leoncini </rdf:li>
               <rdf:li>Michele Cirianni </rdf:li>
               <rdf:li>Lucrezia Galasso </rdf:li>
               <rdf:li>Marco Antonio Bellini </rdf:li>
               <rdf:li>Chiara Gabbi </rdf:li>
               <rdf:li>Nicola Picchiotti </rdf:li>
               <rdf:li>Simone Furini </rdf:li>
               <rdf:li>Elisabetta Pelo </rdf:li>
               <rdf:li>Barbara Minuti </rdf:li>
               <rdf:li>Francesca Gerundino </rdf:li>
               <rdf:li>Chiara Lazzeri </rdf:li>
               <rdf:li>Arianna Vecchi </rdf:li>
               <rdf:li>Leila Bianchi </rdf:li>
               <rdf:li>Elisabetta Venturini </rdf:li>
               <rdf:li>Carlotta Montagnani </rdf:li>
               <rdf:li>Elena Chiappini </rdf:li>
               <rdf:li>Cristina Beltrami </rdf:li>
               <rdf:li>Luisa Galli </rdf:li>
               <rdf:li>Israel Fernandez-Cadenas </rdf:li>
               <rdf:li>Chiara Fallerini </rdf:li>
               <rdf:li>Kristina Zguro </rdf:li>
               <rdf:li>Susanna Croci </rdf:li>
               <rdf:li>Margherita Baldassarri </rdf:li>
               <rdf:li>Mirella Bruttini </rdf:li>
               <rdf:li>Simone Furini </rdf:li>
               <rdf:li>Alessandra Renieri </rdf:li>
               <rdf:li>Francesca Colombo </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1038/s41598-024-53310-x</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1038/s41598-024-53310-x</prism:url>
         <prism:doi>10.1038/s41598-024-53310-x</prism:doi>
         <prism:issn>2045-2322</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1038/s41598-024-53310-x</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:f930b700-18ab-4ba6-a27e-683798479bae</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:a1f16ccf-e5af-47a6-9ac3-4b96eb485775</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:99d00c10-3c9c-452e-8cb3-1bf5d0816758</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-02-06T09:03:16+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:7f954817-9fc2-49b0-9667-db1190c53508</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-02-06T09:04:02+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Francesca Colombo</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2015-4317</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 520, 439, 533, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 481, 675, 556, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 351, 683, 354, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 357, 683, 360, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 349, 673, 352, 660
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 353, 673, 356, 660
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 402, 663, 404, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 406, 663, 409, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 187, 633, 190, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 335, 603, 338, 590
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 509, 573, 514, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 189, 563, 195, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 198, 563, 204, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 295, 563, 300, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 327, 329, 332, 316
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 343, 319, 346, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 433, 319, 439, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 414, 279, 420, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 221, 269, 226, 256
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 246, 217, 366, 204
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 207, 417, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 546, 137, 552, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 336, 87, 341, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 292, 57, 298, 44
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 403, 57, 409, 44
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 488, 57, 493, 44
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 734, 225, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 419, 734, 425, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 393, 662, 396, 650
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 282, 642, 288, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 306, 632, 312, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 230, 572, 357, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 188, 563, 191, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 499, 532, 501, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 420, 460, 426, 448
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 431, 460, 554, 448
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 451, 173, 438
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 430, 253, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 425, 410, 431, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 193, 370, 199, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 299, 350, 304, 338
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 548, 320, 554, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 544, 96, 548, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 468, 634, 471, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 197, 624, 201, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 456, 604, 458, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 253, 504, 257, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 384, 342, 387, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 455, 312, 459, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 222, 212, 226, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 539, 152, 543, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 358, 132, 361, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 229, 360, 235, 348
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
      Annotation: 
       Subtype: Link
       Rect: 256, 260, 261, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 545, 170, 551, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 546, 150, 552, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 539, 140, 545, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 546, 140, 552, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 259, 80, 265, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 253, 86, 259, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 351, 289, 339
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 353, 311, 359, 299
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 186, 261, 192, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 501, 241, 506, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 546, 211, 552, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 431, 161, 436, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 244
      Annotation: 
       Subtype: Link
       Rect: 532, 71, 535, 59
       Flags: Print
       AppearanceDictionary: true
       Destination: 209
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 184, 317, 318, 307
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 224, 266, 358, 256
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 532, 258, 554, 247
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 249, 281, 239
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 194, 198, 326, 188
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 499, 572, 554, 562
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 563, 246, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 547, 531, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 444, 504, 554, 494
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 274, 462, 396, 451
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 532, 419, 554, 409
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 410, 283, 400
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 499, 87, 554, 75
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 77, 260, 65
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 351, 734, 443, 722
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 358, 624, 517, 612
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
  Checksum: 90397d6d
   Type: CRC32
  Checksum: 9649addce7cbca1ffc6c58f02e665032
   Type: MD5
  Checksum: bdc33d59f4689bf8036985736ca7247d39db0773
   Type: SHA-1
  Checksum: 2ef1afeed817c48cc6ea379390eaa9c4c3e984771b4854eca24e1675fdfd0afd
   Type: SHA-256