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found ID: PDF-HUL-122 Offset: 574048 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 574048 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 600 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Progressive systemic inflammation precedes decompensation in compensated cirrhosis Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Patients and methods Destination: flink2 Children: Item: Title: Patients Destination: slink1 Item: Title: Study design Destination: slink2 Item: Title: Sample analysis Destination: slink3 Item: Title: Statistical analysis Destination: slink4 Item: Title: Results Destination: flink3 Children: Item: Title: Patients and follow-up Destination: slink5 Item: Title: Peripheral blood biomarkers Destination: slink6 Children: Item: Title: Systemic inflammation and macrophage activation markers Destination: thirlink1 Item: Title: Intestinal barrier dysfunction and bacterial translocation markers Destination: thirlink2 Item: Title: Correlations between biomarkers Destination: thirlink3 Item: Title: NSBBs and HVPG response at 1 year Destination: slink7 Item: Title: Discussion Destination: flink4 Item: Title: Abbreviations Destination: flink5 Item: Title: Financial support Destination: flink6 Item: Title: Conflicts of interest Destination: flink7 Item: Title: Authors’ contribution Destination: flink8 Item: Title: Data availability statement Destination: flink9 Item: Title: Supplementary data Destination: flink10 Item: Title: References Destination: blink1 Info: Title: Progressive systemic inflammation precedes decompensation in compensated cirrhosis Author: Rubén Sánchez-Aldehuelo Subject: Journal of Hepatology, 7 (2025) 101231. doi:10.1016/j.jhepr.2024.101231 Creator: Elsevier 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Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EDDCBG+AdvOTf0129623+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: EDDCBG+AdvOTf0129623+20 Flags: Nonsymbolic FontBBox: -156, -145, 1072, 718 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.jhepr.2024.101231 Progressive systemic inflammation precedes decompensation in compensated cirrhosis Rubén Sánchez-Aldehuelo Càndid Villanueva Joan Genescà Juan Carlos García-Pagán Elisa Castillo José Luis Calleja Carles Aracil Rafael Bañares Luis Téllez Lorena Paule Rosa María Morillas María Poca Beatriz Peñas Salvador Augustin Juan G. Abraldes Edilmar Alvarado-Tapias Jaume Bosch Agustín Albillos cytokine bacterial translocation portal hypertension chronic advanced liver disease immunity Journal of Hepatology, 7 (2025) 101231. doi:10.1016/j.jhepr.2024.101231 The Authors journal Journal of Hepatology © 2024 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). 2589-5559 7 2 February 2025 101231 101231 10.1016/j.jhepr.2024.101231 https://doi.org/10.1016/j.jhepr.2024.101231 2010-04-23 true 10.1016/j.jhepr.2024.101231 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.jhepr.2024.101231 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2025-02-05T01:56:45+05:30 2025-02-05T09:00:22+05:30 2025-02-05T09:00:22+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:845d5bc3-51b6-4867-830c-aad5c1ab89c8 uuid:c6df8340-875d-4d34-8c57-65075bafdd17 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 42, 585, 124, 593 Annotation: Subtype: Link Rect: 42, 46, 177, 53 Annotation: Subtype: Link Rect: 68, 24, 205, 31 Annotation: Subtype: Link Rect: 307, 781, 320, 789 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 138, 648, 142, 656 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