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Patients were randomized within the first 24 h of presentation to receive either colchicine or placebo, with loading dose of 2 mg, followed by 0.5 mg every 12 h for 8 weeks. Results: A total of 278 patients [median age 75 years, LVEF 40%, baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) 4262 pg/mL] were randomized to colchicine (n = 141) or placebo (n = 137) Keywords: Heart failure; Colchicine; Inflammation; Acute; Randomized controlled trial Author: Domingo Pascual-Figal Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Fri Nov 22 18:18:48 2024 CET ModDate: Tue Nov 26 14:02:28 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1181418 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OJYJXE+GillSansNova-Book CID TrueType Identity-H yes yes yes 1202 0 UTSYVO+GillSansNova-Bold CID TrueType Identity-H yes yes yes 1207 0 QFYHZF+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 1212 0 UMPYZB+GillSansNova-BoldItalic CID TrueType Identity-H yes yes yes 1217 0 AKCPKI+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 1222 0 KESBJD+STIXGeneral-Regular Type 1C Custom yes yes yes 1227 0 NYECAB+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 129 0 RTEBNU+GillSansNova-Book Type 1C Custom yes yes yes 12 0 RTEBNU+GillSansNova-Bold Type 1C WinAnsi yes yes yes 17 0 RTEBNU+GillSansNova-Medium Type 1C Custom yes yes no 21 0 RTEBNU+GillSansNova-Book Type 1C Custom yes yes no 25 0 QRXPBD+STIXGeneral-Bold Type 1C Custom yes yes yes 164 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-30 02:09:11 CEST RepresentationInformation: ehae538.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-29 18:45:46 CEST Size: 1181418 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - 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referenced object 'affehae538-aff6' cannot be found ID: PDF-HUL-122 Offset: 943542 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'affehae538-aff13' cannot be found ID: PDF-HUL-122 Offset: 943542 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1319 FreeObjects: 6 IncrementalUpdates: 6 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Colchicine in acutely decompensated heart failure: the COLICA trial Destination: head1 Children: Item: Title: Introduction Destination: secehae538-s1 Item: Title: Methods Destination: secehae538-s2 Children: Item: Title: Trial design Destination: secehae538-s2.1 Item: Title: Trial population Destination: secehae538-s2.2 Item: Title: Trial procedures Destination: secehae538-s2.3 Item: Title: Trial endpoints Destination: secehae538-s2.4 Item: Title: Statistical analysis Destination: secehae538-s2.5 Item: Title: Results Destination: secehae538-s3 Children: Item: Title: Study population Destination: secehae538-s3.1 Item: Title: Trial treatment Destination: secehae538-s3.2 Item: Title: Primary efficacy outcome Destination: secehae538-s3.3 Item: Title: Secondary efficacy outcomes Destination: secehae538-s3.4 Item: Title: Concomitant guideline-directed medical therapy Destination: secehae538-s3.5 Item: Title: Discussion Destination: secehae538-s4 Item: Title: Acknowledgements Destination: acknow Item: Title: Supplementary data Destination: secehae538-s5 Item: Title: Declarations Destination: secehae538-s6 Children: Item: Title: Disclosure of Interest Destination: secehae538-s6.1 Item: Title: Data Availability Destination: secehae538-s6.2 Item: Title: Funding Destination: secehae538-s6.3 Item: Title: Ethical Approval Destination: secehae538-s6.4 Item: Title: Pre-registered Clinical Trial Number Destination: secehae538-s6.5 Item: Title: References Destination: reflist Info: Title: Colchicine in acutely decompensated heart failure: the COLICA trial Author: Domingo Pascual-Figal Subject: DOI: 10.1093/eurheartj/ehae538; European Heart Journal, 45, 45, 2024-08-30.; Abstract: Background and Aims: Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other ca爀搀椀漀瘀愀猀挀甀氀愀爀 挀漀渀搀椀琀椀漀渀猀 挀栀愀爀愀挀琀攀爀椀稀攀搀 戀礀 椀渀昀氀愀洀洀愀琀漀爀礀 愀挀琀椀瘀愀琀椀漀渀Ⰰ 戀甀琀 栀愀猀 渀攀瘀攀爀 戀攀攀渀 攀瘀愀氀甀愀琀攀搀 椀渀 琀栀攀 猀攀琀琀椀渀最 漀昀 䄀䠀䘀⸀ 䴀攀琀栀漀搀猀㨀 his multicenter, randomized, double-blind, and placebo-controlled trial included patients with AHF, requiring ≥40 mg of intrave渀漀甀猀 昀甀爀漀猀攀洀椀搀攀Ⰰ 爀攀最愀爀搀氀攀猀猀 漀昀 琀栀攀椀爀 氀攀昀琀 瘀攀渀琀爀椀挀甀氀愀爀 攀樀攀挀琀椀漀渀 昀爀愀挀琀椀漀渀 䰀嘀䔀䘀 愀渀搀 椀渀瀀愀琀椀攀渀琀 漀爀 漀甀琀瀀愀琀椀攀渀琀 猀攀琀琀椀渀最⸀ 倀愀琀椀攀渀琀猀 眀re randomized within the first 24 h of presentation to receive either colchicine or placebo, with loading dose of 2 mg, followe搀 戀礀 　⸀㔠Ԁ洀最 攀瘀攀爀礀 ㄀㈠Ԁ栀 昀漀爀 㠠Ԁ眀攀攀欀猀⸀ 刀攀猀甀氀琀猀㨀 䄀 琀漀琀愀氀 漀昀 ㈀㜀㠀 瀀愀琀椀攀渀琀猀 嬀洀攀搀椀愀渀 愀最攀 㜀㔠Ԁ礀攀愀爀猀Ⰰ 䰀嘀䔀䘀 㐀　─Ⰰ 戀愀猀攀氀椀渀攀 一ⴀ琀攀爀洀椀渀愀氀 瀀爀漀ⴀ䈀ⴀype natriuretic peptide (NT-proBNP) 4262 pg/mL] were randomized to colchicine (n = 141) or placebo (n = 137) Keywords: Heart failure; Colchicine; Inflammation; Acute; Randomized controlled trial Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Fri Nov 22 18:48:48 CET 2024 ModDate: Tue Nov 26 14:32:28 CET 2024 ID: 0x9c66b75153a163a0d478cd83e9b0a22f, 0x596b9ff34591c441bf28f9218e89bc44 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1266 ImageHeight: 1051 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 866 ImageHeight: 593 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 900 ImageHeight: 1215 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1266 ImageHeight: 641 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: UMPYZB+GillSansNova-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: NYECAB+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: OJYJXE+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: AKCPKI+GillSansNova-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: UTSYVO+GillSansNova-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: QFYHZF+GillSansNova-BookItalic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: QRXPBD+STIXGeneral-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: QRXPBD+STIXGeneral-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1030, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KESBJD+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: KESBJD+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: UMPYZB+GillSansNova-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UMPYZB+GillSansNova-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -404, -250, 1219, 960 FontFile2: true Font: BaseFont: NYECAB+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NYECAB+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: OJYJXE+GillSansNova-Book CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OJYJXE+GillSansNova-Book Flags: Nonsymbolic FontBBox: -420, -251, 1219, 950 FontFile2: true Font: BaseFont: AKCPKI+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AKCPKI+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true Font: BaseFont: UTSYVO+GillSansNova-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UTSYVO+GillSansNova-Bold Flags: Nonsymbolic, ForceBold FontBBox: -476, -276, 1276, 961 FontFile2: true Font: BaseFont: QFYHZF+GillSansNova-BookItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QFYHZF+GillSansNova-BookItalic Flags: Nonsymbolic, Italic FontBBox: -316, -235, 1219, 950 FontFile2: true XMP: uuid:6b0e06bd-27b9-4ad8-a9b8-143c3437c383 uuid:7C2291DC-2BC1-DD7F-2C73-CEFBF5BCFD17 True Heart failure; Colchicine; Inflammation; Acute; Randomized controlled trial PDFlib+PDI 9.0.7p3 (C++/Win64) application/pdf 10.1093/eurheartj/ehae538 en Oxford University Press Colchicine in acutely decompensated heart failure: the COLICA trial Domingo Pascual-Figal Julio Núñez Maria T. Pérez-Martínez José Ramón González-Juanatey Mikel Taibo-Urquia Pau Llàcer-Iborra Juan Delgado Sandra Villar Sonia Mirabet Alberto Aimo Alejandro Riquelme-Pérez Manuel Anguita-Sánchez Manuel Martínez-Sellés Jose A. Noguera-Velasco Borja Ibáñez Antoni Bayés-Genís DOI: 10.1093/eurheartj/ehae538; European Heart Journal, 45, 45, 2024-08-30.; Abstract: Background and Aims: Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by inflammatory activation, but has never been evaluated in the setting of AHF. Methods: This multicenter, randomized, double-blind, and placebo-controlled trial included patients with AHF, requiring ≥40 mg of intravenous furosemide, regardless of their left ventricular ejection fraction (LVEF) and inpatient or outpatient setting. Patients were randomized within the first 24 h of presentation to receive either colchicine or placebo, with loading dose of 2 mg, followed by 0.5 mg every 12 h for 8 weeks. Results: A total of 278 patients [median age 75 years, LVEF 40%, baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) 4262 pg/mL] were randomized to colchicine (n = 141) or placebo (n = 137) © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. Heart failure Colchicine Inflammation Acute Randomized controlled trial Journal European Heart Journal © The Author(s) 2024. 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