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Title:           Risk of metachronous neoplasia in early-onset colorectal cancer: meta-analysis
Subject:         DOI: 10.1093/bjsopen/zrae092; BJS Open, 8, 5, 2024-09-04.; Abstract:  Background: Metachronous colorectal cancer refers to patients developing a second colorectal neoplasia diagnosed at least 6 months after the initial cancer diagnosis, excluding recurrence. The aim of this systematic review is to assess the incidence of metachronous colorectal cancer in early-onset colorectal cancer (defined as age at diagnosis of less than 50 years) and to identify risk factors. Methods: This is a systematic review and meta-analysis performed following the PRISMA statement and registered on PROSPERO. The literature search was conducted in PubMed and Embase. Only studies involving patients with early-onset colorectal cancer (less than 50 years old) providing data on metachronous colorectal cancer were included in the analysis. The primary endpoint was the risk of metachronous colorectal cancer in patients with early-onset colorectal cancer. Secondary endpoints were association with Lynch syndrome, family history and microsatellite instability. Results: Sixteen studies met the inclusion criteria. The incidence of metachronous colorectal cancer was 2.6% (95% c.i. 2.287–3.007). The risk of developing metachronous colorectal cancer in early-onset colorectal cancer versus non-early-onset colorectal cancer patients demonstrated an OR of 0.93 (95% c.i. 0.760–1.141). The incidence of metachronous colorectal cancer in patients with Lynch syndrome was 18.43% (95% c.i. 15.396–21.780), and in patients with family history 10.52% (95% c.i. 5.555–17.659). The proportion of metachronous colorectal cancer tumours in the microsatellite instability population was 19.7% (95% c.i. 13.583–27.2422). Conclusion: The risk of metachronous colorectal cancer in patients with early-onset colorectal cancer is comparable to those with advanced age, but it is higher in patients with Lynch syndrome, family history and microsatellite instability. This meta-analysis demonstrates the need to personalize the manageme
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      Title: Risk of metachronous neoplasia in early-onset colorectal cancer: meta-analysis
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       Item: 
        Title: Introduction
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       Item: 
        Title: Methods
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         Item: 
          Title: Search strategy and data sources
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         Item: 
          Title: Inclusion and exclusion criteria
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         Item: 
          Title: Endpoints
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         Item: 
          Title: Statistical analysis
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          Title: Risk-of-bias assessment and quality of the studies
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        Title: Results
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         Item: 
          Title: mCRC in patients with EOCRC
          Destination: seczrae092-s2.1
         Item: 
          Title: Risk of mCRC in patients with Lynch syndrome under the age of 50 years
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          Title: Risk of mCRC in patients with family history under the age of 50 years
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         Item: 
          Title: Risk of mCRC in patients with MSI under the age of 50 years
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         Item: 
          Title: Quality of studies
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        Title: Discussion
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        Title: Funding
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        Title: Acknowledgements
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        Title: Disclosure
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       Item: 
        Title: Supplementary material
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       Item: 
        Title: Data availability
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       Item: 
        Title: Author contributions
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        Title: References
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    Title: Risk of metachronous neoplasia in early-onset colorectal cancer: meta-analysis
    Author: Gianluca Pellino
    Subject: DOI: 10.1093/bjsopen/zrae092; BJS Open, 8, 5, 2024-09-04.; Abstract:  Background: Metachronous colorectal cancer refers to patients developing a second colorectal neoplasia diagnosed at least 6 months after the initial cancer diagnosis, excluding recurrence. The aim of this systematic review is to assess the incidence of metachronous colorectal cancer in early-onset colorectal cancer (defined as age at diagnosis of less than 50 years) and to identify risk factors. Methods: This is a systematic review and meta-analysis performed following the PRISMA statement and registered on PROSPERO. The literature search was conducted in PubMed and Embase. Only studies involving patients with early-onset colorectal cancer (less than 50 years old) providing data on metachronous colorectal cancer were included in the analysis. The primary endpoint was the risk of metachronous colorectal cancer in patients with early-onset colorectal cancer. Secondary endpoints were association with Lynch syndrome, family history and microsatellite instability. Results: Sixteen studies met the inclusion criteria. The incidence of metachronous colorectal cancer was 2.6% (95% c.i. 2.287 3.007). The risk of developing metachronous colorectal cancer in early-onset colorectal cancer versus non-early-onset colorectal cancer patients demonstrated an OR of 0.93 (95% c.i. 0.760 1.141). The incidence of metachronous colorectal cancer in patients with Lynch syndrome was 18.43% (95% c.i. 15.396 21.780), and in patients with family history 10.52% (95% c.i. 5.555 17.659). The proportion of metachronous colorectal cancer tumours in the microsatellite instability population was 19.7% (95% c.i. 13.583 27.2422). Conclusion: The risk of metachronous colorectal cancer in patients with early-onset colorectal cancer is comparable to those with advanced age, but it is higher in patients with Lynch syndrome, family history and microsatellite instability. This meta-analysis demonstrates the need to personalize the manageme
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  Checksum: 3ef1ba53
   Type: CRC32
  Checksum: cb8a72e2a7ec66f19af838dcff514602
   Type: MD5
  Checksum: 58e987aec5826d860be9f15460103267b709b5cd
   Type: SHA-1
  Checksum: f1ba4edb080f56cb46141571a8a4eae167f991b840666491d01832afb6c335fb
   Type: SHA-256