d514eec714ecfef72abbebbe7310a072 319541.pdf da871299533798b3b271ed60627c65ef9f494473 319541.pdf 2f4a7e333a2795ae67c1cafa34ee863d97d99e9276b4e620df799319486276aa 319541.pdf Title: Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model Subject: Research Article Keywords: inhalation, lung, nanocarriers, poly(lactic-co-glycolic acid), vibrating mesh nebulizer Author: Anna Solé-Porta, Aina Areny-Balagueró, Marta Camprubí-Rimblas, Elena Fernández Fernández, Andrew O'Sullivan, Rossella Giannoccari, Ronan MacLoughlin, Daniel Closa, Antonio Artigas, Anna Roig Creator: Arbortext Advanced Print Publisher 9.1.405/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp™ 5.5.13 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Thu Aug 22 10:33:15 2024 CEST ModDate: Thu Sep 5 22:55:47 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 782.589 pts Page rot: 0 File size: 4575014 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FLEJEB+AdvOTe166e003.B Type 1C WinAnsi yes yes no 205 0 FLEJEC+AdvOTe166e003.B+fb Type 1C Custom yes yes yes 206 0 FLEJED+AdvOT4cf4c306.I Type 1C WinAnsi yes yes no 207 0 FLEJEE+AdvOT4cf4c306.I+20 Type 1C WinAnsi yes yes no 208 0 FLEJEF+AdvOTae869a4c Type 1C WinAnsi yes yes no 209 0 FLEJEG+AdvOTae869a4c+fb Type 1C Custom yes yes yes 210 0 FLEJEH+AdvOTe166e003.B+20 Type 1C WinAnsi yes yes no 226 0 FLEJEI+AdvOT52f2e314 Type 1C WinAnsi yes yes no 227 0 FLEJFI+AdvOT52f2e314+20 Type 1C WinAnsi yes yes no 230 0 FLEJGJ+AdvOT52f2e314+fb Type 1C Custom yes yes yes 233 0 FLEJGK+AdvOT88c910f4.B Type 1C WinAnsi yes yes no 239 0 FLEJMJ+AdvOTae869a4c+20 Type 1C WinAnsi yes yes no 143 0 FLEJMK+AdvOT8608a8d1+20 Type 1C WinAnsi yes yes no 142 0 FLEJML+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 140 0 FLEKCJ+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 145 0 FLEKCK+AdvP4C4E74 Type 1C Custom yes yes yes 151 0 FLEKCL+AdvOT0d8bc80f.B Type 1C WinAnsi yes yes no 149 0 FLEKDM+AdvOTac2dc932 Type 1C WinAnsi yes yes no 155 0 FLEKNJ+AdvP4C4E59 Type 1C WinAnsi yes yes no 159 0 FLEKNK+AdvOT9b075a28 Type 1C WinAnsi yes yes no 153 0 FLFEGB+AdvOT9b075a28+22 Type 1C Custom yes yes yes 166 0 FLFJBF+AdvOTdd3b7348.I+03 Type 1C Custom yes yes yes 167 0 FLFJGE+AdvOT52f2e314+02 Type 1C Custom yes yes no 168 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-03 03:58:18 CEST RepresentationInformation: 319541.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-02 11:00:04 CEST Size: 4575014 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 275 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model Destination: temp:book:TitleC_1 Children: Item: Title: 1. Introduction Destination: temp:book:Section1_2 Item: Title: 2. Results and Discussion Destination: temp:book:Section1_3 Children: Item: Title: 2.1. Aerosol Characterization Destination: temp:book:Section2_4 Item: Title: 2.2. Hydrodynamic Diameter and Concentration of the NCs Destination: temp:book:Section2_5 Item: Title: 2.3. NC Morphology Destination: temp:book:Section2_6 Item: Title: 2.4. Lung Biodistribution of NCs In Vivo Destination: temp:book:Section2_7 Item: Title: 2.5. Cellular Uptake of the NCs In Vivo Destination: temp:book:Section2_8 Item: Title: 3. Conclusion Destination: temp:book:Section1_9 Item: Title: 4. Experimental Section Destination: temp:book:Section1_10 Info: Title: Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model Author: Anna Solé-Porta, Aina Areny-Balagueró, Marta Camprubí-Rimblas, Elena Fernández Fernández, Andrew O'Sullivan, Rossella Giannoccari, Ronan MacLoughlin, Daniel Closa, Antonio Artigas, Anna Roig Subject: Research Article Keywords: inhalation, lung, nanocarriers, poly(lactic-co-glycolic acid), vibrating mesh nebulizer Creator: Arbortext Advanced Print Publisher 9.1.405/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp™ 5.5.13 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Thu Aug 22 06:33:15 CEST 2024 ModDate: Thu Sep 05 23:25:47 CEST 2024 ID: 0xff82d2a8c1e63d419f772965aa731d05, 0xb7a16d4540fcba4c8931ffd18f91fcdd Filters: FilterPipeline: FlateDecode FilterPipeline: CCITTFaxDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1787 ImageHeight: 451 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1670 ImageHeight: 413 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1794 ImageHeight: 508 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1644 ImageHeight: 1220 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1671 ImageHeight: 1498 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1421 ImageHeight: 857 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1623 ImageHeight: 1197 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 159 ImageHeight: 136 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 809 ImageHeight: 186 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Fonts: Type1: Font: BaseFont: FLEJEH+AdvOTe166e003.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FLEJEH+AdvOTe166e003.B+20 Flags: Nonsymbolic FontBBox: 0, -239, 1197, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJEI+AdvOT52f2e314 FontSubset: true FirstChar: 37 LastChar: 253 FontDescriptor: FontName: FLEJEI+AdvOT52f2e314 Flags: Nonsymbolic FontBBox: -20, -250, 1104, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJFI+AdvOT52f2e314+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: FLEJFI+AdvOT52f2e314+20 Flags: Nonsymbolic FontBBox: 0, -239, 1197, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLFEGB+AdvOT9b075a28+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FLFEGB+AdvOT9b075a28+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLFJBF+AdvOTdd3b7348.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FLFJBF+AdvOTdd3b7348.I+03 Flags: Symbolic FontBBox: -104, -208, 864, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLFJGE+AdvOT52f2e314+02 FontSubset: true FirstChar: 24 LastChar: 152 FontDescriptor: FontName: FLFJGE+AdvOT52f2e314+02 Flags: Nonsymbolic FontBBox: 9, -229, 1104, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FLEJGJ+AdvOT52f2e314+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FLEJGJ+AdvOT52f2e314+fb Flags: Symbolic FontBBox: 9, -145, 1104, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEJML+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FLEJML+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEJEB+AdvOTe166e003.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: FLEJEB+AdvOTe166e003.B Flags: Nonsymbolic FontBBox: -20, -260, 1104, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJEC+AdvOTe166e003.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FLEJEC+AdvOTe166e003.B+fb Flags: Symbolic FontBBox: 0, -145, 1104, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEJMK+AdvOT8608a8d1+20 FontSubset: true FirstChar: 151 LastChar: 151 FontDescriptor: FontName: FLEJMK+AdvOT8608a8d1+20 Flags: Nonsymbolic FontBBox: 0, 200, 1000, 250 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJGK+AdvOT88c910f4.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: FLEJGK+AdvOT88c910f4.B Flags: Nonsymbolic FontBBox: -20, -250, 1177, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJED+AdvOT4cf4c306.I FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: FLEJED+AdvOT4cf4c306.I Flags: Nonsymbolic FontBBox: -187, -250, 916, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJMJ+AdvOTae869a4c+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: FLEJMJ+AdvOTae869a4c+20 Flags: Nonsymbolic FontBBox: 0, -239, 1197, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJEE+AdvOT4cf4c306.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FLEJEE+AdvOT4cf4c306.I+20 Flags: Nonsymbolic FontBBox: 0, -239, 1197, 687 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEJEF+AdvOTae869a4c FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: FLEJEF+AdvOTae869a4c Flags: Serif, Nonsymbolic FontBBox: -20, -250, 1104, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEKCJ+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FLEKCJ+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: 0, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEJEG+AdvOTae869a4c+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FLEJEG+AdvOTae869a4c+fb Flags: Symbolic FontBBox: 9, -145, 1104, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEKCL+AdvOT0d8bc80f.B FontSubset: true FirstChar: 49 LastChar: 117 FontDescriptor: FontName: FLEKCL+AdvOT0d8bc80f.B Flags: Nonsymbolic FontBBox: -20, -250, 1104, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEKCK+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 254 FontDescriptor: FontName: FLEKCK+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FLEKNK+AdvOT9b075a28 FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: FLEKNK+AdvOT9b075a28 Flags: Nonsymbolic FontBBox: -52, -250, 1000, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEKDM+AdvOTac2dc932 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: FLEKDM+AdvOTac2dc932 Flags: Nonsymbolic FontBBox: -166, -250, 1104, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FLEKNJ+AdvP4C4E59 FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: FLEKNJ+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp™ 5.5.13 ©2000-2018 iText Group NV (AGPL-version) inhalation, lung, nanocarriers, poly(lactic-co-glycolic acid), vibrating mesh nebulizer PStill version 1.78.16 10.1002/smsc.202400066 10.1002/(ISSN)2688-4046 3 Arbortext Advanced Print Publisher 9.1.405/W Unicode 2024-09-06T02:25:47+05:30 2024-09-06T02:25:47+05:30 2024-08-22T04:33:15-04:00 uuid:0b145e6d-d45d-4468-95c2-481de4cb4542 uuid:5efe9263-474a-4eaf-92de-4a42f42820c1 10.1002/smsc.202400066 application/pdf Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model Efficient Nebulization and Pulmonary Biodistribution of Polymeric Nanocarriers in an Acute Lung Injury Preclinical Model Research Article Anna Solé-Porta, Aina Areny-Balagueró, Marta Camprubí-Rimblas, Elena Fernández Fernández, Andrew O'Sullivan, Rossella Giannoccari, Ronan MacLoughlin, Daniel Closa, Antonio Artigas, Anna Roig Aina Areny‐Balagueró Marta Camprubí‐Rimblas Elena Fernández Fernández Andrew O’Sullivan Rossella Giannoccari Ronan MacLoughlin Daniel Closa Antonio Artigas Anna Roig inhalation lung nanocarriers poly(lactic‐co‐glycolic acid) vibrating mesh nebulizer VoR Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 76, 206, 126, 214 Annotation: Subtype: Link Rect: 133, 122, 269, 130 Annotation: Subtype: Link Rect: 265, 98, 292, 106 Annotation: Subtype: Link Rect: 51, 89, 126, 97 Annotation: Subtype: Link Rect: 443, 730, 546, 738 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 48, 730, 154, 738 Annotation: Subtype: Link Rect: 440, 730, 544, 738 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 51, 730, 157, 738 Annotation: Subtype: Link Rect: 443, 730, 546, 738 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 48, 730, 154, 738 Annotation: Subtype: Link Rect: 440, 730, 544, 738 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 51, 730, 157, 738 Annotation: Subtype: Link Rect: 443, 730, 546, 738 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 48, 730, 154, 738 Annotation: Subtype: Link Rect: 440, 730, 544, 738 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 51, 730, 157, 738 Annotation: Subtype: Link Rect: 443, 730, 546, 738 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 48, 730, 154, 738 Annotation: Subtype: Link Rect: 440, 730, 544, 738 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 51, 730, 157, 738 Annotation: Subtype: Link Rect: 443, 730, 546, 738 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 48, 730, 154, 738 Annotation: Subtype: Link Rect: 440, 730, 544, 738 Thumb: true Checksum: fc28f084 Type: CRC32 Checksum: d514eec714ecfef72abbebbe7310a072 Type: MD5 Checksum: da871299533798b3b271ed60627c65ef9f494473 Type: SHA-1 Checksum: 2f4a7e333a2795ae67c1cafa34ee863d97d99e9276b4e620df799319486276aa Type: SHA-256