a9d56c60f1dc972eb6ad212ab378959c ENE-31-e16251.pdf 5fd5731c9d9c1e2264a43703efd81772e94139c7 ENE-31-e16251.pdf e4e8097a1b953d93b1f51fb5d5a56bb16a7b125fe47b5fb5380a65a09a5025c2 ENE-31-e16251.pdf Title: HEADACHES AND FACIAL PAIN ATTRIBUTED TO SARS‐COV‐2 INFECTION AND VACCINATION. A SYSTEMATIC REVIEW. Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Apr 29 12:53:03 2024 CEST ModDate: Mon Apr 29 12:53:04 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 805123 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZKBJUK+Lato-Regular CID TrueType Identity-H yes yes yes 570 0 KLOXSO+Lato-Bold CID TrueType Identity-H yes yes yes 571 0 ZKBJUK+Lato-Italic TrueType WinAnsi yes yes yes 572 0 KLOXSO+Lato-Regular TrueType WinAnsi yes yes yes 573 0 UNMACU+Lato-Bold TrueType WinAnsi yes yes yes 574 0 UNMACU+STIX-Regular Type 1C Custom yes yes yes 358 0 KLOXSO+Lato-Regular TrueType WinAnsi yes yes yes 365 0 YKLULM+Lato-Regular-SC700 TrueType WinAnsi yes yes yes 366 0 UCHMCU+Lato-Regular CID TrueType Identity-H yes yes yes 367 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-25 04:12:18 CET RepresentationInformation: ENE-31-e16251.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-24 16:54:43 CET Size: 805123 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 597 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Headaches and facial pain attributed to SARS-­CoV-­2 infection and vaccination: a systematic review Children: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: METHODS Children: Item: Title: Clinically relevant questions that should be addressed Item: Title: Systematic literature search Item: Title: Data interpretation and evidence-­based answering Item: Title: RESULTS Children: Item: Title: Q1. Is headache and/or facial pain a common symptom of COVID-­19 and/or after acute COVID-­19? Children: Item: Title: Comment Item: Title: Conclusion Item: Title: Q2. What are the clinical characteristics of headache and/or facial pain attributed to acute COVID-­19 and/or after COVID-­19? Children: Item: Title: Comment Item: Title: Conclusion Item: Title: Q3. How is headache and/or facial pain triggered during COVID-­19 and/or after acute COVID-­19? Children: Item: Title: Direct viral entry through olfactory mucosa Item: Title: Inflammatory and cytokine storm, endothelial cell damage and altered state of BBB function Item: Title: Increased CSF pressure because of cerebral venous thrombosis Item: Title: Headache in the phase after the resolution of acute COVID-­19 Item: Title: Conclusion Item: Title: Q4. Is SARS-­CoV-­2 vaccination associated with headache/facial pain, and is there a distinction between different types of vaccines? Children: Item: Title: Comment Item: Title: Conclusion Item: Title: Q5. What are the clinical characteristics of headache and/or facial pain attributed to SARS-­CoV-­2 vaccination? Children: Item: Title: Conclusion Item: Title: Q6. How is headache and/or facial pain triggered by different SARS-­CoV-­2 vaccines? Children: Item: Title: Conclusion Item: Title: CONCLUSIONS AND PROPOSAL FOR DIAGNOSTIC CRITERIA Item: Title: Acute headache attributed to systemic SARS-­CoV-­2 infection Children: Item: Title: Notes Children: Item: Title: Comments Item: Title: Chronic headache attributed to systemic SARS-­CoV-­2 infection Children: Item: Title: Notes Item: Title: Comments Item: Title: CONFLICT OF INTEREST STATEMENT Children: Item: Title: DATA AVAILABILITY STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: REFERENCES Info: Title: HEADACHES AND FACIAL PAIN ATTRIBUTED TO SARS‐COV‐2 INFECTION AND VACCINATION. A SYSTEMATIC REVIEW. 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A SYSTEMATIC REVIEW. 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