01fb67224d25b2df1372ddb00755f682  12883_2024_Article_3600.pdf
c4c55e588b6a435cc9632ef8dcdf38246cbaa7d5  12883_2024_Article_3600.pdf
45cf72a6fa7c22e47e924da1b6493d56fcbe4a39ca6432c0784fe45302a5949a  12883_2024_Article_3600.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Mon Apr  1 14:36:04 2024 CEST
ModDate:         Tue Apr  2 07:20:01 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           14
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       3424316 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     99  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     48  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     51  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     50  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes   1746  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes   1798  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     49  0
SymbolStd                            Type 1C           Custom           yes no  yes     52  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     55  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     58  0
WarnockPro-Semibold                  Type 1C           WinAnsi          yes no  yes     69  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     70  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes     71  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    266  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    267  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes     85  0
QFKGBH+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     98  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes    111  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-11-26 04:30:01 CET
 RepresentationInformation: 12883_2024_Article_3600.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-11-25 18:43:31 CET
  Size: 3424316
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1866
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Migraine treatment: quo vadis? Real-world data study (2015–2022) in Spain
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Database
         Item: 
          Title: Study definitions
          Children: 
           Item: 
            Title: Migraine cases
           Item: 
            Title: Headache cases
           Item: 
            Title: Relevant comorbidities
           Item: 
            Title: Migraine treatments
           Item: 
            Title: Lines of treatment
       Item: 
        Title: Selected patient cohorts
       Item: 
        Title: Statistical analysis
       Item: 
        Title: Ethical considerations
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Demographic and clinical characteristics of the studied population
         Item: 
          Title: Pharmacologic treatment
          Children: 
           Item: 
            Title: Overview of therapies used over the last two years
           Item: 
            Title: Choice of initial therapy and progression to preventive treatments
           Item: 
            Title: Use of anti-CGRP mAbs
       Item: 
        Title: Disease management
        Children: 
         Item: 
          Title: Role of GP per patient treatment cohort
         Item: 
          Title: Role of GP per number of preventive treatments
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Need for improved diagnosis and accurate coding of migraine diagnoses in the healthcare systems
         Item: 
          Title: Need for improved coordination of care and appropriate referral patterns to neurologists
         Item: 
          Title: Need to address specific needs of patients with associated comorbidities to mitigate risk of progression
         Item: 
          Title: Need to optimize treatment and accelerate access to preventive treatment
         Item: 
          Title: Need to address potential barriers in access to innovative treatments
         Item: 
          Title: Limitations
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Mon Apr 01 14:36:04 CEST 2024
    ModDate: Tue Apr 02 07:20:01 CEST 2024
   ID: 0x60621e77064d21891d00017ac6ec5c0e, 0x9d0dc2ea214ea2bc61055ff6820c2e42
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1646
      ImageHeight: 1341
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1607
      ImageHeight: 1354
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1348
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2008
      ImageHeight: 750
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2008
      ImageHeight: 1004
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2008
      ImageHeight: 889
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1881
      ImageHeight: 1071
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -153, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SymbolStd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SymbolStd
       Flags: Nonsymbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Semibold
       Flags: Serif, Nonsymbolic
       FontBBox: -181, -580, 1573, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -176, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -175, -250, 1007, 933
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: QFKGBH+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: QFKGBH+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author_1_="http://springernature.com/ns/xmpExtensions/2.0/authorInfo" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:57d5815f-d28e-4041-80e4-66edeb8edfa0</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:52bc9838-8717-6140-a88c-e91ca49c1c63</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:0f8914bb-f34b-b445-bb50-26367dca48e5</stRef:instanceID>
            <stRef:documentID>xmp.did:f1c18e92-a65d-1441-9e99-540967a08a8e</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 18.3 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2024-04-01T14:36:04+02:00</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:e8145499-04b3-4b86-a219-7b14e61a8392</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-04-01T14:45:15+02:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2024-04-01T14:36:04+02:00</xmp:CreateDate>
         <xmp:ModifyDate>2024-04-02T07:20:01+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-04-02T07:20:01+02:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 18.3 (Windows)</xmp:CreatorTool>
         <prism:aggregationType>journal</prism:aggregationType>
         <crossmark:DOI>10.1186/s12883-024-03600-8</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12883-024-03600-8</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author_1_:name>Patricia Pozo-Rosich</author_1_:name>
                  <author_1_:orcid>https://orcid.org/0000-0003-0796-4702</author_1_:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>An unordered array of references to resources that were incorporated, by inclusion or reference, into this document.</pdfaProperty:description>
                           <pdfaProperty:name>Ingredients</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 415, 81, 527, 73
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 317, 73, 449, 65
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 148, 601, 161, 588
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 152, 683, 157, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 143, 659, 148, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 95, 599, 100, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 106, 599, 110, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 159, 563, 164, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 170, 563, 180, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 149, 503, 154, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 160, 503, 165, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 171, 503, 180, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 186, 503, 196, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 137, 467, 147, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 186, 431, 196, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 202, 431, 212, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 283, 395, 288, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 56, 383, 66, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 72, 383, 82, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 241, 347, 251, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 192, 263, 202, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 208, 263, 218, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 121, 239, 131, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 156, 191, 166, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 242, 143, 252, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 259, 143, 269, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 275, 143, 285, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 186, 107, 196, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 523, 707, 533, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 491, 671, 501, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 505, 671, 515, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 526, 635, 536, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 304, 623, 314, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 516, 611, 521, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 526, 611, 536, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 304, 599, 314, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 344, 563, 354, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 462, 539, 472, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 477, 539, 487, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 211, 215, 221, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 227, 215, 236, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 490, 647, 500, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 99, 407, 109, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 409, 611, 414, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 339, 575, 344, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 480, 443, 485, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 437, 371, 442, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 528, 263, 533, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 459, 107, 464, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 299, 133, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 162, 191, 167, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 231, 71, 236, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 119
      Annotation: 
       Subtype: Link
       Rect: 334, 335, 339, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 119
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 83, 118, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 127
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 201, 287, 206, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 213, 287, 222, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 92, 227, 102, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 107, 227, 117, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 215, 167, 225, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 232, 167, 241, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 203, 107, 208, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 212, 107, 222, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 227, 107, 237, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 201, 83, 210, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 215, 83, 225, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 229, 83, 239, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 390, 347, 395, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 401, 347, 411, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 331, 263, 341, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 395, 227, 405, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 409, 227, 419, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 424, 227, 434, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 516, 167, 521, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 526, 167, 536, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 304, 155, 314, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 349, 83, 358, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 364, 83, 374, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 379, 83, 389, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 156, 647, 166, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 171, 647, 181, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 94, 611, 104, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 237, 551, 247, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 251, 551, 261, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 267, 551, 277, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 101, 467, 111, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 141, 431, 146, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 151, 431, 161, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 166, 431, 176, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 181, 431, 191, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 196, 431, 206, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 80, 371, 85, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 187, 335, 197, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 201, 335, 211, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 216, 335, 226, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 152, 275, 162, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 143, 227, 152, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 157, 227, 167, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 98, 179, 108, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 112, 179, 122, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 127, 179, 137, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 59, 107, 69, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 512, 707, 517, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 526, 707, 536, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 304, 695, 314, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 320, 695, 330, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 431, 407, 441, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 489, 359, 499, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 504, 359, 514, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 518, 359, 528, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 307, 263, 317, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 485, 179, 495, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 275, 224, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 496, 491, 529, 482
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 482, 404, 473
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 347, 234, 535, 225
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 225, 400, 216
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
  Checksum: 4f85fbb6
   Type: CRC32
  Checksum: 01fb67224d25b2df1372ddb00755f682
   Type: MD5
  Checksum: c4c55e588b6a435cc9632ef8dcdf38246cbaa7d5
   Type: SHA-1
  Checksum: 45cf72a6fa7c22e47e924da1b6493d56fcbe4a39ca6432c0784fe45302a5949a
   Type: SHA-256