7368a37a9dcfa47a1b7a52f0fb4e7924 10194_2024_Article_1747.pdf 9cdfc6603d6c56de2038b5f80d12c7e37941314b 10194_2024_Article_1747.pdf 1840da05698b4d11ff6e554f4ab37cb03f6037f4ac08c59ebf16163cd2bdd0f0 10194_2024_Article_1747.pdf Title: Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in Spain? Results of a cost-effectiveness analysis Subject: The Journal of Headache and Pain, https://doi.org/10.1186/s10194-024-01747-w Keywords: Chronic migraine;Episodic migraine;Topiramate;Erenumab;Cost-effectiveness;Spain Author: Patricia Pozo-Rosich Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Mar 15 12:42:48 2024 CET ModDate: Fri Mar 15 13:49:13 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 902627 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 66 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 67 0 MyriadPro-It Type 1C Custom yes no yes 68 0 YIJQGS+OpenSans Type 1C WinAnsi yes yes no 507 0 MyriadPro-Light Type 1C Custom yes no yes 99 0 MyriadPro-Semibold Type 1C Custom yes no yes 98 0 SFMALE+STIX-Regular Type 1C Custom yes yes yes 69 0 WarnockPro-Regular Type 1C Custom yes no yes 70 0 PGBIVK+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 97 0 MyriadPro-Regular2 Type 1C WinAnsi yes no yes 470 0 IYKSBY+STIXMath-Regular Type 1C WinAnsi yes yes yes 449 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-28 04:35:40 CET RepresentationInformation: 10194_2024_Article_1747.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-27 15:53:34 CET Size: 902627 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 580 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in Spain? Results of a cost-effectiveness analysis Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Results Item: Title: Conclusions Item: Title: Background Item: Title: Methods Children: Item: Title: Model structure Item: Title: Probabilities Item: Title: Utilities Item: Title: Resource use and costs Item: Title: Sensitivity analysis Item: Title: Results Children: Item: Title: Episodic migraine Item: Title: Chronic migraine Item: Title: Discussion Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in Spain? Results of a cost-effectiveness analysis Author: Patricia Pozo-Rosich Subject: The Journal of Headache and Pain, https://doi.org/10.1186/s10194-024-01747-w Keywords: Chronic migraine;Episodic migraine;Topiramate;Erenumab;Cost-effectiveness;Spain Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Mar 15 12:42:48 CET 2024 ModDate: Fri Mar 15 13:49:13 CET 2024 ID: 0xda8af7de4088dd59803daae4c7be82a7, 0x933d1ee848dff29329a737a3a49260f9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 115 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1378 ImageHeight: 685 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1418 ImageHeight: 854 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: IYKSBY+STIXMath-Regular FontSubset: true FirstChar: 32 LastChar: 174 FontDescriptor: FontName: IYKSBY+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SFMALE+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 62 FontDescriptor: FontName: SFMALE+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YIJQGS+OpenSans FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: YIJQGS+OpenSans Flags: Nonsymbolic FontBBox: -550, -271, 1204, 1048 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: PGBIVK+TimesNewRomanPSMT FontSubset: true FirstChar: 128 LastChar: 128 FontDescriptor: FontName: PGBIVK+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2024-03-15T11:42:48 Adobe InDesign 15.1 (Windows) 2024-03-15T13:49:13+01:00 2024-03-15T13:49:13+01:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Chronic migraine;Episodic migraine;Topiramate;Erenumab;Cost-effectiveness;Spain False application/pdf https://doi.org/10.1186/s10194-024-01747-w Springer Milan The Journal of Headache and Pain, https://doi.org/10.1186/s10194-024-01747-w Chronic migraine Episodic migraine Topiramate Erenumab Cost-effectiveness Spain Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in Spain? Results of a cost-effectiveness analysis Patricia Pozo-Rosich José Luis Poveda Carlos Crespo María Martínez José Manuel Rodríguez Pablo Irimia 10.1186/s10194-024-01747-w 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s10194-024-01747-w 10.1186/s10194-024-01747-w 1129-2377 journal The Journal of Headache and Pain The Author(s) 2010-04-23 true 10.1186/s10194-024-01747-w noindex springer.com springerlink.com uuid:dcffe9c1-ff81-4d3f-b9cf-990a21346eb7 uuid:be6a88f5-392d-4f1f-a9fd-99342632a4eb default 1 converted uuid:dcffe9c1-ff81-4d3f-b9cf-990a21346eb7 converted to PDF/A-2b pdfToolbox 2024-03-15T11:45:18Z 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 538, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 270, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 175, 607, 180, 595 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 156, 571, 161, 559 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 166, 571, 171, 559 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 227, 547, 232, 535 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 173, 523, 178, 511 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 59, 499, 64, 487 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 70, 499, 75, 487 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 76, 475, 81, 463 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 87, 475, 92, 463 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 96, 415, 101, 403 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 105, 415, 110, 403 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 116, 415, 126, 403 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 201, 367, 211, 355 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 135, 283, 145, 271 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 150, 283, 160, 271 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 92, 259, 102, 247 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 95, 199, 105, 187 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 111, 199, 120, 187 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 169, 115, 179, 103 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 185, 115, 195, 103 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 205, 103, 215, 91 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 154, 91, 164, 79 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 407, 692, 417, 680 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 423, 692, 432, 680 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 428, 680, 438, 668 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 399, 644, 409, 632 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 414, 644, 423, 632 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 445, 596, 454, 584 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 458, 560, 468, 548 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 473, 560, 483, 548 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 329, 404, 339, 392 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 345, 404, 354, 392 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 430, 248, 440, 236 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 334, 236, 344, 224 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 350, 236, 360, 224 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 431, 236, 441, 224 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 477, 164, 487, 152 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 382, 152, 392, 140 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 398, 152, 408, 140 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 481, 152, 491, 140 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 379, 92, 389, 80 Flags: Print AppearanceDictionary: true Destination: 226 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 275, 466, 285, 454 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 191, 454, 201, 442 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 207, 454, 217, 442 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 198, 287, 208, 274 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 159, 238, 169, 226 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 213, 226, 223, 214 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 221, 142, 226, 130 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 397, 298, 407, 286 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 404, 250, 409, 238 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 412, 226, 421, 214 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 329, 202, 339, 190 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 487, 190, 496, 178 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 427, 178, 437, 166 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 410, 94, 419, 82 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 424, 94, 434, 82 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 439, 94, 449, 82 Flags: Print AppearanceDictionary: true Destination: 321 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 145, 542, 155, 530 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 230, 530, 239, 518 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 244, 530, 254, 518 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 259, 530, 269, 518 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 154, 518, 164, 506 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 256, 506, 266, 494 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 187, 410, 197, 398 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 59, 374, 70, 362 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 156, 362, 166, 350 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 210, 266, 219, 254 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 225, 266, 234, 254 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 144, 98, 154, 86 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 162, 98, 172, 86 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 179, 98, 189, 86 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 335, 597, 345, 584 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 504, 549, 514, 536 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 343, 489, 353, 476 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 334, 369, 339, 356 Flags: Print AppearanceDictionary: true Destination: 144 Annotation: Subtype: Link Rect: 435, 357, 445, 344 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 451, 357, 461, 344 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 388, 273, 398, 260 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 486, 249, 496, 236 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 367, 165, 377, 152 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 364, 105, 374, 92 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 403, 82, 412, 68 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 261, 640, 269, 631 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 273, 640, 281, 631 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 280, 628, 287, 619 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 261, 604, 269, 595 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 261, 592, 269, 583 Flags: Print AppearanceDictionary: true Destination: 321 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 264, 705, 274, 692 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 167, 681, 177, 668 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 59, 606, 69, 594 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 140, 570, 150, 558 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 59, 450, 69, 438 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 173, 390, 183, 378 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 107, 244, 111, 232 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 399, 373, 404, 361 Flags: Print AppearanceDictionary: true Destination: 189 Annotation: Subtype: Link Rect: 502, 338, 507, 325 Flags: Print AppearanceDictionary: true Destination: 167 Annotation: Subtype: Link Rect: 481, 289, 486, 277 Flags: Print AppearanceDictionary: true Destination: 189 Annotation: Subtype: Link Rect: 480, 172, 485, 160 Flags: Print AppearanceDictionary: true Destination: 148 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 236, 298, 241, 286 Flags: Print AppearanceDictionary: true Destination: 189 Annotation: Subtype: Link Rect: 172, 238, 177, 226 Flags: Print AppearanceDictionary: true Destination: 189 Annotation: Subtype: Link Rect: 135, 142, 145, 130 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 172, 142, 177, 130 Flags: Print AppearanceDictionary: true Destination: 167 Annotation: Subtype: Link Rect: 167, 82, 172, 70 Flags: Print AppearanceDictionary: true Destination: 189 Annotation: Subtype: Link Rect: 434, 358, 439, 346 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 445, 358, 455, 346 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 443, 334, 453, 322 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 461, 334, 470, 322 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 478, 334, 488, 322 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 436, 214, 446, 202 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 452, 214, 462, 202 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 481, 130, 491, 118 Flags: Print AppearanceDictionary: true Destination: 226 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 277, 705, 287, 692 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 184, 597, 194, 584 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 275, 525, 285, 512 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 171, 489, 181, 476 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 186, 489, 196, 476 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 238, 441, 248, 428 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 161, 393, 171, 380 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 178, 393, 188, 380 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 104, 369, 114, 356 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 275, 357, 285, 344 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 245, 309, 255, 296 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 106, 261, 116, 248 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 210, 225, 220, 212 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 225, 225, 235, 212 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 213, 177, 223, 164 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 109, 165, 118, 152 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 80, 153, 90, 140 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 121, 117, 131, 104 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 159, 105, 169, 92 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 523, 693, 533, 680 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 402, 585, 412, 572 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 438, 525, 448, 512 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 453, 525, 463, 512 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 411, 489, 421, 476 Flags: Print AppearanceDictionary: true Destination: 387 Annotation: Subtype: Link Rect: 308, 319, 318, 307 Flags: Print AppearanceDictionary: true Destination: 321 Annotation: Subtype: Link Rect: 395, 283, 405, 271 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 496, 118, 529, 110 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 109, 405, 101 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 264, 264, 286, 256 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 255, 195, 247 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 190, 237, 275, 229 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 228, 107, 220 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 101, 192, 230, 184 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 156, 262, 148 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 129, 204, 121 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 236, 111, 282, 103 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 102, 154, 94 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 75, 241, 67 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 375, 685, 511, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 430, 658, 532, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 631, 465, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 375, 595, 508, 587 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 484, 559, 530, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 550, 393, 542 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 333, 487, 464, 479 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 451, 460, 523, 452 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 451, 380, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 516, 433, 538, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 424, 520, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 397, 527, 389 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 388, 353, 380 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 516, 370, 538, 362 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 361, 527, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 392, 307, 524, 299 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 280, 523, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 272, 532, 261 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 262, 485, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 469, 235, 534, 227 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 227, 510, 216 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 484, 172, 530, 164 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 163, 441, 155 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 100, 527, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 91, 399, 83 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 205, 703, 277, 695 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 694, 132, 686 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 261, 676, 283, 668 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 667, 171, 659 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 142, 622, 284, 614 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 89, 595, 219, 587 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 559, 214, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 532, 203, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 141, 496, 266, 488 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 116, 469, 245, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 415, 200, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 89, 379, 191, 371 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 224, 352, 279, 344 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 343, 151, 335 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 244, 325, 282, 317 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 316, 145, 308 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 212, 253, 285, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 245, 261, 234 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 156, 154, 283, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 145, 128, 137 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 509, 478, 531, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 469, 446, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 332, 190, 455, 182 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 354, 154, 487, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 461, 118, 533, 110 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 109, 380, 101 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 151, 667, 272, 659 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 658, 106, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 586, 166, 578 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 164, 550, 272, 542 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 541, 93, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 207, 514, 279, 506 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 505, 132, 497 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 469, 203, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 424, 274, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 415, 281, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 406, 130, 398 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 123, 388, 270, 380 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 173, 370, 287, 362 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 362, 286, 351 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 353, 289, 342 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 344, 161, 333 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 316, 284, 308 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 307, 123, 299 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 280, 241, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 253, 284, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 244, 158, 236 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 249, 217, 282, 209 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 208, 160, 200 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 172, 196, 164 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 986d7b47 Type: CRC32 Checksum: 7368a37a9dcfa47a1b7a52f0fb4e7924 Type: MD5 Checksum: 9cdfc6603d6c56de2038b5f80d12c7e37941314b Type: SHA-1 Checksum: 1840da05698b4d11ff6e554f4ab37cb03f6037f4ac08c59ebf16163cd2bdd0f0 Type: SHA-256