28e318a1b795c8cd3c15dc28b5c42f46 322309.pdf 20d0ef6cded6a76f196c5f5b544614b2244067de 322309.pdf 20f201c482c8c729010bace89129734dd36d4f518a879543feaeeb393af8443b 322309.pdf Title: Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks Subject: DOI: 10.1093/jac/dkae456; Journal of Antimicrobial Chemotherapy, 80, 3, 2024-12-23.; Abstract: Objectives: To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with the most frequently prescribed first-line treatment regimens, among antiretroviral-naive people with HIV from CoRIS, a multicentre cohort in Spain, in 2018–23. Methods: We used multivariable regression models to compare viral suppression (VS) (HIV RNA viral load <50 copies/mL), change in CD4 cell counts, persistence and treatment discontinuations due to adverse events (AEs), at 96 (±24) weeks after treatment initiation. Results: Of 2359 participants, DTG/3TC was prescribed in 472 (20.0%), bictegravir/tenofovir alafenamide (TAF)/emtricitabine (FTC) in 1134 (48.1%), DTG + tenofovir disoproxil fumarate/FTC in 300 (12.7%), DTG/abacavir/3TC in 273 (11.6%) and darunavir/cobicistat/TAF/FTC in 180 (7.6%). At 96 weeks from treatment initiation, 94.0% of participant Keywords: Author: Inés Suárez-García Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Wed Feb 19 01:56:09 2025 CET ModDate: Fri Jan 16 08:49:17 2026 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 10 Encrypted: no Page size: 612.283 x 790.866 pts Page rot: 0 File size: 485371 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MTJLCM+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 29 0 GMNNQU+FSMe-LightItalic Type 1C Custom yes yes yes 52 0 CTHXQI+FSMe-Light Type 1C Custom yes yes yes 27 0 QXCYPU+FSMe-Bold Type 1C Custom yes yes yes 26 0 VPJBRZ+STIXGeneral-Regular Type 1C Custom yes yes yes 28 0 SQAFSR+ArialMT TrueType WinAnsi yes yes no 1 0 VCOVEY+FSMe-BoldItalic Type 1C Custom yes yes yes 30 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-01-17 04:32:28 CET RepresentationInformation: 322309.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-01-16 10:18:01 CET Size: 485371 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1181 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Introduction Destination: secdkae456-s1 Item: Title: Materials and methods Destination: secdkae456-s2 Children: Item: Title: Study design Destination: secdkae456-s2.1 Item: Title: Study population Destination: secdkae456-s2.2 Item: Title: Outcomes Destination: secdkae456-s2.3 Item: Title: Statistical analysis Destination: secdkae456-s2.4 Item: Title: Ethics approval and informed consent Destination: secdkae456-s2.5 Item: Title: Results Destination: secdkae456-s3 Children: Item: Title: VS, IR and VF Destination: secdkae456-s3.1 Item: Title: Persistence and tolerability Destination: secdkae456-s3.2 Item: Title: Effectiveness and tolerability in specific subgroups Destination: secdkae456-s3.3 Item: Title: Discussion Destination: secdkae456-s4 Children: Item: Title: Conclusions Destination: secdkae456-s4.1 Item: Title: Acknowledgements Destination: acknow Children: Item: Title: Group authorship Destination: secdkae456-s5 Item: Title: Funding Destination: secdkae456-s6 Item: Title: Transparency declarations Destination: secdkae456-s7 Children: Item: Title: Author contributions Destination: secdkae456-s7.1 Item: Title: Supplementary data Destination: secdkae456-s8 Item: Title: References Destination: reflist Info: Title: Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks Author: Inés Suárez-García Subject: DOI: 10.1093/jac/dkae456; Journal of Antimicrobial Chemotherapy, 80, 3, 2024-12-23.; Abstract: Objectives: To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with the most frequently prescribed first-line treatment regimens, among antiretroviral-naive people with HIV from CoRIS, a multicentre cohort in Spain, in 2018–23. Methods: We used multivariable regression models to compare viral suppression (VS) (HIV RNA viral load <50 copies/mL), change in CD4 cell counts, persistence and treatment discontinuations due to adverse events (AEs), at 96 (±24) weeks after treatment initiation. Results: Of 2359 participants, DTG/3TC was prescribed in 472 (20.0%), bictegravir/tenofovir alafenamide (TAF)/emtricitabine (FTC) in 1134 (48.1%), DTG + tenofovir disoproxil fumarate/FTC in 300 (12.7%), DTG/abacavir/3TC in 273 (11.6%) and darunavir/cobicistat/TAF/FTC in 180 (7.6%). At 96 weeks from treatment initiation, 94.0% of participant Keywords: Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Wed Feb 19 02:26:09 CET 2025 ModDate: Fri Jan 16 08:49:17 CET 2026 ID: 0xa5f5a2b6634004aef04761a26631da2b, 0x176b8794f38070db9a336d2d2ef0d842 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 139 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: MTJLCM+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: GMNNQU+FSMe-LightItalic FontSubset: true FirstChar: 1 LastChar: 73 FontDescriptor: FontName: GMNNQU+FSMe-LightItalic Flags: Nonsymbolic, Italic FontBBox: -148, -276, 1184, 1034 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QXCYPU+FSMe-Bold FontSubset: true FirstChar: 1 LastChar: 77 FontDescriptor: FontName: QXCYPU+FSMe-Bold Flags: Nonsymbolic, ForceBold FontBBox: -80, -318, 1312, 1128 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CTHXQI+FSMe-Light FontSubset: true FirstChar: 1 LastChar: 99 FontDescriptor: FontName: CTHXQI+FSMe-Light Flags: Nonsymbolic FontBBox: -82, -276, 1220, 1033 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VPJBRZ+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: VPJBRZ+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VCOVEY+FSMe-BoldItalic FontSubset: true FirstChar: 1 LastChar: 34 FontDescriptor: FontName: VCOVEY+FSMe-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -151, -319, 1274, 1133 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: SQAFSR+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: SQAFSR+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: MTJLCM+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MTJLCM+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true XMP: uuid:06588db2-1463-428c-8ef7-7115213c5d05 uuid:B3245FCC-7F00-DE98-88AD-0BF86B9FA64D True PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0 application/pdf 10.1093/jac/dkae456 en Oxford University Press Long-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks Inés Suárez-García Belén Alejos Cristina Moreno Juan Martín Torres Mar Masiá Lucio J. García-Fraile Melchor Riera David Dalmau Rafael Rodríguez-Rosado Roberto Muga Santiago Moreno Inma Jarrín DOI: 10.1093/jac/dkae456; Journal of Antimicrobial Chemotherapy, 80, 3, 2024-12-23.; Abstract: Objectives: To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with the most frequently prescribed first-line treatment regimens, among antiretroviral-naive people with HIV from CoRIS, a multicentre cohort in Spain, in 2018–23. Methods: We used multivariable regression models to compare viral suppression (VS) (HIV RNA viral load <50 copies/mL), change in CD4 cell counts, persistence and treatment discontinuations due to adverse events (AEs), at 96 (±24) weeks after treatment initiation. Results: Of 2359 participants, DTG/3TC was prescribed in 472 (20.0%), bictegravir/tenofovir alafenamide (TAF)/emtricitabine (FTC) in 1134 (48.1%), DTG + tenofovir disoproxil fumarate/FTC in 300 (12.7%), DTG/abacavir/3TC in 273 (11.6%) and darunavir/cobicistat/TAF/FTC in 180 (7.6%). At 96 weeks from treatment initiation, 94.0% of participant © The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. Journal Journal of Antimicrobial Chemotherapy © The Author(s) 2024. 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