12a69e76d269b009d1ca690e55193234  322317.pdf
46e443dfb7b4df5f6f80b51e2c640b5d722b5111  322317.pdf
0d338250f403ff68d66917b13221822692e1de9239fb236ed499279c79997f4a  322317.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Tue Nov  5 14:54:58 2024 CET
ModDate:         Tue Nov  5 15:59:15 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           6
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       1776576 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     60  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     27  0
MyriadPro-Semibold                   Type 1C           WinAnsi          yes no  yes     62  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes    729  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     29  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    730  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     28  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes    731  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes    793  0
SymbolStd                            Type 1C           Custom           yes no  yes     30  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     33  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     36  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     61  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    150  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    151  0
GKZEER+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     85  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-12-20 04:16:59 CET
 RepresentationInformation: 322317.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-12-19 08:53:55 CET
  Size: 1776576
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 809
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Quality of life and mental health status in caregivers of pediatric patients with nephropathic cystinosis
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Nov 05 14:54:58 CET 2024
    ModDate: Tue Nov 05 15:59:15 CET 2024
   ID: 0x83a13f2c3d9e7f45ef6f5828f820813a, 0x6bed65a5c429b9da349c88144694a979
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1303
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -175, -250, 1007, 933
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -153, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SymbolStd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SymbolStd
       Flags: Nonsymbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: GKZEER+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: GKZEER+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author_1_="http://springernature.com/ns/xmpExtensions/2.0/authorInfo" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:a6d0316a-88c6-4ec8-b7dd-d9292be955df</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:6b93dec5-d5f8-644e-b4fb-11b95048b066</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:79b1f0bb-00a5-bd46-ab4e-3c5f020df36b</stRef:instanceID>
            <stRef:documentID>xmp.did:cc08434a-e941-9a45-a012-8f06ee016e10</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 18.3 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2024-11-05T14:54:58+01:00</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:6e37d990-b180-46be-a6d5-8f97527bf25a</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-11-05T15:16:40+01:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2024-11-05T14:54:58+01:00</xmp:CreateDate>
         <xmp:ModifyDate>2024-11-05T15:59:15+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-11-05T15:59:15+01:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 18.3 (Windows)</xmp:CreatorTool>
         <prism:aggregationType>journal</prism:aggregationType>
         <crossmark:DOI>10.1186/s13023-024-03417-1</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13023-024-03417-1</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author_1_:name>Gema Ariceta</author_1_:name>
                  <author_1_:orcid>http://orcid.org/0000-0003-1763-1098</author_1_:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>An unordered array of references to resources that were incorporated, by inclusion or reference, into this document.</pdfaProperty:description>
                           <pdfaProperty:name>Ingredients</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 415, 81, 527, 73
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 317, 73, 449, 65
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 311, 533, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 417, 251, 422, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 105, 239, 110, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 337, 575, 350, 562
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 695, 64, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 155, 587, 160, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 166, 515, 171, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 162, 419, 167, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 172, 419, 177, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 156, 287, 160, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 166, 287, 171, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 220, 263, 225, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 83, 227, 88, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 242, 227, 247, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 210, 131, 220, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 368, 647, 378, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 493, 323, 503, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 448, 179, 458, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 522, 83, 532, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 551, 261, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 77, 419, 82, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 238, 407, 243, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 362, 683, 367, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 67
      Annotation: 
       Subtype: Link
       Rect: 366, 623, 376, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 380, 623, 390, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 474, 599, 479, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 485, 599, 489, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 435, 479, 445, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 450, 479, 459, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 465, 479, 475, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 307, 371, 317, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 335, 335, 339, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 344, 335, 349, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 307, 311, 317, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 323, 266, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 239, 287, 249, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 190, 203, 199, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 233, 155, 242, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 150, 119, 160, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 253, 71, 262, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 413, 287, 423, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 357, 119, 367, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 434, 95, 444, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 361, 71, 371, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 375, 71, 385, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 390, 71, 400, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 404, 71, 414, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 683, 272, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 278, 683, 288, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 56, 671, 66, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 71, 671, 81, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 59, 623, 69, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 283, 599, 288, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 56, 587, 66, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 71, 587, 81, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 204, 527, 214, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 218, 527, 228, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 168, 101, 264, 92
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 393, 612, 492, 603
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
  Checksum: 213b869d
   Type: CRC32
  Checksum: 12a69e76d269b009d1ca690e55193234
   Type: MD5
  Checksum: 46e443dfb7b4df5f6f80b51e2c640b5d722b5111
   Type: SHA-1
  Checksum: 0d338250f403ff68d66917b13221822692e1de9239fb236ed499279c79997f4a
   Type: SHA-256