a35518230bf0a68a8c0b8b7eb6bced33 322327.pdf 8a7d3304f0673ed819db4576d8f848212c552c0c 322327.pdf 0a3e66ae2e0d99af5e2c6c052d1afc5e34f70bad8610f5c16e6c758063c71a16 322327.pdf Title: Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry Subject: DOI: 10.1093/ndt/gfae034 Nephrology Dialysis Transplantation, 39, 9, 07-02-2024. Abstract: Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death.We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups. We examined age and sex standardized incidence, trend of the incidence and survival.The standardized incidence of KRT for ESKD due to PGD was 16.6 per million population (pmp), ranging from 8.6 pmp in Serbia to 20.0 pmp in France. Immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) had the highest incidences, of 4.6 pmp and 2.6 pmp, respectively. Histologically non-examined PGDs represented over 50% of cases in Serbia, Bosnia and Herzegovina, and Romania and were also common in Greece, Estonia, Belgium and Sweden. The incidence declined from 18.6 pmp in 2000 to 14.5 pmp in 2013, after which it stabilized. All PGD subgroups had 5-year survival probabilities above 50%, with crescentic glomerulonephritis having the highest risk of death [adjusted hazard ratio 1.8 (95% confidence interval 1.6–1.9)] compared with IgAN. Cardiovascular disease was the most common cause of death (33.9%).The incidence of KRT for ESKD due to PGD showed large differences between countries and was highest and increasing for IgAN and FSGS. Lack of kidney biopsy facilities in some countries may have affected accurate assignment of the cause of ESKD. The recognition of the incidence and outcomes of KRT among different PGD subgroups may contribute to a more individualized patient care approach. Keywords: dialysis, epidemiology, kidney replacement therapy, outcome, primary glomerular disease Author: Abd ElHafeez Samar, Kramer Anneke, Arici Mustafa, Arnol Miha, Ã…sberg Anders, Bell Samira, Belliere Julie, Corte Carmen DÃ�az, Fresnedo Gema Fernández, Hemmelder Marc, Heylen Line, Hommel Kristine, Kerschbaum Julia, Naumović Radomir, Nitsch Dorothea, Santamaria Rafael, Finne Patrik, Palsson Runolfur, Pippias Maria, Resic Halima, Rosenberg Mai, de Pablos Carmen Santiuste, Segelmark MÃ¥rten, Sørensen Søren Schwartz, Soler Maria Jose, Vidal Enrico, Jager Kitty J., Ortiz Alberto, Stel Vianda S. 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Subject: DOI: 10.1093/ndt/gfae034 Nephrology Dialysis Transplantation, 39, 9, 07-02-2024. Abstract: Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death.We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups. We examined age and sex standardized incidence, trend of the incidence and survival.The standardized incidence of KRT for ESKD due to PGD was 16.6 per million population (pmp), ranging from 8.6 pmp in Serbia to 20.0 pmp in France. Immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) had the highest incidences, of 4.6 pmp and 2.6 pmp, respectively. Histologically non-examined PGDs represented over 50% of cases in Serbia, Bosnia and Herzegovina, and Romania and were also common in Greece, Estonia, Belgium and Sweden. The incidence declined from 18.6 pmp in 2000 to 14.5 pmp in 2013, after which it stabilized. All PGD subgroups had 5-year survival probabilities above 50%, with crescentic glomerulonephritis having the highest risk of death [adjusted hazard ratio 1.8 (95% confidence interval 1.6–1.9)] compared with IgAN. Cardiovascular disease was the most common cause of death (33.9%).The incidence of KRT for ESKD due to PGD showed large differences between countries and was highest and increasing for IgAN and FSGS. Lack of kidney biopsy facilities in some countries may have affected accurate assignment of the cause of ESKD. The recognition of the incidence and outcomes of KRT among different PGD subgroups may contribute to a more individualized patient care approach. Keywords: dialysis, epidemiology, kidney replacement therapy, outcome, primary glomerular disease Creator: OUP Producer: Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Mon Aug 12 12:56:26 CEST 2024 ModDate: Mon Jan 12 10:13:00 CET 2026 ID: 0xdf9990e9300558674442b9570c009ffc, 0x69b5303f1ff95a4351d968880d597ce8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1404 ImageHeight: 232 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 379 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 379 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG 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Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com All Rights Reserved application/pdf doi:10.1093/ndt/gfae034 © The Author(s) 2024. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Abd ElHafeez Samar Kramer Anneke Arici Mustafa Arnol Miha Åsberg Anders Bell Samira Belliere Julie Corte Carmen Díaz Fresnedo Gema Fernández Hemmelder Marc Heylen Line Hommel Kristine Kerschbaum Julia Naumović Radomir Nitsch Dorothea Santamaria Rafael Finne Patrik Palsson Runolfur Pippias Maria Resic Halima Rosenberg Mai de Pablos Carmen Santiuste Segelmark Mårten Sørensen Søren Schwartz Soler Maria Jose Vidal Enrico Jager Kitty J. Ortiz Alberto Stel Vianda S. Oxford University Press DOI: 10.1093/ndt/gfae034 Nephrology Dialysis Transplantation, 39, 9, 07-02-2024. Abstract: Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death.We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups. We examined age and sex standardized incidence, trend of the incidence and survival.The standardized incidence of KRT for ESKD due to PGD was 16.6 per million population (pmp), ranging from 8.6 pmp in Serbia to 20.0 pmp in France. Immunoglobulin A nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) had the highest incidences, of 4.6 pmp and 2.6 pmp, respectively. Histologically non-examined PGDs represented over 50% of cases in Serbia, Bosnia and Herzegovina, and Romania and were also common in Greece, Estonia, Belgium and Sweden. The incidence declined from 18.6 pmp in 2000 to 14.5 pmp in 2013, after which it stabilized. All PGD subgroups had 5-year survival probabilities above 50%, with crescentic glomerulonephritis having the highest risk of death [adjusted hazard ratio 1.8 (95% confidence interval 1.6–1.9)] compared with IgAN. Cardiovascular disease was the most common cause of death (33.9%).The incidence of KRT for ESKD due to PGD showed large differences between countries and was highest and increasing for IgAN and FSGS. Lack of kidney biopsy facilities in some countries may have affected accurate assignment of the cause of ESKD. The recognition of the incidence and outcomes of KRT among different PGD subgroups may contribute to a more individualized patient care approach. dialysis epidemiology kidney replacement therapy outcome primary glomerular disease Incidence and outcomes of kidney replacement therapy for end-stage kidney disease due to primary glomerular disease in Europe: findings from the ERA Registry Abd ElHafeez Samar, Kramer Anneke, Arici Mustafa, Arnol Miha, Ã…sberg Anders, Bell Samira, Belliere Julie, Corte Carmen Díaz, Fresnedo Gema Fernández, Hemmelder Marc, Heylen Line, Hommel Kristine, Kerschbaum Julia, Naumović Radomir, Nitsch Dorothea, Santamaria Rafael, Finne Patrik, Palsson Runolfur, Pippias Maria, Resic Halima, Rosenberg Mai, de Pablos Carmen Santiuste, Segelmark MÃ¥rten, Sørensen Søren Schwartz, Soler Maria Jose, Vidal Enrico, Jager Kitty J., Ortiz Alberto, Stel Vianda S. uuid:c0accc19-5e2a-37b6-8d04-2c26a49263f2 uuid:0d3e5361-c55e-4583-a336-80363d9b70b5 True Pages: Page: Label: 1449 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