b4defb1e336390c6f5bb8a210dcbd844 322334.pdf d07057c2d892a08efb734572133d456ac3860e69 322334.pdf 9d2e7f0f12d773f87745792a360d531757bad08612627246317b87d5ef1ae68d 322334.pdf Title: Subject: Keywords: The JAMA Network Author: American Medical Association Creator: XPP Producer: ; modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Tue Nov 5 14:47:38 2024 CET ModDate: Mon Dec 15 14:34:04 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 355733 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NOGAOP+GuardianSans-Medium Type 1C Custom yes yes yes 19 0 NOGAPA+GuardianSans-MediumIt Type 1C Custom yes yes yes 20 0 NOGAPC+GuardianSansGR-Regular Type 1C Custom yes yes yes 21 0 NOGAPE+GuardianSans-Semibold Type 1C Custom yes yes yes 22 0 NOGAPG+GuardianSans-RegularIt Type 1C Custom yes yes yes 23 0 LYEMIK+ArialMT TrueType WinAnsi yes yes no 1 0 NOGBBD+GuardianTextEgypGR-Regular Type 1C Custom yes yes yes 57 0 NOGBBG+GuardianTextEgyp-RegularIt Type 1C Custom yes yes yes 58 0 NOGBCE+GuardianTextEgypGR-Medium Type 1C Custom yes yes yes 73 0 NOGBDK+GuardianAgateSans1GR-Bold Type 1C WinAnsi yes yes no 74 0 NOGBDM+GuardianAgateSans1GR-Regular Type 1C Custom yes yes yes 75 0 NOGBDO+GuardianAgateSans1D-RegularIt Type 1C Custom yes yes yes 76 0 NOGBFA+GuardianAgateSansGR-Medium Type 1C Custom yes yes yes 103 0 NOGBHI+GuardianAgateSans1D-Bold Type 1C WinAnsi yes yes no 112 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-12-16 04:13:54 CET RepresentationInformation: 322334.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-12-15 14:55:24 CET Size: 355733 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 165 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: Author: American Medical Association Subject: Keywords: The JAMA Network Creator: XPP Producer: ; modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Tue Nov 05 14:47:38 CET 2024 ModDate: Mon Dec 15 14:34:04 CET 2025 ID: 0x975fecda175a94a0f29d7fc495c20956, 0xbe80fb9054b91989e4848fe8137fe08d Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NOGBFA+GuardianAgateSansGR-Medium FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: NOGBFA+GuardianAgateSansGR-Medium Flags: Symbolic FontBBox: -260, -204, 1070, 1036 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBCE+GuardianTextEgypGR-Medium FontSubset: true FirstChar: 2 LastChar: 117 FontDescriptor: FontName: NOGBCE+GuardianTextEgypGR-Medium Flags: Serif, Symbolic FontBBox: -197, -282, 1310, 1192 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBDK+GuardianAgateSans1GR-Bold FontSubset: true FirstChar: 49 LastChar: 57 FontDescriptor: FontName: NOGBDK+GuardianAgateSans1GR-Bold Flags: Nonsymbolic FontBBox: -273, -224, 1073, 1027 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOGBDM+GuardianAgateSans1GR-Regular FontSubset: true FirstChar: 2 LastChar: 133 FontDescriptor: FontName: NOGBDM+GuardianAgateSans1GR-Regular Flags: Symbolic FontBBox: -250, -204, 1063, 1036 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBDO+GuardianAgateSans1D-RegularIt FontSubset: true FirstChar: 51 LastChar: 83 FontDescriptor: FontName: NOGBDO+GuardianAgateSans1D-RegularIt Flags: Symbolic, Italic FontBBox: -270, -204, 1043, 1036 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBHI+GuardianAgateSans1D-Bold FontSubset: true FirstChar: 65 LastChar: 66 FontDescriptor: FontName: NOGBHI+GuardianAgateSans1D-Bold Flags: Nonsymbolic, ForceBold FontBBox: -271, -226, 1072, 1036 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NOGAOP+GuardianSans-Medium FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: NOGAOP+GuardianSans-Medium Flags: Symbolic FontBBox: -180, -219, 1240, 1072 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGAPA+GuardianSans-MediumIt FontSubset: true FirstChar: 51 LastChar: 83 FontDescriptor: FontName: NOGAPA+GuardianSans-MediumIt Flags: Symbolic, Italic FontBBox: -224, -219, 1166, 1072 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGAPC+GuardianSansGR-Regular FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: NOGAPC+GuardianSansGR-Regular Flags: Symbolic FontBBox: -175, -217, 1194, 1061 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGAPE+GuardianSans-Semibold FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: NOGAPE+GuardianSans-Semibold Flags: Symbolic FontBBox: -185, -222, 1277, 1082 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGAPG+GuardianSans-RegularIt FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: NOGAPG+GuardianSans-RegularIt Flags: Symbolic, Italic FontBBox: -217, -217, 1106, 1061 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBBD+GuardianTextEgypGR-Regular FontSubset: true FirstChar: 2 LastChar: 133 FontDescriptor: FontName: NOGBBD+GuardianTextEgypGR-Regular Flags: Serif, Symbolic FontBBox: -194, -276, 1315, 1195 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NOGBBG+GuardianTextEgyp-RegularIt FontSubset: true FirstChar: 2 LastChar: 83 FontDescriptor: FontName: NOGBBG+GuardianTextEgyp-RegularIt Flags: Serif, Symbolic, Italic FontBBox: -204, -276, 1296, 1195 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true TrueType: Font: BaseFont: LYEMIK+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: LYEMIK+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: American Medical Association 2024-11-05T13:47:38Z XPP 2024-11-05T13:47:38Z The JAMA Network Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 250, 192, 304, 204 Annotation: Subtype: Link Rect: 198, 74, 289, 83 Annotation: Subtype: Link Rect: 443, 599, 515, 609 Annotation: Subtype: Link Rect: 432, 65, 497, 74 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 177, 328, 230, 339 Annotation: Subtype: Link Rect: 120, 294, 149, 305 Annotation: Subtype: Link Rect: 204, 237, 260, 247 Annotation: Subtype: Link Rect: 169, 202, 225, 213 Annotation: Subtype: Link Rect: 166, 179, 221, 190 Annotation: Subtype: Link Rect: 484, 41, 540, 50 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 269, 512, 300, 523 Annotation: Subtype: Link Rect: 71, 501, 100, 511 Annotation: Subtype: Link Rect: 113, 260, 165, 270 Annotation: Subtype: Link Rect: 192, 237, 246, 247 Annotation: Subtype: Link Rect: 119, 122, 173, 132 Annotation: Subtype: Link Rect: 71, 64, 125, 75 Annotation: Subtype: Link Rect: 478, 282, 534, 293 Annotation: Subtype: Link Rect: 509, 248, 540, 259 Annotation: Subtype: Link Rect: 310, 237, 341, 247 Annotation: Subtype: Link Rect: 71, 41, 126, 50 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 484, 41, 540, 50 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 71, 41, 126, 50 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 82, 671, 173, 680 Annotation: Subtype: Link Rect: 169, 650, 211, 659 Annotation: Subtype: Link Rect: 71, 641, 94, 650 Annotation: Subtype: Link Rect: 317, 279, 359, 288 Annotation: Subtype: Link Rect: 292, 113, 369, 122 Annotation: Subtype: Link Rect: 474, 704, 536, 713 Annotation: Subtype: Link Rect: 390, 695, 427, 704 Annotation: Subtype: Link Rect: 401, 650, 495, 659 Annotation: Subtype: Link Rect: 442, 604, 537, 614 Annotation: Subtype: Link Rect: 435, 559, 529, 568 Annotation: Subtype: Link Rect: 504, 514, 531, 523 Annotation: Subtype: Link Rect: 390, 505, 418, 514 Annotation: Subtype: Link Rect: 462, 468, 540, 477 Annotation: Subtype: Link Rect: 489, 440, 513, 449 Annotation: Subtype: Link Rect: 390, 431, 450, 441 Annotation: Subtype: Link Rect: 436, 369, 533, 378 Annotation: Subtype: Link Rect: 478, 323, 535, 333 Annotation: Subtype: Link Rect: 390, 315, 423, 324 Annotation: Subtype: Link Rect: 450, 253, 540, 262 Annotation: Subtype: Link Rect: 390, 244, 408, 253 Annotation: Subtype: Link Rect: 428, 199, 511, 208 Annotation: Subtype: Link Rect: 466, 162, 539, 171 Annotation: Subtype: Link Rect: 401, 116, 473, 126 Annotation: Subtype: Link Rect: 401, 71, 458, 80 Annotation: Subtype: Link Rect: 484, 41, 540, 50 Checksum: 3c978675 Type: CRC32 Checksum: b4defb1e336390c6f5bb8a210dcbd844 Type: MD5 Checksum: d07057c2d892a08efb734572133d456ac3860e69 Type: SHA-1 Checksum: 9d2e7f0f12d773f87745792a360d531757bad08612627246317b87d5ef1ae68d Type: SHA-256