9bce9ab0a36468f7e8675c12179bc8a1 324415.pdf 2dea0c7c19e0e7ad9a986ec3e03858220767c62d 324415.pdf b710f672d39dfb729de5c04f6cf92ed07d8e71655a6331ec4c4fcaad1e370509 324415.pdf Title: Ibero-American Consensus for the Management of Peritoneal Sarcomatosis: Updated Review and Clinical Recommendations Subject: Peritoneal sarcomatosis is a rare malignant disease with a poor prognosis, secondary to peritoneal dissemination of abdominopelvic soft tissue sarcomas. Its rarity, together with the characteristic histological heterogeneity and the historically poor response to systemic treatments, has prevented the establishment of widely accepted treatment criteria with curative intent. In this sense, radical cytoreductive surgery (CRS) with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy (HIPEC), widely used in peritoneal carcinomatosis with excellent results, have not had the same evolutionary development in patients with peritoneal sarcomatosis. A multidisciplinary working group of experts in sarcomas and peritoneal oncological surgery established a series of recommendations based on current scientific evidence for the management of peritoneal sarcomatosis, taking into account the different histological subgroups of abdominopelvic sarcomas that can cause it depending on their origin: retroperitoneal sarcomas, uterine sarcomas, and visceral/peritoneal sarcomas of GIST (gastrointestinal stromal tumor) and non-GIST origin. This article shows the results of sarcoma experts’ voting on the recommendations presented during the I Ibero-American Consensus on the Management of Peritoneal Sarcomatosis, which took place during the recent celebration of the III Hispanic-Portuguese Meeting for Updates on the Treatment of Sarcomas. Keywords: peritoneal sarcomatosis; soft tissue sarcoma; peritoneal GIST; peritonectomy procedures; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; induction chemotherapy; targeted therapy Author: Francisco Cristóbal Muñoz-Casares, Javier Martín-Broto, Pedro Cascales-Campos, Juan Torres-Melero, Irene López-Rojo, José Gómez-Barbadillo, Luis González-Bayón, Ana Sebio, César Serrano, Sara Carvalhal, Joaquim Abreu de Souza, Alexandre Souza, Guillermo Flores-Ayala, Luis José Palacios Fuenmayor, Raquel Lopes-Bras, José Antonio González-López, Hugo Vasques and José Manuel Asencio-Pascual Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Jul 25 11:20:22 2024 CEST ModDate: Thu Jul 25 11:31:44 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 28 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 407546 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 SZKUGL+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 JBWEUO+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 LMVSNH+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 EUNBMT+VnURWPalladioL Type 1 Custom yes yes yes 32 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 SVJPRA+CMSY10 Type 1 Builtin yes yes yes 87 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-01-27 04:17:45 CET RepresentationInformation: 324415.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-01-26 13:39:29 CET Size: 407546 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 586 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methodology Destination: section.2 Children: Item: Title: Working Group Destination: subsection.2.1 Item: Title: Bibliographic Search Destination: subsection.2.2 Item: Title: Consensus Meeting Destination: subsection.2.3 Item: Title: Scientific Evidence of CRS-HIPEC Procedures in Peritoneal Sarcomatosis Destination: section.3 Children: Item: Title: Uterine Peritoneal Sarcomatosis: Evidence for CRS-HIPEC and Systemic Treatment Destination: subsection.3.1 Item: Title: Peritoneal Sarcomatosis of Retroperitoneal Origin: Evidence from CRS-HIPEC and Systemic Treatment Destination: subsection.3.2 Item: Title: Peritoneal Sarcomatosis Of Origin In GIST Visceral/Peritoneal Sarcomas: Evidence In CRS-HIPEC And Systemic Treatment Destination: subsection.3.3 Item: Title: Peritoneal Sarcomatosis Of Origin In Non-GIST Visceral/Peritoneal Sarcomas: Evidence in CRS-HIPEC and Systemic Treatment Destination: subsection.3.4 Children: Item: Title: Desmoplastic Small Round Cell Tumor (DSRCT) Destination: subsubsection.3.4.1 Item: Title: Rhabdomyosarcoma (RMS) Destination: subsubsection.3.4.2 Item: Title: Epithelial Inflammatory Myofibroblastic Sarcoma (EIMS) Destination: subsubsection.3.4.3 Item: Title: Less Common STS-derived Peritoneal Sarcomatosis Destination: subsubsection.3.4.4 Item: Title: Clinical Recommendations and Consensus for the Management of Peritoneal Sarcomatosis Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Ibero-American Consensus for the Management of Peritoneal Sarcomatosis: Updated Review and Clinical Recommendations Author: Francisco Cristóbal Muñoz-Casares, Javier Martín-Broto, Pedro Cascales-Campos, Juan Torres-Melero, Irene López-Rojo, José Gómez-Barbadillo, Luis González-Bayón, Ana Sebio, César Serrano, Sara Carvalhal, Joaquim Abreu de Souza, Alexandre Souza, Guillermo Flores-Ayala, Luis José Palacios Fuenmayor, Raquel Lopes-Bras, José Antonio González-López, Hugo Vasques and José Manuel Asencio-Pascual Subject: Peritoneal sarcomatosis is a rare malignant disease with a poor prognosis, secondary to peritoneal dissemination of abdominopelvic soft tissue sarcomas. Its rarity, together with the characteristic histological heterogeneity and the historically poor response to systemic treatments, has prevented the establishment of widely accepted treatment criteria with curative intent. In this sense, radical cytoreductive surgery (CRS) with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy (HIPEC), widely used in peritoneal carcinomatosis with excellent results, have not had the same evolutionary development in patients with peritoneal sarcomatosis. A multidisciplinary working group of experts in sarcomas and peritoneal oncological surgery established a series of recommendations based on current scientific evidence for the management of peritoneal sarcomatosis, taking into account the different histological subgroups of abdominopelvic sarcomas that can cause it depending on their origin: retroperitoneal sarcomas, uterine sarcomas, and visceral/peritoneal sarcomas of GIST (gastrointestinal stromal tumor) and non-GIST origin. This article shows the results of sarcoma experts’ voting on the recommendations presented during the I Ibero-American Consensus on the Management of Peritoneal Sarcomatosis, which took place during the recent celebration of the III Hispanic-Portuguese Meeting for Updates on the Treatment of Sarcomas. 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