56a3c97e7267fd1e970f5f5e1cee2e85 IFON_20_12367166.pdf 3e5c06e610477b94acb1853e6d701175edddd620 IFON_20_12367166.pdf a278500293576406550f014822d5c754bf5579ba10976c2d33b2a37a9af18df6 IFON_20_12367166.pdf Title: SEAMARK: phase II study of first-line encorafenib and cetuximab plus pembrolizumab for MSI-H/dMMR BRAF V600E-mutant mCRC Subject: 10.2217/fon-2022-1249 Keywords: BRAF V600, cetuximab, dMMR, encorafenib, immunotherapy, metastatic colorectal cancer, MSI-H, pembrolizumab, targeted therapy, triplet combination therapy Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 9.0.0 (Windows) CreationDate: Thu Mar 21 09:25:28 2024 CET ModDate: Thu Mar 21 10:17:41 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 589.92 x 793.6 pts Page rot: 0 File size: 3928977 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KEFKPN+FrutigerLTStd-Roman Type 1C Custom yes yes yes 19 0 KEFNDJ+MyriadPro-Semibold Type 1C Custom yes yes yes 28 0 KEFNDK+MTSY Type 1C Custom yes yes yes 29 0 KEFMPC+FrutigerLTStd-LightItalic Type 1C Custom yes yes yes 20 0 KEFMPD+RMTMI Type 1C Custom yes yes yes 21 0 KEFMPE+FrutigerLTStd-Italic Type 1C Custom yes yes yes 22 0 KEFMPF+FrutigerLTStd-Light Type 1C Custom yes yes yes 23 0 KEFMPG+RMTMUB Type 1C Custom yes yes yes 24 0 KEFNAH+FrutigerLTStd-Bold Type 1C Custom yes yes yes 25 0 KEFNCH+MyriadPro-SemiboldIt Type 1C Custom yes yes yes 26 0 KEFNDI+MyriadPro-Light Type 1C Custom yes yes yes 27 0 KEFNEK+AGaramond-Regular Type 1C MacRoman yes yes no 48 0 KEFNEL+AGaramond-Italic Type 1C WinAnsi yes yes no 49 0 KEGBAF+HelveticaLTStd-Roman Type 1C Custom yes yes yes 65 0 KEGBAG+HelveticaLTStd-Bold Type 1C Custom yes yes yes 66 0 KEGCFP+SFRM0800 Type 1C Custom yes yes yes 147 0 KEGDFK+AGaramond-Bold Type 1C MacRoman yes yes no 196 0 KEGEAH+AGaramond-BoldItalic Type 1C WinAnsi yes yes no 228 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-05 04:21:01 CET RepresentationInformation: IFON_20_12367166.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-04 14:42:21 CET Size: 3928977 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 8 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1023 ImageHeight: 864 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 424 ImageHeight: 1809 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 635 ImageHeight: 404 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 846 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 847 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 846 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1902 ImageHeight: 404 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 846 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 424 ImageHeight: 203 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 847 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 846 ImageHeight: 805 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: KEGBAF+HelveticaLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 128 FontDescriptor: FontName: KEGBAF+HelveticaLTStd-Roman Flags: Symbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEGBAG+HelveticaLTStd-Bold FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: KEGBAG+HelveticaLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEGDFK+AGaramond-Bold FontSubset: true FirstChar: 40 LastChar: 222 FontDescriptor: FontName: KEGDFK+AGaramond-Bold Flags: Serif, Nonsymbolic, ForceBold FontBBox: -158, -269, 1147, 862 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEGEAH+AGaramond-BoldItalic FontSubset: true FirstChar: 65 LastChar: 82 FontDescriptor: FontName: KEGEAH+AGaramond-BoldItalic Flags: Serif, Nonsymbolic, Italic, ForceBold FontBBox: -183, -285, 1166, 862 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEFNEK+AGaramond-Regular FontSubset: true FirstChar: 35 LastChar: 223 FontDescriptor: FontName: KEFNEK+AGaramond-Regular Flags: Serif, Nonsymbolic FontBBox: -183, -269, 1099, 851 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEFNEL+AGaramond-Italic FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: KEFNEL+AGaramond-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -182, -285, 1150, 851 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEFKPN+FrutigerLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 144 FontDescriptor: FontName: KEFKPN+FrutigerLTStd-Roman Flags: Symbolic FontBBox: -169, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEGCFP+SFRM0800 FontSubset: true FirstChar: 128 LastChar: 128 FontDescriptor: FontName: KEGCFP+SFRM0800 Flags: Serif, Symbolic FontBBox: -203, -320, 1554, 938 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFMPC+FrutigerLTStd-LightItalic FontSubset: true FirstChar: 44 LastChar: 117 FontDescriptor: FontName: KEFMPC+FrutigerLTStd-LightItalic Flags: Symbolic, Italic FontBBox: -143, -250, 1031, 917 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFMPD+RMTMI FontSubset: true FirstChar: 47 LastChar: 62 FontDescriptor: FontName: KEFMPD+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFMPE+FrutigerLTStd-Italic FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: KEFMPE+FrutigerLTStd-Italic Flags: Symbolic, Italic FontBBox: -169, -250, 1091, 930 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFMPF+FrutigerLTStd-Light FontSubset: true FirstChar: 2 LastChar: 180 FontDescriptor: FontName: KEFMPF+FrutigerLTStd-Light Flags: Symbolic FontBBox: -152, -250, 1000, 911 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFMPG+RMTMUB FontSubset: true FirstChar: 47 LastChar: 47 FontDescriptor: FontName: KEFMPG+RMTMUB Flags: Symbolic, ForceBold FontBBox: 0, -208, 994, 699 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFNAH+FrutigerLTStd-Bold FontSubset: true FirstChar: 2 LastChar: 133 FontDescriptor: FontName: KEFNAH+FrutigerLTStd-Bold Flags: Symbolic, ForceBold FontBBox: -166, -250, 1000, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFNCH+MyriadPro-SemiboldIt FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: KEFNCH+MyriadPro-SemiboldIt Flags: Symbolic, Italic, ForceBold FontBBox: -103, -250, 1165, 882 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFNDI+MyriadPro-Light FontSubset: true FirstChar: 40 LastChar: 133 FontDescriptor: FontName: KEFNDI+MyriadPro-Light Flags: Symbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFNDJ+MyriadPro-Semibold FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: KEFNDJ+MyriadPro-Semibold Flags: Symbolic, ForceBold FontBBox: -71, -250, 1198, 889 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEFNDK+MTSY FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: KEFNDK+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Issue 10.2217/fon-2022-1249 VoR BRAF V600, cetuximab, dMMR, encorafenib, immunotherapy, metastatic colorectal cancer, MSI-H, pembrolizumab, targeted therapy, triplet combination therapy Acrobat Distiller 9.0.0 (Windows) 2024-03-21T09:17:41Z 2024-03-21T04:25:28-04:00 LaTeX with hyperref package 2024-03-21T09:17:41Z application/pdf SEAMARK: phase II study of first-line encorafenib and cetuximab plus pembrolizumab for MSI-H/dMMR BRAF V600E-mutant mCRC 10.2217/fon-2022-1249 © 2023 Pfizer Inc. True https://www.future-science.com/terms uuid:95f23f91-ac42-4ce8-87f7-ba430c080184 uuid:66c5e0e1-6373-4c37-a2d5-1c6ef40047e3 Pages: Page: Label: 653 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 168, 61, 227, 72 Annotation: Subtype: Link Rect: 230, 61, 302, 72 Annotation: Subtype: Link Rect: 308, 61, 376, 72 Page: Label: 654 Sequence: 2 Page: Label: 655 Sequence: 3 Page: Label: 656 Sequence: 4 Page: Label: 657 Sequence: 5 Page: Label: 658 Sequence: 6 Page: Label: 659 Sequence: 7 Page: Label: 660 Sequence: 8 Page: Label: 661 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 74, 544, 278, 554 Annotation: Subtype: Link Rect: 64, 495, 238, 505 Annotation: Subtype: Link Rect: 65, 374, 485, 397 Annotation: Subtype: Link Rect: 115, 190, 191, 201 Annotation: Subtype: Link Rect: 374, 176, 439, 187 Page: Label: 662 Sequence: 10 Page: Label: 663 Sequence: 11 Checksum: c57a9377 Type: CRC32 Checksum: 56a3c97e7267fd1e970f5f5e1cee2e85 Type: MD5 Checksum: 3e5c06e610477b94acb1853e6d701175edddd620 Type: SHA-1 Checksum: a278500293576406550f014822d5c754bf5579ba10976c2d33b2a37a9af18df6 Type: SHA-256